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Protein

Caveolin

Gene

CAV1

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CaveolinUniRule annotation
Gene namesi
Name:CAV1Imported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 129HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Golgi apparatusUniRule annotationSAAS annotation, Membrane

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiU3DG28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
KOiK06278
OMAiSICIHTF
OrthoDBiEOG091G0M1R

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequencei

Sequence statusi: Complete.

U3DG28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YIHTVCDPLF EAIGKIFSNV RISLQKEI
Length:178
Mass (Da):20,473
Last modified:November 13, 2013 - v1
Checksum:iC8F4C06AB174D1CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01000150 mRNA Translation: JAB11711.1
GAMS01007507 mRNA Translation: JAB15629.1
GAMS01007506 mRNA Translation: JAB15630.1
GAMR01002190 mRNA Translation: JAB31742.1
GAMQ01004268 mRNA Translation: JAB37583.1
GAMP01004564 mRNA Translation: JAB48191.1
RefSeqiXP_002751813.1, XM_002751767.4

Genome annotation databases

GeneIDi100407940
KEGGicjc:100407940

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01000150 mRNA Translation: JAB11711.1
GAMS01007507 mRNA Translation: JAB15629.1
GAMS01007506 mRNA Translation: JAB15630.1
GAMR01002190 mRNA Translation: JAB31742.1
GAMQ01004268 mRNA Translation: JAB37583.1
GAMP01004564 mRNA Translation: JAB48191.1
RefSeqiXP_002751813.1, XM_002751767.4

3D structure databases

SMRiU3DG28
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100407940
KEGGicjc:100407940

Organism-specific databases

CTDi857

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
KOiK06278
OMAiSICIHTF
OrthoDBiEOG091G0M1R

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU3DG28_CALJA
AccessioniPrimary (citable) accession number: U3DG28
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: November 7, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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