Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pantothenate synthetase

Gene

panC

Organism
Sphingobium baderi LL03
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotationSAAS annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei153PantoateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi147 – 150ATPUniRule annotation4
Nucleotide bindingi184 – 187ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
ORF Names:L485_14315Imported
OrganismiSphingobium baderi LL03Imported
Taxonomic identifieri1114964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium
Proteomesi
  • UP000015524 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

T0HRA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLRDLPAL RAALLALRRD GKPVALVTTM GALHDGHMAL VEEARRHAGH
60 70 80 90 100
VAVSIFVNPK QFGPNEDLDA YPRREASDAH MLQEAGVDIL WAPTVEVMYP
110 120 130 140 150
AGFSTNISLS GVTEGLDGAA RPGHFDGVAT VVAKLFNQVQ PDVALFGEKD
160 170 180 190 200
YQQLAVIRQM VADLDLPIEI VGLPTQRAED GLALSSRNAY LTGEERKQAL
210 220 230 240 250
ALPRALGEAK RQMEKGASVE SALAKAIAML ASHGFDPIDY VTLCDAATLE
260 270 280
PMTVLDRPAR LLGAAKIGGT RLIDNIAVDP A
Length:281
Mass (Da):30,044
Last modified:October 16, 2013 - v1
Checksum:i49518EDDE6979EE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ATIB01000071 Genomic DNA Translation: EQB00094.1
RefSeqiWP_021245495.1, NZ_KQ130471.1

Genome annotation databases

PATRICifig|1114964.3.peg.2805

Similar proteinsi

Entry informationi

Entry nameiT0HRA8_9SPHN
AccessioniPrimary (citable) accession number: T0HRA8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health