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Entry version 29 (31 Jul 2019)
Sequence version 1 (16 Oct 2013)
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Protein
Submitted name:

Inner membrane complex protein IMC2A

Gene

IMC2A

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inner membrane complex protein IMC2AImported (EC:3.1.3.2Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IMC2AImported
ORF Names:TGME49_228170Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
ToxoDB:TGME49_228170

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8G6H2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini391 – 641MetallophosInterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni977 – 1010DisorderedSequence analysisAdd BLAST34
Regioni1325 – 1346DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili951 – 971Sequence analysisAdd BLAST21
Coiled coili1013 – 1040Sequence analysisAdd BLAST28
Coiled coili1045 – 1079Sequence analysisAdd BLAST35
Coiled coili1126 – 1146Sequence analysisAdd BLAST21
Coiled coili1193 – 1220Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.21.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00149 Metallophos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8G6H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERRTRPDVS PRWQARRIHF VWLTALAVPI FLLFPSLSLL ESTSSAGCSG
60 70 80 90 100
IQCFASFPGV AAGSTHSREG ADPSPQETLM QPRRLSGIIK TLVLWDPVQR
110 120 130 140 150
LMPSLNLDSV VFVAGKHKAD RSAAFHTTMD DVMTLLLRWF NEKDKPNWLL
160 170 180 190 200
QGFVTEAALF REHVRYQDQM IHEQTQNQSE QQPTDPQAGM DKVLNIEVYT
210 220 230 240 250
YLAGAKRRVR DWICDGNTFM RTGEEGSHAF KQPFLTERDV GFLRGLPYNV
260 270 280 290 300
LRVARGVYSK RVPASVKRLQ EELFHRGIRT LNDLLLKTNL MDLFVLFDIM
310 320 330 340 350
DESFTQIDVL REFSNRWKKY RAEEVVPPLL PPGKWEGERS IEELMRDDHY
360 370 380 390 400
PSMKFPRCTM LKCVMQDTWS KNAVETITVE KKDTNSLKLL LIGNTGIGEY
410 420 430 440 450
KSRAERKGLW YKLKRFLWTN EFDQTVSALA KWHAEEKADA VLGLGDFLGI
460 470 480 490 500
PGPLSARDER FTKRWYDIFV KDAKLDIPWL MTLGEEEALV NPSASVRHHY
510 520 530 540 550
TGEHPNWYMP NDAYTATFSF STSMTMANGT IQHEAFNATV INVNTWNLFV
560 570 580 590 600
GNPIANNMQS MMDRLMWLSD QLYTAVNQTT NWLIIMGHLP LVSTGPQGEQ
610 620 630 640 650
GRLQYVDDLY KNGQPRGPEA VLIQMLLSHY QVDLYVSAHD HFMEYVALED
660 670 680 690 700
LSKNTTTAFI TSGAAVRLLD KDVGRGWIGR LRGALYPILC WSGRRILYAF
710 720 730 740 750
HPGGCHPERW DQNQAYRFFA PVNSQYKVNI VERVTKATGF AALRLTKDYL
760 770 780 790 800
VAEFIDSRSK KLAGRRASKR SNKDQRDIQF MDPVAEGRLR YDELEAARSA
810 820 830 840 850
FADANEERIS KEIQFARQCP ILAQRIKFYQ TEINDLVSKY DQIGKQKDAY
860 870 880 890 900
EVMDDNTIEI LLSEGVNVVS RIAQAVSEMN VLAGDYDKMV KKYRELIDLK
910 920 930 940 950
DTMPAADDPR YAQLFQLEKA YIDARKMRQQ TARELAVGRD GMQDREGEKD
960 970 980 990 1000
LERMILNMQV IRREIVAVEN DIKANPFVPS EEQPEEGKVD VNGAETPEGG
1010 1020 1030 1040 1050
DGKEPLPAIK YPDDSLEARI ERKREQLQKH ERSLSALKRA SPEDREKIKM
1060 1070 1080 1090 1100
RIVELERLIK GTQEELAAMQ QRLQRQQQAM RPSRVWQLLQ RRQDLETKLL
1110 1120 1130 1140 1150
QIKILVNQVE KLPEETRTSP DARAQVERLT AQRVNIEKDI RDISDELGTR
1160 1170 1180 1190 1200
EPTELEKQCL DKKASVWRAE LVLAQESLLS EKQRSIPVVR DAVHAAKRSI
1210 1220 1230 1240 1250
GGLRRELEEL TEKVKVELRE RDAAFDAGLE ASRVPPPEAE GRKVTPVPAP
1260 1270 1280 1290 1300
HVQANLETQG RSRADALMHE FNGGEDEIAV IDEAIRVSPL LSPEERAELE
1310 1320 1330 1340 1350
KLVGPVQDLP QKKADLEKRL AALKDQAEQE AQEANVDPEA KRAGSGSRRL
1360 1370 1380 1390 1400
FELFEPKKEP TPYKQLEPID LGPVDSCLQV PMLEYHVEIA LHPTMQKYIK
1410 1420 1430 1440 1450
DKCIFIFAQM AYQTQYRVIQ PVHLYLRSHK GLQTLLYRVP SVHVFRAWNQ
1460 1470 1480 1490
FFGSMHNTRF KSLLKTLKKG LKFVHETFKP VGARGEALEA S
Length:1,491
Mass (Da):170,816
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0FD9B3BFC66A115
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138836 Genomic DNA Translation: EPT27290.1

NCBI Reference Sequences

More...
RefSeqi
XP_002366439.1, XM_002366398.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_228170-t26_1; TGME49_228170-t26_1; TGME49_228170

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7896147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_228170

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138836 Genomic DNA Translation: EPT27290.1
RefSeqiXP_002366439.1, XM_002366398.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8G6H2

Genome annotation databases

EnsemblProtistsiTGME49_228170-t26_1; TGME49_228170-t26_1; TGME49_228170
GeneIDi7896147
KEGGitgo:TGME49_228170

Organism-specific databases

EuPathDBiToxoDB:TGME49_228170

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8G6H2_TOXGM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8G6H2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: July 31, 2019
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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