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Entry version 38 (07 Oct 2020)
Sequence version 2 (05 Jun 2019)
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Protein

ALMS_motif domain-containing protein

Gene
N/A
Organism
Anas platyrhynchos platyrhynchos (Northern mallard)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ALMS_motif domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnas platyrhynchos platyrhynchos (Northern mallard)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8840 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnatinaeAnas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000016666 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1618 – 1755ALMS_motifInterPro annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni356 – 391DisorderedSequence analysisAdd BLAST36
Regioni532 – 576DisorderedSequence analysisAdd BLAST45
Regioni644 – 700DisorderedSequence analysisAdd BLAST57
Regioni828 – 853DisorderedSequence analysisAdd BLAST26
Regioni1088 – 1111DisorderedSequence analysisAdd BLAST24
Regioni1130 – 1159DisorderedSequence analysisAdd BLAST30
Regioni1320 – 1339DisorderedSequence analysisAdd BLAST20
Regioni1539 – 1562DisorderedSequence analysisAdd BLAST24
Regioni1583 – 1604DisorderedSequence analysisAdd BLAST22
Regioni1636 – 1672DisorderedSequence analysisAdd BLAST37
Regioni1692 – 1760DisorderedSequence analysisAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili49 – 69Sequence analysisAdd BLAST21
Coiled coili97 – 138Sequence analysisAdd BLAST42
Coiled coili218 – 245Sequence analysisAdd BLAST28
Coiled coili256 – 276Sequence analysisAdd BLAST21
Coiled coili581 – 619Sequence analysisAdd BLAST39
Coiled coili890 – 917Sequence analysisAdd BLAST28
Coiled coili919 – 955Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi372 – 389PolyampholyteSequence analysisAdd BLAST18
Compositional biasi543 – 569PolarSequence analysisAdd BLAST27
Compositional biasi668 – 688PolarSequence analysisAdd BLAST21
Compositional biasi828 – 850PolarSequence analysisAdd BLAST23
Compositional biasi1094 – 1111PolarSequence analysisAdd BLAST18
Compositional biasi1320 – 1335PolarSequence analysisAdd BLAST16
Compositional biasi1587 – 1604PolarSequence analysisAdd BLAST18
Compositional biasi1636 – 1671PolyampholyteSequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_423666_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029299, ALMS_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15309, ALMS_motif, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

