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Entry version 30 (18 Sep 2019)
Sequence version 1 (16 Oct 2013)
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Protein
Submitted name:

DHHC zinc finger domain-containing protein

Gene

TGME49_213550

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DHHC zinc finger domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TGME49_213550Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 57HelicalSequence analysisAdd BLAST23
Transmembranei69 – 90HelicalSequence analysisAdd BLAST22
Transmembranei173 – 204HelicalSequence analysisAdd BLAST32
Transmembranei224 – 249HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8F5W6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 259DHHCInterPro annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 618DisorderedSequence analysisAdd BLAST312
Regioni636 – 773DisorderedSequence analysisAdd BLAST138
Regioni779 – 798DisorderedSequence analysisAdd BLAST20
Regioni946 – 965DisorderedSequence analysisAdd BLAST20
Regioni989 – 1019DisorderedSequence analysisAdd BLAST31
Regioni1041 – 1087DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi400 – 416PolarSequence analysisAdd BLAST17
Compositional biasi452 – 530PolyampholyteSequence analysisAdd BLAST79
Compositional biasi647 – 699PolarSequence analysisAdd BLAST53
Compositional biasi700 – 727PolyampholyteSequence analysisAdd BLAST28
Compositional biasi753 – 769PolyampholyteSequence analysisAdd BLAST17
Compositional biasi995 – 1009PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1057 – 1083PolyampholyteSequence analysisAdd BLAST27

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001594 Palmitoyltrfase_DHHC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01529 DHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8F5W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPALADPEH PRAYGANYVY CNGCGITGPD RRTALVSLAM ILIPSVVFMI
60 70 80 90 100
WTSPWFASHF GVGVPLTQAL LVLLTVYFFS VTACSDPGIL PRHRSPMNAF
110 120 130 140 150
DPLTGAYRAR QPPRYQDVVI NGNCIRLKFC TTCNIYRPPR SVHCAICDNC
160 170 180 190 200
VERFDHHCPW LGNCIGLRNY RTFIFFVIFC SLLSVFTFVS SAVKVAFVVV
210 220 230 240 250
WLRADGLNSD DVFQQLWGKA TESVLLLVYT FVLSWFVLAL FAYHGYLIAT
260 270 280 290 300
NQTTYEQIKS FFYEGNPWSK GLAGNLADVF CRPVRARYFS PIMPVLCFLE
310 320 330 340 350
EDDLGRSSSP LNELSGDSAR DTPSPLAREE SAHASGSADL DVPLSQRPFA
360 370 380 390 400
NKRSPKGEEG GQAEKPVSSV MGASSSGVVS DSAAVRDPRG GELASDGSEE
410 420 430 440 450
TAAQALTTSF PAPSCPTSLT EAEAPPDVSM PSGAGIADSG ALAQEAGSDQ
460 470 480 490 500
KLLQRLSRKR QSEAEKEAAA QLRQKADARK SGDRRRQIGG GGREKGGRGE
510 520 530 540 550
RDLGLSSGKK EDDDPVDGLE RRETRTPVEG ESRNRAGATE TLRTRPPTGH
560 570 580 590 600
LRKNAGFPEN KVESPRTPQQ RPTASDSRGI ERRAPQEAKS TSEPASGSTP
610 620 630 640 650
GLGMEHASAP RDREMPAFAG QRLMVTTAVM GRPADFEGKR ANAEGTQSVA
660 670 680 690 700
CEETPTMQAL SSRASSSALP ESHAFQTTPG ENPGRTPEGP SGDTTLHCTA
710 720 730 740 750
ATETDDDGER ERDGREEKER DGKIHKNRPS TALPAARVAC SSERALPPVE
760 770 780 790 800
RDAGSVRGKR CEAPQEEGQG ERRIYPVSSR PGRRVVPSPR RTDENHHDGD
810 820 830 840 850
YLVHFKSETS SRFASYCPRV EGNSAFLSPL PEAPDCAEGV AACPCAETVF
860 870 880 890 900
FSSGEPRGED EVNQVFCLNQ EEETMCSCFP SAAAPPQRGS TAGESSKGRI
910 920 930 940 950
RFFSSGSFSA FRLFSSCFVA VPTPWARNRG SGSSWSGAYR TRLPAHSQTA
960 970 980 990 1000
EISPASASHS TQSLSHFRSS SSRVLQAFSH GGRLPASAVG AALERHRSSA
1010 1020 1030 1040 1050
RRDPEEAEGK QGTCLPIKKT GPFAGGCAPG QFVCRLSGED GAAGGAEASQ
1060 1070 1080 1090 1100
NESSRGTRNT ARRETAKGDE QAAWEEENEG RTGGDRSVLT YAAPQGCVSG
1110 1120 1130 1140 1150
PLSPRRRQGH EDLPSQSLNV SLEDHKAAGN CPSAPGRDTL PCGPARGIEA
1160 1170 1180 1190 1200
ESMLNTGLGE AVDGDCDDAE RDDLNACASR SRSVAGKACR CLPAGEWRGA
1210 1220 1230 1240 1250
ASRESRRPHV SCAFFSDTHD AANCDLETGR LHGEPGGSAD ATGVAHTERA
1260 1270 1280 1290 1300
SSCLGGKRMR DLVLRCGAIA CVLPDDEDED IRGGTAQQVQ ENMTDSYSHI
1310 1320 1330 1340 1350
LREAPSFRSS ARVVISQRWS DGAVALGEKR EYAMYERAKH QGYNSGELFS
1360
SGLLGSAAFE QE
Length:1,362
Mass (Da):146,326
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9C8F80F5BB76A68
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138823 Genomic DNA Translation: EPT31236.1

NCBI Reference Sequences

More...
RefSeqi
XP_018637893.1, XM_018779609.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_213550-t26_1; TGME49_213550-t26_1; TGME49_213550

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7898924

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_213550

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138823 Genomic DNA Translation: EPT31236.1
RefSeqiXP_018637893.1, XM_018779609.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8F5W6

Genome annotation databases

EnsemblProtistsiTGME49_213550-t26_1; TGME49_213550-t26_1; TGME49_213550
GeneIDi7898924
KEGGitgo:TGME49_213550

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8F5W6_TOXGM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8F5W6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: September 18, 2019
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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