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Protein
Submitted name:

Optineurin

Gene

OPTN

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
OptineurinImported
Gene namesi
Name:OPTNImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini548 – 578CCHC NOA-typeInterPro annotationAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 64Sequence analysisAdd BLAST21
Coiled coili76 – 124Sequence analysisAdd BLAST49
Coiled coili133 – 160Sequence analysisAdd BLAST28
Coiled coili234 – 261Sequence analysisAdd BLAST28
Coiled coili307 – 334Sequence analysisAdd BLAST28
Coiled coili352 – 372Sequence analysisAdd BLAST21
Coiled coili387 – 407Sequence analysisAdd BLAST21
Coiled coili417 – 458Sequence analysisAdd BLAST42
Coiled coili476 – 496Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE97 Eukaryota
ENOG410Z0DF LUCA

Family and domain databases

InterProiView protein in InterPro
IPR032419 CC2-LZ_dom
IPR021063 NEMO_N
IPR034735 NEMO_ZF
IPR032939 Optineurin
PANTHERiPTHR31553:SF2 PTHR31553:SF2, 1 hit
PfamiView protein in Pfam
PF16516 CC2-LZ, 1 hit
PF11577 NEMO, 1 hit
PROSITEiView protein in PROSITE
PS51801 ZF_CCHC_NOA, 1 hit

Sequencei

Sequence statusi: Complete.

U3B2U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHQPLSCLT EKGASPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE
60 70 80 90 100
NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL
110 120 130 140 150
SQENEKLKEE LGKLKGKSER SSGEPNGDSM LPTAEAEQEK EQLRTQVVRL
160 170 180 190 200
QAEKADLLGI VSELQLKLNS SGSSEDSFIE IRMAEGEAEG SVKEIKHSPG
210 220 230 240 250
PTRTVSIGMS RSAEGAKNYL EHEELTVRQL LLCLREGNQK VERLEIALKE
260 270 280 290 300
AKERISDFEK KASNRSEVET QTDGSTEKEN EEEKGAETVG SEVEALNLQV
310 320 330 340 350
TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY
360 370 380 390 400
HNKKLELQVE SMLSEIKMEQ AKTEEEKSKL AMLQLTHNKL LQEHNKALKT
410 420 430 440 450
IEELTRKESE TVDRSVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE
460 470 480 490 500
DLETMSILRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDVF
510 520 530 540 550
EDGGSVAFHP SRQSLMEMQS RHGARTSDAD QQAYLVQRGA EDRDWRQQRN
560 570
IPIHSCPKCG EVLPDIDTLQ IHVMDCII
Length:578
Mass (Da):65,709
Last modified:November 13, 2013 - v1
Checksum:i40C60344345A3A62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01004898 mRNA Translation: JAB06963.1
RefSeqiXP_008998190.1, XM_008999942.2

Genome annotation databases

GeneIDi100398129

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMT01004898 mRNA Translation: JAB06963.1
RefSeqiXP_008998190.1, XM_008999942.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100398129

Organism-specific databases

CTDi10133

Phylogenomic databases

eggNOGiENOG410IE97 Eukaryota
ENOG410Z0DF LUCA

Family and domain databases

InterProiView protein in InterPro
IPR032419 CC2-LZ_dom
IPR021063 NEMO_N
IPR034735 NEMO_ZF
IPR032939 Optineurin
PANTHERiPTHR31553:SF2 PTHR31553:SF2, 1 hit
PfamiView protein in Pfam
PF16516 CC2-LZ, 1 hit
PF11577 NEMO, 1 hit
PROSITEiView protein in PROSITE
PS51801 ZF_CCHC_NOA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU3B2U7_CALJA
AccessioniPrimary (citable) accession number: U3B2U7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: December 20, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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