U3J570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRKVAKVGK LRLSPNEETM LLKEEYERRR KLRLQQVREQ QKYIALQIRQ
60 70 80 90 100
KVKQKREEQL HQLEETLRAE WQKEQDEKIK ALEKLFLSSL RAVGEGHRQA
110 120 130 140 150
KENEPDLEAL AKQAEERKQR AEKRHRKALR EQKFQKEKLL HEQTRRINAR
160 170 180 190 200
KHALDVERER AAKVASLPPP PPHPLENFEA KKIPAVKAYG AGNFSITRYH
210 220 230 240 250
ISEPYVDREM DGEQPDARLA AEEEVKRLEE LHREAEREKR EQVAKAHLRG
260 270 280 290 300
SHALKKVHLA QDRERLLKEL EQMQNVDRMR RRQRVAQMPP QLFVPAYKRM
310 320 330 340 350
EIKDDWQREL EFAFEDMYSE DRQMKGDLIL QFEPQPLPTP SDRSQDNDLD
360 370 380 390 400
LSLEQESACD NQQESEQMTE GEVPDESEKH EEAKTHQSQS KLALKKLLNK
410 420 430 440 450
IRSQKEEWTS KNEKEIPSEA ETIESGTIPS EERQLCDVEL DCEQHKNSVC
460 470 480 490 500
EAEDSVETLE HTAAAESSIL IHPQEQAAKI RMENERKKLI EQIEQQKQEQ
510 520 530 540 550
LALLKQIEEK KARLEADLLK IQMQTCLEEA KNKEEEEEKG QPVQSCSIPS
560 570 580 590 600
PDQPKEVEQE SGSTAVSETR SPREDSHLQM IRNYQQRLLQ QNRLHEQTIE
610 620 630 640 650
EARKRLQEYQ NKLKERYSAA SVTPSSSVET KSVLKPVLEP VLQRQRVQRT
660 670 680 690 700
QHQSPEQVRA EDHARSPPVF SSLSNVPEST SSQNHEEQTH HVCPGRHAQP
710 720 730 740 750
LETSKSRYGE FHLPWSCPSQ EPVSLLETSP DQAREPSPFQ LPSASVTQGV
760 770 780 790 800
TAVRTRTEAR VQHVRFALPA EDSSEPSEAE HFQESSQVMS DCQTETEAVE
810 820 830 840 850
EPPLTAAFTP ATGSHVVQAA TAEFLAGQQG SVGSTTRTSL EPTARTEPVT
860 870 880 890 900
SSHEEGVEEF LTSKSGQASL LNYSGILNLR DRMLASSESI QAQQRYLKEL
910 920 930 940 950
QEQLDAQREA LLSRQKIQEQ LLLQKHSKLK EQMQMQEQEA LKEFLNKQVR
960 970 980 990 1000
RISTNEEMTE ALMPDWINRS DIFQDSENYQ QENCGMNKLH RNEMISQCID
1010 1020 1030 1040 1050
LAGQTEQPEK VLHREQKWRS SKPPVTKVKL GLDLEQHELS VIPEVDTPRS
1060 1070 1080 1090 1100
CNVSFAGKTD SVGGESSTMS TVGEFAYVKC YSPALRKDGR SPGSITSCEE
1110 1120 1130 1140 1150
QISGESPRQR KQSGLLQELL LMSAETSCDS AQSQDSLTAR DSPFPAAEVG
1160 1170 1180 1190 1200
EETPRSGPSF RSIHAEVLSK VVSPDLCSEA FMQAIPCDLS STISTGSFLT
1210 1220 1230 1240 1250
SETLDASPID TGLSSDSTED RILKKTGSCP WSSLLPFTSR LRQENLSRAP
1260 1270 1280 1290 1300
ETWLPEGATF LYKGSETQQI LEKCGGDLNS SSENNVHFQG SDESFHPLRA
1310 1320 1330 1340 1350
ESSLSDLSQN ADQPEDRNIM LETSSGQNPG IRVRDNENGI SSAREYEELT
1360 1370 1380 1390 1400
RSMECVSLQC SMEETRNESL SSLEEQKSFY QLNTTPVPVD KTSPQHLLNE
1410 1420 1430 1440 1450
SVTFRQEALS SEEKLPVKVF DRKYVKLPEK FLHVHEANKA VAVDSQCNSH
1460 1470 1480 1490 1500
VKEPDQGFPE VQKSSWITRE TSLEVPGIHL QAVQQNVSFL GRREKHSSSV
1510 1520 1530 1540 1550
PGSSCRIPVW ETESGHGIME EPELTLISSN DISVVESDVE HMNQEKSEED
1560 1570 1580 1590 1600
KISNPASADK SDLNDFTEER EFLPLVPDAD YSMFVRPDSS SRAQSPNDRQ
1610 1620 1630 1640 1650
HPSHQTAVMR LEFPSASGSL QESFLKRKKS FIQKSLERVE EIKNRERKNE
1660 1670 1680 1690 1700
KPEAKPFQRR KSEKLSRQKE SFLLPGKKGA VVNQLKKVGE VKVSSPEDRK
1710 1720 1730 1740 1750
AGKVEMHQRT SRLYNQLEEV KTRKEEKKRQ ETSAKNREKA KEFQKKMLEK
1760
LRAKKTGKTP
Length:1,760
Mass (Da):200,665
Last modified:June 5, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE74DDAF65331BEC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A493TUD1A0A493TUD1_ANAPP
ALMS_motif domain-containing protei...
1,916Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A493SW31A0A493SW31_ANAPP
ALMS_motif domain-containing protei...
1,937Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAPLT00000015429; ENSAPLP00000014647; ENSAPLG00000014794

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSAPLT00000015429; ENSAPLP00000014647; ENSAPLG00000014794

Phylogenomic databases

GeneTreeiENSGT00940000153123
HOGENOMiCLU_423666_0_0_1

Family and domain databases

InterProiView protein in InterPro
IPR029299, ALMS_motif
PfamiView protein in Pfam
PF15309, ALMS_motif, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU3J570_ANAPP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: U3J570
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: June 5, 2019
Last modified: October 7, 2020
This is version 38 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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