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Entry version 19 (31 Jul 2019)
Sequence version 1 (13 Nov 2013)
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Protein

Reticulon

Gene

RTN4

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ReticulonUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTN4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1027 – 1050HelicalUniRule annotationAdd BLAST24
Transmembranei1136 – 1157HelicalUniRule annotationAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1007 – 1194ReticulonInterPro annotationAdd BLAST188

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 197DisorderedSequence analysisAdd BLAST197
Regioni432 – 455DisorderedSequence analysisAdd BLAST24
Regioni509 – 536DisorderedSequence analysisAdd BLAST28
Regioni626 – 669DisorderedSequence analysisAdd BLAST44
Regioni724 – 761DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19PolarSequence analysisAdd BLAST19
Compositional biasi31 – 52AcidicSequence analysisAdd BLAST22
Compositional biasi107 – 128PolarSequence analysisAdd BLAST22
Compositional biasi140 – 173Pro-richSequence analysisAdd BLAST34
Compositional biasi628 – 646PolarSequence analysisAdd BLAST19

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1792 Eukaryota
ENOG410XPKH LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003388 Reticulon

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02453 Reticulon, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50845 RETICULON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

U3F9N8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEEEEEEEEE EEEDEDEDLE
60 70 80 90 100
ELEVLERKPA AGLSAAPVPT APAASAPLMD FGNDFVPPAP RGPLPAASPA
110 120 130 140 150
TPERQPSWDP SPVSSTVPAP SLPSATAVSP SKLPEDDEPP ARPPPPPPAS
160 170 180 190 200
VSPPAEPAWT PPAPAPAAPP STPAAPKRRG SSGSVDETLF ALPASSEPVI
210 220 230 240 250
RSSAEKIMDL KEQPGNSISA GQEDFPSVLL ETAASLPSLS PLSAASFKEH
260 270 280 290 300
EYLGNLSAVL PSKGTLQETV NEASKEFSEK AKTLLIERDL TEFSELEYSE
310 320 330 340 350
MGSSFSGSPK AESAVIVANP KEEIIVKNKD EEENLVSNNI PHNQQELPVA
360 370 380 390 400
HTKLVKEEDI VTSSEKVKDS FNEKTVAAEA PMSEEYADFK PFERVWEVKD
410 420 430 440 450
SKGVSDMLAA GGKIDSTLES KVDKKCFADS LEQTNHEKDG ESSNDDTSFP
460 470 480 490 500
STPEAIKDRS GAYITCAPFN PVATESIAAN IFPLLGDHTS ENKTDEKKIE
510 520 530 540 550
ERKAQIVTEK TTSAKTSNPF LVAAQGSETD YVTTDNSAKV TEEVGANMPE
560 570 580 590 600
GLTPDLVQEA YESELNEVTG TKIAYETKMD LVQTSEAVQD SLCPVAQLCP
610 620 630 640 650
SFEESEATPS PVLPDIVMEA PLNSAVPSAG ASAVQPSSSP LEASSVNFES
660 670 680 690 700
VKHEPENPPP YEEAMNVSRK KVSGIKEEIK EPESINAAVQ ETEAPYISIA
710 720 730 740 750
CDLIKETKLS AEPTPDFSSY SEMAKVEQPL PDHSELVEDS SPDSEPVDLF
760 770 780 790 800
SDDSIPDVPQ KQDEAVILVK ETLTETSFES MIEHENKEKL SALSPEGGKL
810 820 830 840 850
YLESFKLHLD TTKDMLLPDE VSTLNKREKI PLQMEELSTA VSSNDDLFIS
860 870 880 890 900
KEAQMRETET FSDSSPIEII DEFPTLISSK TDSLSKLARE YTDLEVSHKS
910 920 930 940 950
EIANAQDEAG SLPCAELPHD LSFKNVQPKV EAKINFSDDF SKNGSAMSKV
960 970 980 990 1000
LLLPSDVSAL ATQAEIGSIA KPKVLVKEAE KKLPSDTERE DKSPSAIFSA
1010 1020 1030 1040 1050
ELSKTSVVDL LYWRDIKKTG VVFGASLFLL LSLTVFSIVS VTAYIALALL
1060 1070 1080 1090 1100
SVTISFRIYK GVIQAIQKSD EGHPFRAYLE SEVAISEELV QKYSNSALGH
1110 1120 1130 1140 1150
VNCTIKELRR LFLVDDLVDS LKFAVLMWVF TYVGALFNGL TLLILALISL
1160 1170 1180 1190
FSVPVIYERH QAQIDHYLGL ANKNVKDAMA KIQAKIPGLK RKAE
Length:1,194
Mass (Da):129,632
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A12FF99A9FDB724
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GAMP01000331 mRNA Translation: JAB52424.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMP01000331 mRNA Translation: JAB52424.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU3F9N8_CALJA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: U3F9N8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: July 31, 2019
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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