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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Streptococcus agalactiae FSL C1-494
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei599For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
ORF Names:SAG0024_06710Imported
OrganismiStreptococcus agalactiae FSL C1-494Imported
Taxonomic identifieri1154783 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000015146 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2InterPro annotationAdd BLAST217
Domaini284 – 423SISInterPro annotationAdd BLAST140
Domaini456 – 594SISInterPro annotationAdd BLAST139

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

S8FZW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGVVGN TNATDILIQG LEKLEYRGYD SAGIFVVGDN KSQLVKSVGR
60 70 80 90 100
IAELQAKVGD SVSGTTGIGH TRWATHGKPT EGNAHPHTSG SGRFVLVHNG
110 120 130 140 150
VIENYLQIKE IYLTKHNLKG ETDTEIAIHL VEHFVEEDNL SVLEAFKKAL
160 170 180 190 200
HIIEGSYAFA LIDSQDADTI YVAKNKSPLL IGLGNGYNMV CSDAMAMIRE
210 220 230 240 250
TSEYMEIHDK ELVIVKKDSV EVQDYDGNVI ERGSYTAELD LSDIGKGTYP
260 270 280 290 300
FYMLKEIDEQ PTVMRKLIST YANGSGDMNV DSDIIKSVQE ADRLYILAAG
310 320 330 340 350
TSYHAGFAAK TMIEKLTDTP VELGVSSEWG YNMPLLSKKP MFILLSQSGE
360 370 380 390 400
TADSRQVLVK ANEMGIPSLT ITNVPGSTLS REATYTMLIH AGPEIAVAST
410 420 430 440 450
KAYTAQVATL AFLAKAVGEA NGKAEAKDFD LVHELSIVAQ SIEATLSEKD
460 470 480 490 500
VISEKVGQLL ISTRNAFYIG RGNDYYVTME AALKLKEISY IQTEGFAAGE
510 520 530 540 550
LKHGTISLIE DNTPVIALIS ADSTIAAHTR GNIQEVVSRG ANALIIVEEG
560 570 580 590 600
LEREGDDIIV NKVHPFLSAI SMVIPTQLIA YYASLQRGLD VDKPRNLAKA

VTVE
Length:604
Mass (Da):65,503
Last modified:October 16, 2013 - v1
Checksum:iC671040055E9A3B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ALQD01000058 Genomic DNA Translation: EPT39613.1
RefSeqiWP_000334315.1, NZ_ALQD01000058.1

Genome annotation databases

EnsemblBacteriaiEPT39613; EPT39613; SAG0024_06710

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ALQD01000058 Genomic DNA Translation: EPT39613.1
RefSeqiWP_000334315.1, NZ_ALQD01000058.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEPT39613; EPT39613; SAG0024_06710

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS8FZW4_STRAG
AccessioniPrimary (citable) accession number: S8FZW4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: November 22, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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