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Protein
Submitted name:

WD repeat domain 44

Gene

WDR44

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
WD repeat domain 44Imported
Submitted name:
WD repeat-containing protein 44 isoform 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR44Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9483.ENSCJAP00000004439

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini506 – 822WD_REPEATS_REGIONInterPro annotationAdd BLAST317
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati506 – 541WDPROSITE-ProRule annotationAdd BLAST36
Repeati602 – 635WDPROSITE-ProRule annotationAdd BLAST34
Repeati642 – 676WDPROSITE-ProRule annotationAdd BLAST35
Repeati792 – 813WDPROSITE-ProRule annotationAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0283 Eukaryota
ENOG410XQPJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157557

KEGG Orthology (KO)

More...
KOi
K20241

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTDHTEV

Database of Orthologous Groups

More...
OrthoDBi
1332590at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329226

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040324 WDR44/Dgr2

The PANTHER Classification System

More...
PANTHERi
PTHR14221 PTHR14221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

U3E400-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASESDTEEF YDAPEDVHLG GGYLVGSPGK VGLSTFKETE NTAYKVGNES
60 70 80 90 100
PVQELKPDVS KKIIESIIEE SQKVLQLEDD SLDSKGKELS DQATASPIVA
110 120 130 140 150
RTDLSNIPGL LAIDQVLQEE SQAAESQNTF EETELELKKY FPSDETCEKP
160 170 180 190 200
IDETTKLTEV SSTEQLNVPE TETEVLNKEA VEVKGSDVLE PVSSDSLSTK
210 220 230 240 250
DFATGEEMAP AKPPRHLTPE PDIVASTKKP VPARPPPPTN FPPPRPPPPS
260 270 280 290 300
RPAPPPRKKK SELEFETLKT PDLDVPKENI TSDSLLTANM ASESTVKDSQ
310 320 330 340 350
PSLDLASATS GDKIVTAQEN GKGPDGQTIA GEVMGPQRPR SNSGRELTDE
360 370 380 390 400
EILASVMIKN LDTGEEIPLS LAEEKLPTGI NPLTLHIMRR TKEYVSNDAA
410 420 430 440 450
QSDDEEKLQS QPTDTDGGRL KQKTTQLKKF LGKSVKRAKH LAEEYGERAI
460 470 480 490 500
NKVKSVRDEV FHTDQDDPSS SDDEGMPYTR PVKFKAAHGF KGPYDFDQIK
510 520 530 540 550
VVQDLSGEHM GAVWTMKFSH CGRLLASAGQ DNVVRIWALK NAFDYFNNMR
560 570 580 590 600
MKYNTEGRVS PSPSQESLSS SKSDTDTGVC GGTDEDPDDK NAPFRQRPFC
610 620 630 640 650
KYKGHTADLL DLSWSKNYFL LSSSMDKTVR LWHISRRECL CCFQHIDFVT
660 670 680 690 700
AIAFHPRDDR YFLSGSLDGK LRLWNIPDKK VALWNEVDGQ TKLITAANFC
710 720 730 740 750
QNGKYAVIGT YDGRCIFYDT EHLKYHTQIH VRSTRGRNKV GRKITGIEPL
760 770 780 790 800
PGENKILVTS NDSRIRLYDL RDLSLSMKYK GYVNSSSQIK ASFSHDFTYL
810 820 830 840 850
VSGSEDKYVY IWSTYHDLSK FTSVRRDRND FWEGIKAHNA VVTSAIFAPN
860 870 880 890 900
PSLMLSLDVQ SEKSEGNEKS EDAEVLDATP SGIMKTDNTE VLLSADFTGA
910
IKVFINKRKT VS
Length:912
Mass (Da):101,345
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i281489F698BF6C83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YNA5F6YNA5_CALJA
WD repeat domain 44
WDR44
848Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YNJ4F6YNJ4_CALJA
WD repeat domain 44
WDR44
823Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GAMT01004595 mRNA Translation: JAB07266.1
GAMS01006511 mRNA Translation: JAB16625.1
GAMR01002808 mRNA Translation: JAB31124.1
GAMQ01004206 mRNA Translation: JAB37645.1
GAMP01007092 mRNA Translation: JAB45663.1

NCBI Reference Sequences

More...
RefSeqi
XP_002763240.1, XM_002763194.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCJAT00000004678; ENSCJAP00000004439; ENSCJAG00000002408

Database of genes from NCBI RefSeq genomes

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GeneIDi
100408891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cjc:100408891

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01004595 mRNA Translation: JAB07266.1
GAMS01006511 mRNA Translation: JAB16625.1
GAMR01002808 mRNA Translation: JAB31124.1
GAMQ01004206 mRNA Translation: JAB37645.1
GAMP01007092 mRNA Translation: JAB45663.1
RefSeqiXP_002763240.1, XM_002763194.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000004439

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCJAT00000004678; ENSCJAP00000004439; ENSCJAG00000002408
GeneIDi100408891
KEGGicjc:100408891

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54521

Phylogenomic databases

eggNOGiKOG0283 Eukaryota
ENOG410XQPJ LUCA
GeneTreeiENSGT00940000157557
KOiK20241
OMAiKTDHTEV
OrthoDBi1332590at2759
TreeFamiTF329226

Family and domain databases

InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040324 WDR44/Dgr2
PANTHERiPTHR14221 PTHR14221, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU3E400_CALJA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: U3E400
Secondary accession number(s): F6YN34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: January 16, 2019
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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