UniProtKB - U3EYN1 (U3EYN1_CALJA)
Protein
Submitted name:
LDL receptor related protein 3
Gene
LRP3
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Biological processi
- negative regulation of fat cell differentiation Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of osteoblast differentiation Source: Ensembl
Keywordsi
Molecular function | ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: LDL receptor related protein 3ImportedSubmitted name: Low-density lipoprotein receptor-related protein 3Imported |
Gene namesi | Name:LRP3Imported |
Organismi | Callithrix jacchus (White-tufted-ear marmoset)Imported |
Taxonomic identifieri | 9483 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix › Callithrix |
Proteomesi |
|
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 497 – 523 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 166 ↔ 178 | PROSITE-ProRule annotation | ||
Disulfide bondi | 173 ↔ 191 | PROSITE-ProRule annotation | ||
Disulfide bondi | 185 ↔ 200 | PROSITE-ProRule annotation | ||
Disulfide bondi | 234 ↔ 249 | PROSITE-ProRule annotation | ||
Disulfide bondi | 437 ↔ 452 | PROSITE-ProRule annotation | ||
Disulfide bondi | 455 ↔ 467 | PROSITE-ProRule annotation | ||
Disulfide bondi | 462 ↔ 480 | PROSITE-ProRule annotation | ||
Disulfide bondi | 474 ↔ 489 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, LipoproteinImportedFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 159 | CUBInterPro annotationAdd BLAST | 117 | |
Domaini | 254 – 365 | CUBInterPro annotationAdd BLAST | 112 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 635 – 770 | DisorderedSequence analysisAdd BLAST | 136 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 692 – 706 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 724 – 741 | PolarSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160021 |
OMAi | LYMAQPH |
TreeFami | TF332149 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 4 hits |
Gene3Di | 2.60.120.290, 2 hits 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00057, Ldl_recept_a, 3 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 5 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 4 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01209, LDLRA_1, 3 hits PS50068, LDLRA_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
U3EYN1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKRAAPGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH
60 70 80 90 100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS
110 120 130 140 150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ
160 170 180 190 200
GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC
210 220 230 240 250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP
260 270 280 290 300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQE SRRVLLQLEL
310 320 330 340 350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR
360 370 380 390 400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD DDGGSAGDQG CFSEPQRCDG
410 420 430 440 450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YAPADRCNNQ KSCPDGADEK
460 470 480 490 500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA
510 520 530 540 550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
560 570 580 590 600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
610 620 630 640 650
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGLL QPAPEAAPNP
660 670 680 690 700
PAPLMDTGSP RAARDGPPSA PGHVLEVGPS GPPLPLGLQD PECRPMDKDR
710 720 730 740 750
KACREPLADS PAPVDAPREP CSAQDSHPQA STASSTLSPH SPEPLRVCRS
760 770
PPPHCSPMLE ASDDEALLVC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6VJR4 | F6VJR4_CALJA | LDL receptor related protein 3 | LRP3 | 761 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GAMT01004225 mRNA Translation: JAB07636.1 GAMS01003596 mRNA Translation: JAB19540.1 GAMQ01004711 mRNA Translation: JAB37140.1 GAMP01002823 mRNA Translation: JAB49932.1 |
Genome annotation databases
Ensembli | ENSCJAT00000063355; ENSCJAP00000041981; ENSCJAG00000000662 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GAMT01004225 mRNA Translation: JAB07636.1 GAMS01003596 mRNA Translation: JAB19540.1 GAMQ01004711 mRNA Translation: JAB37140.1 GAMP01002823 mRNA Translation: JAB49932.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9483.ENSCJAP00000041981 |
Genome annotation databases
Ensembli | ENSCJAT00000063355; ENSCJAP00000041981; ENSCJAG00000000662 |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160021 |
OMAi | LYMAQPH |
TreeFami | TF332149 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 4 hits |
Gene3Di | 2.60.120.290, 2 hits 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00057, Ldl_recept_a, 3 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 5 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 4 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01209, LDLRA_1, 3 hits PS50068, LDLRA_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | U3EYN1_CALJA | |
Accessioni | U3EYN1Primary (citable) accession number: U3EYN1 Secondary accession number(s): F7G4L4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2013 |
Last sequence update: | November 13, 2013 | |
Last modified: | April 7, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |