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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene

MED6

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6UniRule annotation
Alternative name(s):
Mediator complex subunit 6UniRule annotation
Gene namesi
Name:MED6Imported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3169 Eukaryota
COG5097 LUCA
KOiK15128
OrthoDBiEOG091G0MJA

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequencei

Sequence statusi: Complete.

U3EBM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV
60 70 80 90 100
KMQRLTLEHL NQMVGIEYIL LHAQEPILFI IRKQQRQSPA QVIPLADYYI
110 120 130 140 150
IAGVIYQAPD LGSVINSRVL TAVHGIQSAF DEAMSYCRYH PSKGYWWHFK
160 170 180 190 200
DHEEQDKVRP KAKRKEEPSS IFQRQRVDAL LVDLRQKFPP RFVQQKSGEK
210 220 230 240
PVPVDQTKKE AEPVPETVKS EEKETTKNVQ QTVSAKAPPE KRMRLQ
Length:246
Mass (Da):28,434
Last modified:November 13, 2013 - v1
Checksum:i545F22F30128CDA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01005621 mRNA Translation: JAB06240.1
GAMS01006046 mRNA Translation: JAB17090.1
GAMS01006045 mRNA Translation: JAB17091.1
GAMS01006044 mRNA Translation: JAB17092.1
GAMS01006043 mRNA Translation: JAB17093.1
GAMR01009812 mRNA Translation: JAB24120.1
GAMR01009811 mRNA Translation: JAB24121.1
GAMR01009810 mRNA Translation: JAB24122.1
GAMQ01007720 mRNA Translation: JAB34131.1
GAMQ01007719 mRNA Translation: JAB34132.1
GAMQ01007718 mRNA Translation: JAB34133.1
GAMP01010818 mRNA Translation: JAB41937.1
GAMP01010817 mRNA Translation: JAB41938.1
RefSeqiXP_002754106.1, XM_002754060.3

Genome annotation databases

GeneIDi100415022
KEGGicjc:100415022

Similar proteinsi

Entry informationi

Entry nameiU3EBM2_CALJA
AccessioniPrimary (citable) accession number: U3EBM2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: July 18, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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