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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Campylobacter concisus ATCC 51562
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
ORF Names:ATCC51562_748Imported
OrganismiCampylobacter concisus ATCC 51562Imported
Taxonomic identifieri1242969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000016627 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei227N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 351Aminotran_1_2InterPro annotationAdd BLAST321

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

U2F5G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNDFLDDL VNYEAGKPIE LVVREFGIEA KDVIKLASNE NPFGTSKRVE
60 70 80 90 100
EALKEVAKKA HLYPDDSYFE LKEGLAKKFG VTSKNLIIGS GSDQIIEYAL
110 120 130 140 150
HAKANKQSGV LMAGVTFAMY EIYAKQTGAK IYRTKSVEHN LSEFLEIYNA
160 170 180 190 200
HKDEISVIFL CLPNNPLGEC LDADEVFKFI KSIDENTLVV FDCAYNEFAK
210 220 230 240 250
FKDSKKEIKP SEVVKFKNAI YLGTFSKAYA LGGMRVGYGV ANEEIIGALS
260 270 280 290 300
KLRAPFNITT PSLRAAIVAL NDDEFVQQTM QNNFEQMKRY EEFAKQNGIE
310 320 330 340 350
FIPSYTNFIT FKFNEPKSSQ ICEKMLKKGI ILRDLKSYAL NAVRITIGLS
360
WQNDRVFEEL KQILK
Length:365
Mass (Da):41,381
Last modified:November 13, 2013 - v1
Checksum:i6C5B706A4D0EA582
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ANNI01000009 Genomic DNA Translation: ERJ25165.1
RefSeqiWP_021091638.1, NZ_ANNI01000009.1

Genome annotation databases

EnsemblBacteriaiERJ25165; ERJ25165; ATCC51562_748
PATRICifig|1242969.3.peg.1546

Similar proteinsi

Entry informationi

Entry nameiU2F5G3_9PROT
AccessioniPrimary (citable) accession number: U2F5G3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: April 25, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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