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Protein

Purine nucleoside phosphorylase

Gene
N/A
Organism
Crotalus horridus (Timber rattlesnake)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37PhosphateUniRule annotation1
Binding sitei68PhosphateUniRule annotation1
Binding sitei120Phosphate; via amide nitrogenUniRule annotation1
Binding sitei205Purine nucleosideUniRule annotation1
Binding sitei224PhosphateUniRule annotation1
Binding sitei247Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
OrganismiCrotalus horridus (Timber rattlesnake)Imported
Taxonomic identifieri35024 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 281PNP_UDP_1InterPro annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit

Sequencei

Sequence statusi: Complete.

T1E4L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANPREERFT YEDYKRTADW LLSKTKHRPR VAIICGSGLG GLADLLKDQV
60 70 80 90 100
VFEYAKIPNF PQSTVVGHAG KLVFGNLSGT PTVVMQGRFH MYEGYPLWKV
110 120 130 140 150
TFPVRIFHLI GVETLIVTNA AGGLNPAFKV GDIMVIRDHI NMPGFSGQNP
160 170 180 190 200
LIGPNDERFG VRFPAMSDAY NEDLRKLAVT VATEIGCSGC MREGVYCALG
210 220 230 240 250
GPNYETIAEC RLLQRLGVDA VGMSTVPEVI VARHCGLRVF GFSLITNKAI
260 270 280 290
LDYDTKEKAN HEEVLEASRQ SARTLEKLVS MMVQRIEGNN NLA
Length:293
Mass (Da):32,352
Last modified:October 16, 2013 - v1
Checksum:i58958F6F3BBEF0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAAZ01001950 mRNA Translation: JAA95993.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAAZ01001950 mRNA Translation: JAA95993.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00606

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT1E4L8_CROHD
AccessioniPrimary (citable) accession number: T1E4L8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: October 25, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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