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Entry version 16 (05 Jun 2019)
Sequence version 1 (13 Nov 2013)
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Protein
Submitted name:

1,3-beta-glucan synthase component FKS1

Gene

BDFG_09010

Organism
Blastomyces dermatitidis ATCC 26199
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
1,3-beta-glucan synthase component FKS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BDFG_09010Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBlastomyces dermatitidis ATCC 26199Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri447095 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeBlastomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000053869 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei526 – 548HelicalSequence analysisAdd BLAST23
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Transmembranei600 – 622HelicalSequence analysisAdd BLAST23
Transmembranei655 – 677HelicalSequence analysisAdd BLAST23
Transmembranei712 – 736HelicalSequence analysisAdd BLAST25
Transmembranei1386 – 1407HelicalSequence analysisAdd BLAST22
Transmembranei1503 – 1521HelicalSequence analysisAdd BLAST19
Transmembranei1592 – 1614HelicalSequence analysisAdd BLAST23
Transmembranei1634 – 1656HelicalSequence analysisAdd BLAST23
Transmembranei1668 – 1692HelicalSequence analysisAdd BLAST25
Transmembranei1698 – 1717HelicalSequence analysisAdd BLAST20
Transmembranei1825 – 1849HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini335 – 447FKS1_dom1InterPro annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 113DisorderedSequence analysisAdd BLAST113
Regioni137 – 159DisorderedSequence analysisAdd BLAST23
Regioni286 – 310DisorderedSequence analysisAdd BLAST25
Regioni1879 – 1906DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 46PolarSequence analysisAdd BLAST46
Compositional biasi92 – 109PolyampholyteSequence analysisAdd BLAST18
Compositional biasi294 – 310PolyampholyteSequence analysisAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
48442at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

