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Entry version 30 (07 Oct 2020)
Sequence version 1 (13 Nov 2013)
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Protein
Submitted name:

Transcriptional-regulating factor 1

Gene

TRERF1

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transcriptional-regulating factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRERF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHydra vulgaris (Hydra) (Hydra attenuata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6087 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 100C2H2-typeInterPro annotationAdd BLAST28
Domaini101 – 128C2H2-typeInterPro annotationAdd BLAST28
Domaini129 – 154C2H2-typeInterPro annotationAdd BLAST26
Domaini731 – 820ELM2InterPro annotationAdd BLAST90
Domaini835 – 886SANTInterPro annotationAdd BLAST52
Domaini926 – 955C2H2-typeInterPro annotationAdd BLAST30
Domaini1006 – 1033C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 70DisorderedSequence analysisAdd BLAST70
Regioni192 – 234DisorderedSequence analysisAdd BLAST43
Regioni407 – 431DisorderedSequence analysisAdd BLAST25
Regioni517 – 541DisorderedSequence analysisAdd BLAST25
Regioni708 – 727DisorderedSequence analysisAdd BLAST20
Regioni950 – 992DisorderedSequence analysisAdd BLAST43
Regioni1022 – 1053DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 70PolarSequence analysisAdd BLAST64
Compositional biasi414 – 431PolarSequence analysisAdd BLAST18
Compositional biasi955 – 969PolyampholyteSequence analysisAdd BLAST15
Compositional biasi970 – 992PolarSequence analysisAdd BLAST23
Compositional biasi1039 – 1053PolarSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
165439at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448, ELM2, 1 hit
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

T2M6K0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKSTRPSHL GSNFVPQTQF LSVNVSHGTP GSDKDSNTSS VSPVQNSPYG
60 70 80 90 100
NSERQSSRTP SPQSDRSKLK TENTCLQCQK HFSSSSALAK HKLIHSDERK
110 120 130 140 150
YVCHICSRGF KRQDHLNGHM ITHRDKKPYE CHFPECRKSY CDMRSLKRHL
160 170 180 190 200
ENNHGSPIGG ATPGYLAENS TLYPAFPTVS RSSDIIHRPY LKVESDKRPQ
210 220 230 240 250
SNEPVRPSSA PTAAPEPQRI IRTRRSSSVE DHSMSLDPDL LKEFDLRKKS
260 270 280 290 300
RQMAKELRDH EPIQLGSFSQ SNSCATSNHF IMSTGVSTST EASYSRNNDY
310 320 330 340 350
ARSSEKYEQR SFEHHQIPHV THSKIFSPGR VITHQENNHN LSKDKTDYVQ
360 370 380 390 400
AHFPSISQNM PPQLNPRFAW HPHYSGNRQI QSPCTSMPYL MTKPVFRPYS
410 420 430 440 450
PHGLCRSHDD FPSMPRNEAS TPNKNDHDPG EQAVSTFLQM QYFLKESYAL
460 470 480 490 500
GHKNHTPTDP TAIAIATAKE HIDYRQPFHA ARDSYYGIQP YNAEWQTVTK
510 520 530 540 550
NDPSVQDASY HSFYHKQQLN SQTESKKDSY QASQSTSNQS QYSLFNVNDR
560 570 580 590 600
NIEPFKVNKE SNVEHRLGYT LQQSNDKIRQ FDQSKNFDPL YITVNHSLVP
610 620 630 640 650
PRQNNQPAFE SKVKIDETFN HITSPVSPNK KRSRPSPIVI PVLTNRSNFT
660 670 680 690 700
GPSSPTCGFQ SVAKAVYTPP AMLSPQSIFF NPQATPKNVV PQAPARYLLS
710 720 730 740 750
SRRSTSIDQR DLSVTTKASP EDQGVPEIHE PKINIGIQFQ AALPNISDRS
760 770 780 790 800
DAQKDIHRAS LMWSPLKADV SKDAEVDSYL EMACSLGLYG GSNNKEYALH
810 820 830 840 850
ILQRTRGNVK EAVRLLLSRR HILRADDPNA DYHYSGSVRW TAKERLTFRQ
860 870 880 890 900
AYRTKGKLFS AIQADVGTKS VYLCVEFYYL WKAMHPESFR ARTRAVEVES
910 920 930 940 950
DQDDEEVPPT PTAAVAPLST LREPVFECDY PECRARFVSR QALNGHIRIH
960 970 980 990 1000
GGSFMKPTDA RRSKPKVSGH STVLDDSTSP SNSKKKKNTP TSVIVTSKGE
1010 1020 1030 1040 1050
APLLQFQCKV CGRVFSKVKS RSAHMKTHVK RDENNKPIKQ IKSSPANSTA

VFC
Length:1,053
Mass (Da):119,014
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i268E2C385D6B905F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HAAD01001686 mRNA Translation: CDG67918.1

NCBI Reference Sequences

More...
RefSeqi
XP_002158382.2, XM_002158346.3
XP_012557452.1, XM_012701998.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100209907

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hmg:100209907

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HAAD01001686 mRNA Translation: CDG67918.1
RefSeqiXP_002158382.2, XM_002158346.3
XP_012557452.1, XM_012701998.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100209907
KEGGihmg:100209907

Phylogenomic databases

OrthoDBi165439at2759

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2M6K0_HYDVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: T2M6K0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: October 7, 2020
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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