Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 23 (11 Dec 2019)
Sequence version 1 (13 Nov 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Patched domain-containing protein 2

Gene

PTCHD2

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Patched domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTCHD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHydra vulgaris (Hydra) (Hydra attenuata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6087 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 27HelicalSequence analysisAdd BLAST22
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei326 – 347HelicalSequence analysisAdd BLAST22
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei394 – 417HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini332 – 416SSDInterPro annotationAdd BLAST85
Domaini788 – 1062Reverse transcriptaseInterPro annotationAdd BLAST275

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030223 Dispatched
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR003392 Ptc/Disp
IPR000477 RT_dom
IPR000731 SSD

The PANTHER Classification System

More...
PANTHERi
PTHR45951:SF3 PTHR45951:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529 Exo_endo_phos_2, 1 hit
PF02460 Patched, 1 hit
PF00078 RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

T2M4I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HLVFFFSAVG LCIQISLVFT TAGLYIFDYD IFPYDFTQVP LNLEMDSTKL
60 70 80 90 100
RADAFNFVVE DGRINLQPVT AISQGERNIK AAPLELVYRC KDLKKNVITA
110 120 130 140 150
KNLKSITELE KELFLNPMYQ RVCHLMNLNN SMVCSPPMSL IHLFDGTYRS
160 170 180 190 200
IDPVFYDPDF KNITSVLNLA KNISELRPLL AFSFDKNSVL ENNRIFSTHL
210 220 230 240 250
RSLLFAGLPL HGYRHAEDRK NEQLLSLKKY IVEGFGKLLA DRYKSGVGEL
260 270 280 290 300
NVFYMNLELF FNAVEKQVIW DLLLAGGSLV FIFCFIWFQT GSLWITGWAI
310 320 330 340 350
FSIITNFFGA NLIYRIILDF RYIGIFHVLS VFIILGIGAD DVFVFYNTWK
360 370 380 390 400
LMENEKFNCL QKHLTETFRI ASGAMFVTSL TTAVAFFASA TSPLLGVSSF
410 420 430 440 450
GVFSALLHSI TFLFVLYRSP SSHDCTLLDV ISDQIDHALS LYPSANIVVV
460 470 480 490 500
GDFNAHHTEW LGSNTTDPAG TKAFNFCVSQ SLTMIVNFVT RFPDNPNHLP
510 520 530 540 550
SLLDLCLVSD PSLCSVSPFS PLGGSDHAMI SINLSSRTSF LGSPYHRTTY
560 570 580 590 600
YYPKADWDSF RDFLRDGPWA DVFSLSADKC TITSWIQAGM EAFIPSRRFQ
610 620 630 640 650
VKPHSTPWFS PSCAAAISNR NHFFHLFQKN NSLENKRLFI IARNRCKKVL
660 670 680 690 700
SDAKLHYSQF TKSLILSQKL GSKDFWKIFN SIINKGRSNI PSLIHGTDLI
710 720 730 740 750
TSPKDKAELF AKNFSSNSTL ESYGHSLTSI PVKQVDPLLD IQITPASVAK
760 770 780 790 800
VISQLNSSTA CGPDNIPVTV LQNCSPELSS ILSKLFNKCL TESCFSACWK
810 820 830 840 850
MASVVPIFKN SGENSDPSNC RPISLLSVIS KVFESLINKF LTSHLESNKL
860 870 880 890 900
LSDNQYGFRS SRSTADLLTA VTERFYRALD GGSEARAIAL DISKAFDKVW
910 920 930 940 950
HAGLLHKLAS YGVSGKVFES IKSFLSNRFI KVILEGQHSS LFPVTSGVPQ
960 970 980 990 1000
GSILGPVLFL IYINDLPDNL SSKVALFADD STLYSCLDKK SSLFDRLEQA
1010 1020 1030 1040 1050
ADLESDLTSV IDWGSQWLVN FNSKKTQLLT ANNYRNMVNI PILMNGNPLT
1060 1070 1080 1090 1100
ELSSLRLLGL SVTTDLSWKP YIQSIAKLAS AKVASLYRAR HFLTSDSILY
1110 1120 1130 1140 1150
LYKSLIRPCM EYCCHIWAGS SNDSLSLLDK VQKRIVNVVG PGLSAKLEPL

SHRR
Length:1,154
Mass (Da):129,233
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i600FCFCF604749B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HAAD01000593 mRNA Translation: CDG66825.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HAAD01000593 mRNA Translation: CDG66825.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR030223 Dispatched
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR003392 Ptc/Disp
IPR000477 RT_dom
IPR000731 SSD
PANTHERiPTHR45951:SF3 PTHR45951:SF3, 1 hit
PfamiView protein in Pfam
PF14529 Exo_endo_phos_2, 1 hit
PF02460 Patched, 1 hit
PF00078 RVT_1, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2M4I6_HYDVU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: T2M4I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: December 11, 2019
This is version 23 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again