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Entry version 31 (29 Sep 2021)
Sequence version 1 (13 Nov 2013)
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Protein

Beta-glucuronidase

Gene

BN863_22060

Organism
Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta-glucuronidase involved in ulvan degradation (PubMed:31285597).

Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable). Beta-glucuronidase removes GlcA side chains present on some O2 residues of Rha3S. Can remove the GlcA side chains from polymeric ulvan or from smaller oligomers (PubMed:31285597).

1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei500Nucleophile1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi561Magnesium1 Publication1
Metal bindingi562Magnesium; via carbonyl oxygen1 Publication1
Metal bindingi563Magnesium; via carbonyl oxygen1 Publication1
Metal bindingi581Magnesium; via carbonyl oxygen1 Publication1
Metal bindingi583Magnesium1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-glucuronidaseCurated (EC:3.2.1.311 Publication)
Alternative name(s):
Glycosyl hydrolase 2 family protein P17Curated
Short name:
P17_GH21 Publication
Polysaccharide utilization locus H protein P171 Publication
Short name:
PUL H protein P17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BN863_22060
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFormosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1347342 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFormosa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000016160 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004483011 – 981Beta-glucuronidaseAdd BLAST981

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ulvan and rhamnose.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1347342.BN863_22060

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1981
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
T2KN75

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3250, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006501_3_0_10

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036156, Beta-gal/glucu_dom_sf
IPR032311, DUF4982
IPR008979, Galactose-bd-like_sf
IPR040605, Glyco_hydro2_dom5
IPR006103, Glyco_hydro_2_cat
IPR006102, Glyco_hydro_2_Ig-like
IPR006104, Glyco_hydro_2_N
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16355, DUF4982, 1 hit
PF18565, Glyco_hydro2_C5, 1 hit
PF00703, Glyco_hydro_2, 1 hit
PF02836, Glyco_hydro_2_C, 1 hit
PF02837, Glyco_hydro_2_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49303, SSF49303, 1 hit
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

T2KN75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTILCSCAQQ QQQQQQDTEV ITSSERTTYN FNVDWKFIKS NPKQAQDINY
60 70 80 90 100
NDATWETISC PHTFNDVDTF DDLSHGHHDG EDNQWRGTVW YRKHFKLPKD
110 120 130 140 150
DKGKKVFIEF ESVRQIADVY INGVHLGQNQ TGFIPFGFDL TPHLKFGEEN
160 170 180 190 200
IIAVKVNNDR GDHFRENFPL VWNHEHWHPT HGGIYRNVFL HTMDPLHITL
210 220 230 240 250
PLYDNLETVG TYVYAENISE KSADITVETE IQNEHAENKN ITLVTQIVDN
260 270 280 290 300
DGAVVAHSNK NVAIPSGQKM KVTTVTNIQN PQLWYTRYPY MYKVVSAIKE
310 320 330 340 350
SNKVIDTYES PLGIRNFDFN KDSGFWINGE QIKLHGWGQK PTNAWAGLGA
360 370 380 390 400
ALPDWLRDFT FKLMDEAGGN FIRWGHCAAS PAEVDMGDKY GFVTLMPGVS
410 420 430 440 450
GESEDEGETW DIRYKAFKDL IVYYRNHPSI FIWEGGNWAE SEAHYKEILE
460 470 480 490 500
AIKTFDPKGK RLMGNRRADV KNDSEGYVSI EIGTEGWERE YPDLPIIESE
510 520 530 540 550
YNREEAPRRI WDKNSPDDNF YNHPNISKNT YKLSSEEFAV RQADHWWNKM
560 570 580 590 600
GKKAYHSGGA NWIFSDGPHG GRCPTEVTRA SGEVDAVRLP KEAFYALKAM
610 620 630 640 650
WRPEPQVHIV GHWNYEVGTK KTMYVMSNCA SVKLYVNDKL VGTNSNPENG
660 670 680 690 700
YVFKFDNVAW ESGKIKAEGF IDDALKTTQT KETTGEPAAL KLTSITGPEG
710 720 730 740 750
WLADGSDVAL IDVEVVDAQG RRCPLAKGRV DFTISGPAIW RGGYNSGKPN
760 770 780 790 800
STNNLFLDIE AGINRVAVRS VLESGTVTIM AKKPGFKDVS VTLKSLPIDF
810 820 830 840 850
NNGLTTTLPQ VYTNVLTKEP LPEHIPEMPE YIPGVKNRSE LFRKFSYTGD
860 870 880 890 900
GKAMLRTNMH WGKKAYTDLE YNYTVLPRYL NESEYVRTPN SDNRYWARDQ
910 920 930 940 950
LQFIAGKKMH IYVLHDDTVP RPEFLLRDYE DTGDNVNVVG ASMSVFHRVA
960 970 980
EEGESIIMAG NSDGDAPENC RMYTVMVKEF K
Length:981
Mass (Da):111,684
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E788F28A18AEAA3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HG315671 Genomic DNA Translation: CDF79918.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CDF79918; CDF79918; BN863_22060

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1347342.6.peg.2213

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG315671 Genomic DNA Translation: CDF79918.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HPDX-ray2.43A19-981[»]
SMRiT2KN75
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi1347342.BN863_22060

Genome annotation databases

EnsemblBacteriaiCDF79918; CDF79918; BN863_22060
PATRICifig|1347342.6.peg.2213

Phylogenomic databases

eggNOGiCOG3250, Bacteria
HOGENOMiCLU_006501_3_0_10

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156, Beta-gal/glucu_dom_sf
IPR032311, DUF4982
IPR008979, Galactose-bd-like_sf
IPR040605, Glyco_hydro2_dom5
IPR006103, Glyco_hydro_2_cat
IPR006102, Glyco_hydro_2_Ig-like
IPR006104, Glyco_hydro_2_N
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF16355, DUF4982, 1 hit
PF18565, Glyco_hydro2_C5, 1 hit
PF00703, Glyco_hydro_2, 1 hit
PF02836, Glyco_hydro_2_C, 1 hit
PF02837, Glyco_hydro_2_N, 1 hit
SUPFAMiSSF49303, SSF49303, 1 hit
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLH17_FORAG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: T2KN75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2019
Last sequence update: November 13, 2013
Last modified: September 29, 2021
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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