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Entry version 34 (31 Jul 2019)
Sequence version 1 (13 Nov 2013)
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Protein

DIS3-like exonuclease 2

Gene

CNAG_03345

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.UniRule annotation

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1126MagnesiumUniRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1134Important for catalytic activityUniRule annotation1
Metal bindingi1135MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonucleaseUniRule annotation, Hydrolase, Nuclease, RNA-bindingUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DIS3-like exonuclease 2UniRule annotation (EC:3.1.13.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_03345Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNAG_03345

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
T2BN03

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1114 – 1452RNBInterPro annotationAdd BLAST339

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 271DisorderedSequence analysisAdd BLAST271
Regioni287 – 331DisorderedSequence analysisAdd BLAST45
Regioni476 – 550DisorderedSequence analysisAdd BLAST75
Regioni627 – 667DisorderedSequence analysisAdd BLAST41
Regioni709 – 737DisorderedSequence analysisAdd BLAST29
Regioni978 – 1005DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili396 – 416Sequence analysisAdd BLAST21
Coiled coili451 – 471Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 63PolarSequence analysisAdd BLAST55
Compositional biasi71 – 91PolarSequence analysisAdd BLAST21
Compositional biasi96 – 128PolyampholyteSequence analysisAdd BLAST33
Compositional biasi138 – 163PolarSequence analysisAdd BLAST26
Compositional biasi217 – 248PolarSequence analysisAdd BLAST32
Compositional biasi532 – 550PolarSequence analysisAdd BLAST19
Compositional biasi627 – 649PolarSequence analysisAdd BLAST23
Compositional biasi718 – 737PolarSequence analysisAdd BLAST20
Compositional biasi982 – 1005PolyampholyteSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNR ribonuclease family. DIS3L2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03045 DIS3L2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041505 Dis3_CSD2
IPR028591 DIS3L2
IPR041093 Dis3l2_C
IPR012340 NA-bd_OB-fold
IPR001900 RNase_II/R

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17877 Dis3l2_C_term, 1 hit
PF17849 OB_Dis3, 1 hit
PF00773 RNB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00955 RNB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

