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Entry version 19 (02 Jun 2021)
Sequence version 1 (16 Oct 2013)
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Protein

C2 NT-type domain-containing protein

Gene

TGME49_224210

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C2 NT-type domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TGME49_224210Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGME49_224210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei74 – 97HelicalSequence analysisAdd BLAST24
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei149 – 171HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8G5J9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini189 – 438C2 NT-typeInterPro annotationAdd BLAST250

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni263 – 307DisorderedSequence analysisAdd BLAST45
Regioni348 – 372DisorderedSequence analysisAdd BLAST25
Regioni489 – 515DisorderedSequence analysisAdd BLAST27
Regioni539 – 671DisorderedSequence analysisAdd BLAST133
Regioni771 – 795DisorderedSequence analysisAdd BLAST25
Regioni1043 – 1065DisorderedSequence analysisAdd BLAST23
Regioni1167 – 1243DisorderedSequence analysisAdd BLAST77
Regioni1261 – 1356DisorderedSequence analysisAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili692 – 762Sequence analysisAdd BLAST71
Coiled coili797 – 863Sequence analysisAdd BLAST67
Coiled coili875 – 902Sequence analysisAdd BLAST28
Coiled coili910 – 937Sequence analysisAdd BLAST28
Coiled coili943 – 1006Sequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi263 – 279Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi498 – 515Polar residuesSequence analysisAdd BLAST18
Compositional biasi541 – 587Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi631 – 671Polar residuesSequence analysisAdd BLAST41
Compositional biasi771 – 785Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1167 – 1207Polar residuesSequence analysisAdd BLAST41
Compositional biasi1222 – 1236Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1306 – 1324Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1327 – 1343Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019448, NT-C2

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51840, C2_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8G5J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKTARSAET PTDDWRSSLR RFRRFKCREK KDLLSPDTFP FCVAQEAPRR
60 70 80 90 100
PSRSLKNRKK FSLHRERPSL RGHCFLAVAG CFAFSFAAAG GPALSVAVNS
110 120 130 140 150
DLSFCSRTRE KQIRFRLRFL APFFSPFSLL SPELLLFASP RCVWPFSDFF
160 170 180 190 200
SSLIPSAVLF LFAAFWLAVL FRSTLFARSS EMSRVLRGLK HIGQGSEKYR
210 220 230 240 250
FSLHVESVHI NTKAEKTFAT VEWLRGPKRC RGREVVVLSR GANTVRFSSQ
260 270 280 290 300
ELVLIATLFR SKGDGERGGE KEAPSKLKKF SLRRHSSVAS EAGVPPQAAN
310 320 330 340 350
AETSGRDDTE ASAACVYLPK ESKLQLVEVQ ESGRRSFRSF ASSRSQLGAS
360 370 380 390 400
ALASPPDAHP PEASGTSLFR RGASKPASAE SAKLVVGSNV LGECRLDLAQ
410 420 430 440 450
FVNGREGDAA DAPQRVTLPL DRCEDAQASI TFLVSWTLLG SAVDGEDDDA
460 470 480 490 500
VSLHSGLVSL ASEETFFKQP VSSSVASLLR VSPAPVHPPL GKETGVSLPA
510 520 530 540 550
HQTETGASEG RRTLSLSVSD ADAATRGLSP QEQLRNIFAK RGPESQREEG
560 570 580 590 600
DRGRAQQRKE QKGEEDGEKK DAEAKVEKNK ETEGKSDGTP SRPLGAASVT
610 620 630 640 650
EMLKARERSI AAQNMGEDRA REFLPTRSPV PSPASEVSTR GSSLPVAASP
660 670 680 690 700
AQEQRTEAEK PNVGGQSKTL SSLLSRRLRK DGVAAAACKE QATAEESKVL
710 720 730 740 750
QLLQRVSDLE RRNEEHQRLL VKAQQALEAK ESAERDEYEK KIRNLFSQIE
760 770 780 790 800
ELHSALANAQ EQQLTTVQQL EEERAKAKGG RGDKETTGKN AVSPTAYGTL
810 820 830 840 850
QEELNQLKAQ MKQAEQTHAE VELQYRMRQK QQQEKIDALQ ASLQNQQEEA
860 870 880 890 900
HAERAALQAL LREQQTTEES KDETVRVLTK ENRLLEEQRE LLRQQCEQTE
910 920 930 940 950
QKLCQSQDHL REETAAREKA ERELAHLRSA LGDTDEDPLR HQLLTLQQEV
960 970 980 990 1000
SELTATRDEL RRQKERDEQA HLQQLHQLQE QLRVTRDQQQ ERIHIVEQEK
1010 1020 1030 1040 1050
VTLRMQVLAL EHEISYCPKS PGERDFAANE QFAKKKMGTS LSSSLAPSAN
1060 1070 1080 1090 1100
LGGNADEAAA ARERREAEKR TAQLIEELEM DLVKTKIELA LAEQQRAEDL
1110 1120 1130 1140 1150
DLCKNKVASL KDTILSYAAV VSDLEVQVAD LKLQAQSRDF FSSTATARRL
1160 1170 1180 1190 1200
RPIRSLKSFF RAASSSRCSS SQQSPQQLPH QGALHASQDQ DARVSPSSLS
1210 1220 1230 1240 1250
GALSPLNSRL RSAPPLAEGE GTGRGEETRE RRASPLPSTY RKQSSHVVVF
1260 1270 1280 1290 1300
DADDLSFSST SLLQKRDRDS RGEGADKRGT GCPPLPVHAT KPPPRSESFR
1310 1320 1330 1340 1350
FRLRSSTQAC RRERSEEGKI SFSGKSRETD GPASSGESGS WTSGRRSREA

EMHACN
Length:1,356
Mass (Da):150,271
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DACB78068C64617
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138836 Genomic DNA Translation: EPT26930.1

NCBI Reference Sequences

More...
RefSeqi
XP_018635932.1, XM_018780038.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_224210-t26_1; TGME49_224210-t26_1; TGME49_224210

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7898222

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_224210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138836 Genomic DNA Translation: EPT26930.1
RefSeqiXP_018635932.1, XM_018780038.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8G5J9

Genome annotation databases

EnsemblProtistsiTGME49_224210-t26_1; TGME49_224210-t26_1; TGME49_224210
GeneIDi7898222
KEGGitgo:TGME49_224210

Organism-specific databases

VEuPathDBiToxoDB:TGME49_224210

Family and domain databases

InterProiView protein in InterPro
IPR019448, NT-C2
PROSITEiView protein in PROSITE
PS51840, C2_NT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8G5J9_TOXGM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8G5J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: June 2, 2021
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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