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Protein
Submitted name:

Disintegrin and metalloproteinase domain-containing protein 19 preproprotein

Gene

ADAM19

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinImported

Protein family/group databases

MEROPSiM12.214

Names & Taxonomyi

Protein namesi
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 19 preproproteinImported
Gene namesi
Name:ADAM19Imported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei703 – 724HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501015280926 – 918Sequence analysisAdd BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi474 ↔ 494PROSITE-ProRule annotation
Disulfide bondi654 ↔ 664PROSITE-ProRule annotation
Disulfide bondi672 ↔ 681PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 408Peptidase M12BInterPro annotationAdd BLAST199
Domaini416 – 502DisintegrinInterPro annotationAdd BLAST87
Domaini650 – 682EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
KOiK08608

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033596 ADAM19
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF19 PTHR11905:SF19, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

U3FXS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGAGAARL CLLALALQLL RPRAAQEPGW TRGSGAGSPQ LQHELIIPQW
60 70 80 90 100
KTSESPVREQ HPLKAELRVM AEGRELILDL EKNEQLFAPS YTETHYTSRG
110 120 130 140 150
NPQTTTLKSE DHCFYHGTVR ETELSSVTLS TCRGIRGLIT VSSNLSYVIE
160 170 180 190 200
PLPDSEGQHL IYRSEHLKLP LGSCGIEHFK PTTRDWALQF TQQTKKRPRR
210 220 230 240 250
MKREDLNSMK YVELYLVADY AEFQKNRRDQ DATKHKLIEI ANYVDKFYRS
260 270 280 290 300
LNIRIALVGL EVWTHGNMCE VSENPYSTLW SFLSWRRKLL SQKNHDNAQL
310 320 330 340 350
ITGMSFHGTT IGLAPLMAMC SVYQSGGVNM DHSENAIGVA ATMAHEMGHN
360 370 380 390 400
FGMSHDSADC CSASAADGGC IMAAATGHPF PRVFNGCNRR ELDRYLQSGG
410 420 430 440 450
GMCLSNMPDT RTLYGGRRCG NGYLEDGEEC DCGEEEECNN PCCNASNCTL
460 470 480 490 500
KQGAECAHGS CCHECKLLAP GTLCREQARQ CDLPEFCTGK SPHCPTNFYQ
510 520 530 540 550
MDGTPCEGGQ AYCYNGMCLT YQEQCQQLWG PGARPAPDLC FEKVNVAGDT
560 570 580 590 600
FGNCGKDMNG EHRKCNMRDA KCGKIQCQSS EARPLESNAV PIDTTIIMNG
610 620 630 640 650
RQIQCRGTHV YRGPEEESDM LDPGLVMTGT KCGYNHICFE GQCRNTSFFE
660 670 680 690 700
TEGCGKKCNG HGVCNNNQNC HCLPGWAPPF CNTPGQGGSI DSGPMPPESV
710 720 730 740 750
GPVVAGVLAA IFVLVVLLLI YYCCRQNKKL GQLKPSALPS KLRQQFSCPF
760 770 780 790 800
RVSQNSGTGH ANPTFKLQTP QGKRKVINTP EILRKPSQPP PRPPPDYLRG
810 820 830 840 850
GSPPALLPAH LSRAARNSPA PASQIERTES SRRPPPSRPV PPAPHCILSQ
860 870 880 890 900
DFSRPRPPQK ALPANPVPGR RALPRPGGAS TLWPPGASPR QSQPVAAPAP
910
KFPEYRSQRA GGVISSKI
Length:918
Mass (Da):100,702
Last modified:November 13, 2013 - v1
Checksum:i52514508EF6F91BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01004454 mRNA Translation: JAB07407.1
GAMP01001555 mRNA Translation: JAB51200.1
RefSeqiXP_002744143.3, XM_002744097.4

Genome annotation databases

GeneIDi100389375
KEGGicjc:100389375

Similar proteinsi

Entry informationi

Entry nameiU3FXS6_CALJA
AccessioniPrimary (citable) accession number: U3FXS6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: July 18, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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