T2BN03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPLSPAPD HQSQATLAPP VHPSRPSSAN SQKSNSSRSR GKNANGGSSN
60 70 80 90 100
MSRTNSNTSG QSDSGRSDKK RQSGPTTTIS GGVSLGVSGE APQQNKKGKG
110 120 130 140 150
KGKNQDKEKE GEKKGASMEV EKPQKNSSQK GKRSASGRKP HPINTNESSR
160 170 180 190 200
TVSRNSEHEN MPADAGSSQP APGPKSIHAP VSAPRTAIEA AVEAATKKHR
210 220 230 240 250
SQTGGDALAS LQKMISDLKT LPATSGPGSG SSAGSRSTSV TRDPPSTSSA
260 270 280 290 300
KAEPVAIPSA LNSGSHKALK ADAPTFTPSF QSFSPVASTS GLSVSPNNTM
310 320 330 340 350
PTLAQLHPRS QSQSNGAHHR RNSASSMSSV NFAPPFNPSP IQAFGNPLPP
360 370 380 390 400
FYQTPLSVHA EADDESLSPL SFAQHATFQY QQQQLLAAQQ QQYQYIQLLQ
410 420 430 440 450
AQLAASQLAH QQAQQAAQHQ NQQMGNFIAP RFQALAAQRA ASQQQQQASQ
460 470 480 490 500
LAQAQQVFEL QQAQLLQQQE EATRASVRAA AEAAHPQNQP VFEEESPELQ
510 520 530 540 550
PHTVGTSGRP QLAPAFTFGA KPKHGVTESV SERGSGRESL SPPQSSLSPI
560 570 580 590 600
VVNRSEGIGG AAATGLAGLA ARAHKRTGSE MSSVLQQQFA IQQEIEALQA
610 620 630 640 650
KQKALMQQDL AQQGDSPLAQ LNTAYAQKQT PSQNLSRHRR VQSSLPSASV
660 670 680 690 700
PVDFEREQDQ PRSMKSVGEM LPPPIPSGHG RRHSVNVLNK TAGSGMGFGL
710 720 730 740 750
ADDIPEGVVA PSGHRRSGSR SGLESGSWRL GASSGNAQSS QSQVADLAAA
760 770 780 790 800
QAQLQSLAQF RAAAGGGHSK MASFSFPNML PNLLAATTLQ APVGQSLWQQ
810 820 830 840 850
QQAFQMQLQQ TTQGPQRKSL FAPYLPQASL PPLLQAGKLV VGVLRVNKKN
860 870 880 890 900
RSDAYVATDV LDADIYICGS KDRNRALEGD IVAVELLDVD EVWSTKKDKE
910 920 930 940 950
EKKRKKEENA TYDLKPSTVK KLEKKKDDVE VEGQGLTLFD DEEVNDDTKP
960 970 980 990 1000
TYAGHVVAVV ERMPGQLFSG QLGVLRPSSA ATKEKQELER REREGDKARK
1010 1020 1030 1040 1050
EEPEARPKIV WFKPTDKRVP LIAIPTEQAP ADFIDNPDAY SNKLFVATIK
1060 1070 1080 1090 1100
RWPITSLHPF GTLVEELGAI GNSEVETSAL LKDCNFPTEE FSEMTMKCLP
1110 1120 1130 1140 1150
PMPWSVPERE YDVRTDLREE RVFTIDPPHS KDLDDALSFK DNKDGTFTVG
1160 1170 1180 1190 1200
VHIADVSFFV KTNTQLDREA RKRATSVYLV QRVVPMFPPL LSEDLCSLIP
1210 1220 1230 1240 1250
DYERLTFSAI FTVDEEGNVL QKKFAKTIVK SCAKLTYDDA LTVVKGGALP
1260 1270 1280 1290 1300
RSKTSGTHLA TDIERDIKSL HSIANKMRAR RIENGAMVVS SSKVSFEFDA
1310 1320 1330 1340 1350
QGRPVDCRTY QKGEESAIVE EFMLLTNQSA ARIIANALPE QALLRRHEAP
1360 1370 1380 1390 1400
SERRLESFVA RATKLGFDMD ATSAGTLQKS FDNVLDNDSA LCIDLLRKKV
1410 1420 1430 1440 1450
IQRARYFCAG MLDIAKYAHW GLNTPLYTHF TSPIRRYADV LVHRMVDACL
1460 1470 1480 1490 1500
TSPNPNEVKF LMDRDQVAKA AQQCNMKKQS AKLAEEQSVH LFLCILIDDL
1510 1520 1530 1540 1550
TEHYGPVVRE ARVTNVLETA FDVIIPEFGV EKRVHVDKMP VETAVYDEHR
1560 1570 1580 1590 1600
DILSLYWTTK DVISHLADTT EDRRLLKIKS LGEQPLPWFL NSMRSQPTLR

HSNLRGSAL
Length:1,609
Mass (Da):175,337
Last modified:November 13, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91C73C399F97491B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003827 Genomic DNA Translation: AGV14550.1

NCBI Reference Sequences

More...
RefSeqi
XP_012051195.1, XM_012195805.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AGV14550; AGV14550; CNAG_03345

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23886856

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003827 Genomic DNA Translation: AGV14550.1
RefSeqiXP_012051195.1, XM_012195805.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiT2BN03

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAGV14550; AGV14550; CNAG_03345
GeneIDi23886856

Organism-specific databases

EuPathDBiFungiDB:CNAG_03345

Family and domain databases

HAMAPiMF_03045 DIS3L2, 1 hit
InterProiView protein in InterPro
IPR041505 Dis3_CSD2
IPR028591 DIS3L2
IPR041093 Dis3l2_C
IPR012340 NA-bd_OB-fold
IPR001900 RNase_II/R
PfamiView protein in Pfam
PF17877 Dis3l2_C_term, 1 hit
PF17849 OB_Dis3, 1 hit
PF00773 RNB, 1 hit
SMARTiView protein in SMART
SM00955 RNB, 1 hit
SUPFAMiSSF50249 SSF50249, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2BN03_CRYNH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: T2BN03
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: July 31, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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