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Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

J07HB67_01285

Organism
halophilic archaeon J07HB67
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha (J07HB67_01285)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei247Tele-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Gene namesi
ORF Names:J07HB67_01285Imported
Organismihalophilic archaeon J07HB67Imported
Taxonomic identifieri1085029 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacteriales
Proteomesi
  • UP000030674 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 100CoA_bindingInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.261, 1 hit
HAMAPiMF_01988 Succ_CoA_alpha, 1 hit
InterProiView protein in InterPro
IPR017440 Cit_synth/succinyl-CoA_lig_AS
IPR033847 Citrt_syn/SCS-alpha_CS
IPR003781 CoA-bd
IPR005810 CoA_lig_alpha
IPR005811 CoA_ligase
IPR036291 NAD(P)-bd_dom_sf
IPR016102 Succinyl-CoA_synth-like
PfamiView protein in Pfam
PF02629 CoA_binding, 1 hit
PF00549 Ligase_CoA, 1 hit
PIRSFiPIRSF001553 SucCS_alpha, 1 hit
SMARTiView protein in SMART
SM00881 CoA_binding, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52210 SSF52210, 1 hit
TIGRFAMsiTIGR01019 sucCoAalpha, 1 hit
PROSITEiView protein in PROSITE
PS01216 SUCCINYL_COA_LIG_1, 1 hit
PS00399 SUCCINYL_COA_LIG_2, 1 hit

Sequencei

Sequence statusi: Fragment.

U1PP97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLVDGDTR VVVQGITGGE GEFHTEQMID YGTNVVAGAV PGRGGQTVAG
60 70 80 90 100
VPVYDTVERA AEAEDADASV IFVPPAFAAD AVFEALDAPV DLAVAITEGV
110 120 130 140 150
PTQDMAAVNA ALSDSETRLV GPNCPGVITP GAAKLGILPG NVFEPGSVGL
160 170 180 190 200
VSRSGTLTYQ VVSNLTDRGL GQSTAIGIGG DPIIGTSFVD ALELFEADPD
210 220 230 240 250
TDAIVMCGEI GGEDEERAAA FIDDHVDTPV AGFVAGRTAP PGKRMGHAGA
260 270 280
IVSGSGTGTA QSKIDALTDA GVPVGDTPAE VAT
Length:283
Mass (Da):28,274
Last modified:November 13, 2013 - v1
Checksum:i836CD2E72AD7949E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei283Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE356582 Genomic DNA Translation: ERH12271.1

Similar proteinsi

Entry informationi

Entry nameiU1PP97_9EURY
AccessioniPrimary (citable) accession number: U1PP97
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: July 18, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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