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Entry version 37 (31 Jul 2019)
Sequence version 1 (16 Oct 2013)
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Protein

Clathrin heavy chain

Gene

TGME49_290950

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TGME49_290950Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
ToxoDB:TGME49_290950

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Coated pitUniRule annotation, Cytoplasmic vesicleUniRule annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8G8J0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati567 – 714CHCRPROSITE-ProRule annotationAdd BLAST148
Repeati716 – 858CHCRPROSITE-ProRule annotationAdd BLAST143
Repeati863 – 1004CHCRPROSITE-ProRule annotationAdd BLAST142
Repeati1011 – 1161CHCRPROSITE-ProRule annotationAdd BLAST151
Repeati1165 – 1308CHCRPROSITE-ProRule annotationAdd BLAST144
Repeati1313 – 1458CHCRPROSITE-ProRule annotationAdd BLAST146
Repeati1461 – 1604CHCRPROSITE-ProRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1654 – 1676DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1654 – 1670PolyampholyteSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin heavy chain family.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04646

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits
2.130.10.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR016025 Clathrin_H-chain_N
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637 Clathrin, 7 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002290 Clathrin_H_chain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00299 CLH, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236 CHCR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8G8J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQFPIQLH SVVNLADQGV SASSFRFGNV AMHGDKNLVV KDTETNELFI
60 70 80 90 100
FSLSVREVHE GRVSPSSPGF SFTKKPTQAE AALMHPSEKV VALRAKTEGS
110 120 130 140 150
AGHMIQVLNL ETKVRLGTAQ MNEPVVYWRW VAPTLLALVT DRAVYHWTVG
160 170 180 190 200
ENGETTAEPE KVCSREGRLA DAVQIISYAV DKDLKWCILT GISTQDGGKT
210 220 230 240 250
IDGSMQLYSM ELKKQQQLEG HAACFNNIVI DEAVGPQPVI CFTEKKRGSP
260 270 280 290 300
DFKLHIRDIY SSRDGGQTPL RLAVDLRMPE DAPTDFPLSI HISQKFGVVY
310 320 330 340 350
IVTKGGYLIL LDALTGTELF RHRILQDAVF LATDSPQTGG ILTVNKRGLV
360 370 380 390 400
CLCNINLQAL IPYINQALVY VPNRQQIATS LAKRYGLPGA EETLMQEFNQ
410 420 430 440 450
HFASGNFKTA ARIAATLKSG VLRTAQVIQQ FKSVPTQPGQ TSAILVYFST
460 470 480 490 500
LLEYDSLNAV ESLELVRPVA VQGRKDFVEK WLREGKLECT EELGDVVRTL
510 520 530 540 550
DAQLAVRVYR EAKAGAKVLQ TLTELGNFDE IIAFAKETKL EADYAGLLRN
560 570 580 590 600
LVNVHPENAV KFAQQLLSSE PPLADVTQVS EVLLQQHKYQ EFTSLMLDFL
610 620 630 640 650
KGNKPEQGPL QTRLLEVNLL HSPQVAETIF QMEMLTHFDR AKIAALCEKV
660 670 680 690 700
GLSQRALELY TDIADIKRVM LQSGGKISQE FTQQFFGNLP PDASLEILTD
710 720 730 740 750
MLRSSSQNLQ AVVAVAIKFH GQIGTTKLVE MFEKFSSYEG VFYFLGSILA
760 770 780 790 800
FSSDPEVHFK YIEAAAKLNH TQEVERVCRE SKCYEPQRVK EFLKQVKLPD
810 820 830 840 850
PRPLIYVCDL HGYVTELAEY LFKNSLLKYI EVYVSRVNSA NAPLVIGTLI
860 870 880 890 900
DQDAAEDFIR NLLQSVRGGC SAQQLVEEFE KRNRLRLLLQ WLEARVAEGN
910 920 930 940 950
QEPAVHNALA KIYIDTNRDA ESFLKTNAYY DSLVVGKYCE ERDPHLAFTA
960 970 980 990 1000
YKRAWGACDE QLVELTNKNG LFRLQARYLV ERQAPELWAY VLREENPHRR
1010 1020 1030 1040 1050
QAIDQVVSSA LPESSSADEV SAAVNAFINA QLPHELIELL EKIVLHNSDF
1060 1070 1080 1090 1100
SNNKNLQNLL ILTAMKADSS RIIDYVNRLH NYDGAAIAQV AMEYGLREEA
1110 1120 1130 1140 1150
FTIYKRFGLF GEAADTLLKS AEEGSEADLE RAVEFAQRCN EADVWRKLGR
1160 1170 1180 1190 1200
AQLRQKRVRD AIESFLKAGD GDVYKEVVEA AAAEDAYDAL VDFLLMARKK
1210 1220 1230 1240 1250
ITVKDQVIDS ELVYAYAKTD RLEEMDAFLS GTNTANVQAV GDRLFAEQRY
1260 1270 1280 1290 1300
KAAKLLYASL PNYAKLASCF VRLEDFAASV DAARKAKNPK TWKEVAFAAL
1310 1320 1330 1340 1350
SKGELKCAHA AALSLIVHPD HLDSLIERYE QLCLFKELIE LLEQGLQGER
1360 1370 1380 1390 1400
THVGLYTELG VLYATYESSK LMDYIRQHSG KVNIPRLIRA CERQSLWKEA
1410 1420 1430 1440 1450
VYLHMNYDEY EQAANCLIMH PAAWSHELFV QILQKVSNSD VFYRAISFYL
1460 1470 1480 1490 1500
EYHPLQLCLL LKSLDKKLDH SRVVQHVRKA GHLAVVEKYL RETQHLNITA
1510 1520 1530 1540 1550
VNEAVNELLV EGEDVDGLRE SILEYDNFDQ LALAQTLENH PRVEMRRLAA
1560 1570 1580 1590 1600
LLFKKNRKFK QAIELSKRDR QYQDAIDAAR DSGNTQLVGD LLRFFLADLE
1610 1620 1630 1640 1650
DPAGFAACLY TCYPLVKPDV ALELAWRHKC MDYCMPFLIQ VVREVTTRVD
1660 1670 1680 1690 1700
ALDKKEETRE KEEEKQKNAP NDYVPDYTMP PTGSPLLPGM GGLALMPPSY
1710 1720 1730
TPQSNAFPPT LGASGMMGSA PANLGQSFAP F
Length:1,731
Mass (Da):194,503
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3955778B2531A7A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138832 Genomic DNA Translation: EPT28055.1

NCBI Reference Sequences

More...
RefSeqi
XP_002368479.1, XM_002368438.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_290950-t26_1; TGME49_290950-t26_1; TGME49_290950

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7896454

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_290950

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138832 Genomic DNA Translation: EPT28055.1
RefSeqiXP_002368479.1, XM_002368438.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8G8J0

Genome annotation databases

EnsemblProtistsiTGME49_290950-t26_1; TGME49_290950-t26_1; TGME49_290950
GeneIDi7896454
KEGGitgo:TGME49_290950

Organism-specific databases

EuPathDBiToxoDB:TGME49_290950

Phylogenomic databases

KOiK04646

Family and domain databases

Gene3Di1.25.40.10, 4 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR016025 Clathrin_H-chain_N
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637 Clathrin, 7 hits
PIRSFiPIRSF002290 Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 7 hits
SUPFAMiSSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8G8J0_TOXGM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8G8J0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: July 31, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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