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Entry version 24 (31 Jul 2019)
Sequence version 1 (16 Oct 2013)
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Protein
Submitted name:

Rhoptry metalloprotease toxolysin TLN1

Gene

TLN1

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseImported, Protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M16.021

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rhoptry metalloprotease toxolysin TLN1Imported (EC:3.4.24.56Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLN1Imported
ORF Names:TGME49_269885Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8G9G0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 227Peptidase_M16InterPro annotationAdd BLAST135
Domaini257 – 425Peptidase_M16_CInterPro annotationAdd BLAST169
Domaini445 – 834Peptidase_M16_MInterPro annotationAdd BLAST390

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 75DisorderedSequence analysisAdd BLAST21
Regioni961 – 1171DisorderedSequence analysisAdd BLAST211

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi961 – 1017PolarSequence analysisAdd BLAST57
Compositional biasi1026 – 1085PolarSequence analysisAdd BLAST60
Compositional biasi1114 – 1140PolarSequence analysisAdd BLAST27

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
IPR032632 Peptidase_M16_M

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
PF16187 Peptidase_M16_M, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63411 SSF63411, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8G9G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQGTTRPRV GLTGAVLLLV VWTVAILIDC SSGSRVLFDR RPILARLRRA
60 70 80 90 100
TSFVDSTSGQ NASPRPTKTD KIRKPRNDSR NYRYIELPNE LRALLVSDPE
110 120 130 140 150
CDEAAASMRV GVGSMSDPPK IPGLAHFTEH MLFQGSKRFP GTHDFFDFVH
160 170 180 190 200
NHGGYTNAFT SKFSTVFSFS IGPGFLEPGL DRLADLFSAP LLKSENLLKE
210 220 230 240 250
VNAVHSEYII DLTDDGRRKH HLIRQTAKGG PFSNFTVGNL ESLMERTKQQ
260 270 280 290 300
GIDPVKAMRE FHNKWYSSNL MTLAVVGRES LDVLESHVRK HFGNVPNGRV
310 320 330 340 350
TPPVFEECSE AFIPLDPNEL GTETLVVPEA DLHDATFVFY LPPQAKNWRS
360 370 380 390 400
KPLQFISEML EHEGPTSLSS KLKREGLITS LVTDYWSPEL CTVLQVNVRL
410 420 430 440 450
TEGGRSKESV YKIGHALFTF LRNLGVSRPE RWRVTEMAKI RQLGFAFADM
460 470 480 490 500
PDPYALTVRA VEGLNYYTPE EVIAGDRLIY HFDPDIIQQY VQKFLVPDNV
510 520 530 540 550
RLFIFDKKLA ADVDREEYWF KIKHGVEPIM DSAFKKWKEI TSAPANTVQS
560 570 580 590 600
MMRMEGMALP APNRFLPNNV AILPRPPGSG QGAEKSAFPE PLVFAGDHIC
610 620 630 640 650
ANKCAVFHKQ DTTFHSPKAV VELQIYYTGS HEDGVRERIL TALYVQSLRF
660 670 680 690 700
ALRERFADTH RAGMSLGLGS GVAVGSTTLP TVKRQRVLTL SAAGFSDKLD
710 720 730 740 750
YVLRAFAKSL AATEGASDEK PIPSPMELGV TMSHGVRHLM HSRVTAPSNV
760 770 780 790 800
LASVQSSRVY TTAVRLPGGG RAARRTLTHD QITTMHRKPA SMDVTLMRTP
810 820 830 840 850
VSSLGIRIVG GRAEREATSV VAGGGKPLLE KRFFRLAFDQ LRTDLRVATL
860 870 880 890 900
NRTPLAQAND AVLELIMHPH VPVHKMYAAL FEMEKNHPTL DAIFEEVADW
910 920 930 940 950
GVKLWNEAAV EGLVQGNITS ESATQLVGDV ISLLPLKNIV AANTIAKPTI
960 970 980 990 1000
SSFSSLRRAS SVAPQSSSKQ DSVPSSDMPT STETLSMPSS AESQTPESTD
1010 1020 1030 1040 1050
RASFPMESTT GPAPYSVELS TGRTPYPDDL PTSSTPYPDD LPTSSTPYPD
1060 1070 1080 1090 1100
DLPTSSTPYP DDLPTSSTPY PDDLPTSSTP YPDDLPTRST PAADDLPASS
1110 1120 1130 1140 1150
TPYPDDLPTS GTPYPDDLPT SSTPYPDDLP TSSTPYPDDL PTRSTPAADD
1160 1170 1180 1190 1200
LPTSRTPYPD DLPIRSTPSP IVLSAGRAPS VVVSPIERTS SPALLPTERT
1210 1220 1230 1240 1250
PLTERIAQAL RPVGEAAAVR RLLVLRRSSI HRMPYSPFQY SSTWFHPSSN
1260 1270 1280 1290 1300
SRRQMMLRMA LRRQLGALTR QAQPDTEGKP STVFVFRRLA PMPRRLNIEQ
1310 1320 1330 1340 1350
GPSFLQRQGE YAASGSAPHS DCTNGACAKG ACSGTGCQKT PVKPSGGPCK
1360 1370 1380 1390 1400
GDACTGSSCN SLECQRSSSS KSDHPCTGDE CPVPCRGPGC SAPASHPSPC
1410 1420 1430 1440 1450
TETECGKNSC PGCKQEEEKL VQLRSIRKNL NPNDKKNQAY LLIEVGALPN
1460 1470 1480 1490 1500
IHDRAVLYMV SRWMSQRFFN KLRTEQQLGY LTAMHSSRLE DRFYYRFFIT
1510 1520 1530 1540 1550
STYDPAEVAD RIVEFINAER SKIPTQEEFA TLKQAAIDVW KQKPKNIFEE
1560 1570 1580 1590 1600
FRKNRRQVVL GDRLFDINER MVAELERVTP EEIQSFKEKT MFNAPWLLME
1610 1620 1630 1640
VYSQREKPQM LPQANGASGE SKLDPWVDID PELLSNITVP DMESD
Length:1,645
Mass (Da):182,009
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA22F6C812701CD1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KE138831 Genomic DNA Translation: EPT28370.1

NCBI Reference Sequences

More...
RefSeqi
XP_018636597.1, XM_018781561.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_269885-t26_1; TGME49_269885-t26_1; TGME49_269885

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7894581

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_269885

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138831 Genomic DNA Translation: EPT28370.1
RefSeqiXP_018636597.1, XM_018781561.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiM16.021

PTM databases

SwissPalmiS8G9G0

Genome annotation databases

EnsemblProtistsiTGME49_269885-t26_1; TGME49_269885-t26_1; TGME49_269885
GeneIDi7894581
KEGGitgo:TGME49_269885

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
IPR032632 Peptidase_M16_M
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
PF16187 Peptidase_M16_M, 1 hit
SUPFAMiSSF63411 SSF63411, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8G9G0_TOXGM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8G9G0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: July 31, 2019
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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