T5B5Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVQPQGGGG AQNGNGYGDG YPQNTPGDSY YQDGYYEQND YSQHDGYYDN
60 70 80 90 100
QGYGDQYQQD GYYDNQQGYD DEYYNDQYYD QGTAGYYNGA HPGRRRGHDS
110 120 130 140 150
EEDSETFSDF TMKSETARAA DMDYYGRGDE RYNSYNEHQM GGRGYRPPSS
160 170 180 190 200
QISYGANRSS GASTPVYGLD YGNALPAGQR SREPYPAWTS DAQIPISKEE
210 220 230 240 250
IEDIFLDLVN KFGFQRDSMR NMYDHFMTLL DSRASRLTPN QALLSLHADY
260 270 280 290 300
IGGDNANYRR WYFAAHLDLD DAVGFANMKL GKGNRKTRKA RKAAKKAAGN
310 320 330 340 350
DPKNEEETLA DMEGDNSLEA AEYRWKTRMN RMSQHERARQ IALYLLCWGE
360 370 380 390 400
ANQVRFMPEA LCFIFKCADD YYHSPECQNR VEPVEEFTYL NDIITPLYQY
410 420 430 440 450
CRDQGYEIFD GKYVRREKDH NKIIGYDDIN QLFWYPEGIE RIVMNDKSRI
460 470 480 490 500
VDVPPAQRYQ KLKDVNWKKV FFKTYKETRS WFHMMVNFNR IWVIHVGAFW
510 520 530 540 550
FYTAFNSPTL YTREYKQLEN NPPTAAARWT ATGLGGAVAT FIMIFATICE
560 570 580 590 600
WCYVPRAWAG AQHLTKRLLF LIGIFCINIG PAVFVFGVTQ DHKASHVLGV
610 620 630 640 650
VSFFVNLATF FFFSVMPLGG LFGSYMRKNS RQYVASQTFT ASYPRLRGND
660 670 680 690 700
MWMSYGLWVC VFGVKLAESY FFLTLSFRDP IRILSQMKIN QCAGDKLFGA
710 720 730 740 750
SADVLCKAQP RILLGLMFFT DLSLFFLDTY LCYVILNAVF SVARSFYLGV
760 770 780 790 800
SIWTPWRNIF SRLPKRIYSK VLATTDMEIK YKPKVLISQV WNAIVISMYR
810 820 830 840 850
EHLLAIDHVQ KLLYHQVPSE QEGKRTLRAP TFFVSQEDNS FKTEFFPTQS
860 870 880 890 900
EAERRISFFA QSLSTPIPEP VPVDNMPTFT VLIPHYSEKI LLSLREIIRE
910 920 930 940 950
DEPYSRVTLL EYLKQLHPHE WDCFVKDTKI LADETSQFNG DEKSEKDAAK
960 970 980 990 1000
TKIDDLPFYC IGFKSAAPEY TLRTRIWASL RSQTLYRTIS GFMNYSRAIK
1010 1020 1030 1040 1050
LLYRVENPEV VQMFGGNSEK LERELERMAR RKFRIVVSMQ RFAKFNKEER
1060 1070 1080 1090 1100
ENTEFLLRAY PDLQIAYLDE EPPANEGEEP RLYSALIDGH SEIMENGLRR
1110 1120 1130 1140 1150
PKFRIQLSGN PILGDGKSDN QNHAIIFYRG EYIQLIDANQ DNYLEECLKI
1160 1170 1180 1190 1200
RSVLAEFEEM NPENVSPYVP GLPPAKTNPV AILGAREYIF SENIGILGDV
1210 1220 1230 1240 1250
AAGKEQTFGT LFARTLAQIG GKLHYGHPDF LNGIFMTTRG GVSKAQKGLH
1260 1270 1280 1290 1300
LNEDIYAGMN ALLRGGRIKH CEYYQCGKGR DLGFGSVLNF TTKIGTGMGE
1310 1320 1330 1340 1350
QMLSREYYYL GTQLPLDRFL SFYYAHPGFH INNLFIMFSV QMFMICLTNL
1360 1370 1380 1390 1400
GALRNQTIPC IVKKGVPITD RLLPTGCADT DPIQAWVNRC IASICIVFLL
1410 1420 1430 1440 1450
SFFPLVVQEL TERGAWRALT RLAKHFGSLS PFFEVFVCQI YANSLHNNLS
1460 1470 1480 1490 1500
FGGARYIGTG RGFATARIPF GVLYSRFAGP SIYLGARLLM MLLFSTLTVW
1510 1520 1530 1540 1550
AGWLLYFWAS LLALCISPFL FNPHQFAWND FFIDYRDYLR WLSRGNSRSH
1560 1570 1580 1590 1600
ASSWIAFCRL SRTRITGYKR KVLGTPSEKL SGDAPRAQLT NIFFSEIVGP
1610 1620 1630 1640 1650
LVLVAVTLIP YLFINAQTGV KDAKPTSSLI RLAIVAFAPI AINAGCLAIL
1660 1670 1680 1690 1700
FAMACCMGPV LSMCCKKFGS VLAAIAHGVA VVMLLAFFEV MFFLEGWVFA
1710 1720 1730 1740 1750
KALLGMIAVV AVQRFFYKLI ISLALTREFR HDTSNVAWWT GKWYSMGWHS
1760 1770 1780 1790 1800
MSQPGREFLC KITELGMFAA DFILGHVLLF FMLPPLCIPY VDKGHSVMLF
1810 1820 1830 1840 1850
WLRPSRQIRP PIYSLKQSKL RKRRVIRFAI LYFFMLVVFL GLIVGPVVAG
1860 1870 1880 1890 1900
PRINKISLPA LINDLSLLQP TGQDINDTTT SLTGKALNDP APKSTGSNNN

RMARLF
Length:1,906
Mass (Da):217,688
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3761D418F994F32D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL538562 Genomic DNA Translation: EQL28222.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EQL28222; EQL28222; BDFG_09010

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL538562 Genomic DNA Translation: EQL28222.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEQL28222; EQL28222; BDFG_09010

Phylogenomic databases

OrthoDBi48442at2759

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT5B5Q7_AJEDE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: T5B5Q7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: June 5, 2019
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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