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Entry version 19 (31 Jul 2019)
Sequence version 1 (16 Oct 2013)
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Protein
Submitted name:

Rhoptry neck protein RON8

Gene

RON8

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rhoptry neck protein RON8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RON8Imported
ORF Names:TGME49_306060Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 30HelicalSequence analysisAdd BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8F1T4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 56DisorderedSequence analysisAdd BLAST22
Regioni79 – 114DisorderedSequence analysisAdd BLAST36
Regioni2696 – 2718DisorderedSequence analysisAdd BLAST23

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8F1T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVATTLHSLP SRYLYTLLMS FLFVCGALAL HESPDGLPEA PDRPQNAESG
60 70 80 90 100
DGPPTLVLTL DPEYAGKSEE FAFTAEYFPP TESSKNEDGA QQSFVETPNR
110 120 130 140 150
RLPGTFDPMS SSDVRSEVQL RVTTQQMERG LLAEIVVLQE GQMVSGFRAS
160 170 180 190 200
LQTKEQAALL HRLADLTNDP NIHFRVEWRG RGDGTGGLYI RTAVHLLATA
210 220 230 240 250
YKPSVHFKLN LHQTGARGAR ETIKLLSSVP IDDLNAPGVD IGTLKQLIVD
260 270 280 290 300
HAEPENILTG PGSFSIKRMF KESDPKNANT QEATLVPWLL RLLDLASPVT
310 320 330 340 350
IVGDLTRNRE FSTVLPQGPA NWNDLLLLYT GMGDAANRGQ NAPDFAQREP
360 370 380 390 400
GYRPGSIFLS PDGFRGAAHL GDHQPDRLKQ FWRQGGETGL NPGDIEHYYS
410 420 430 440 450
PLFGRSYDTS NNPLLILDMY GNPVYSEGGV PKFIVGPGEN DLTKLPDHVS
460 470 480 490 500
GMVLPSVSAR FLFPDKRSFT EFINPARPWN DISKGWKALM AKHKMKFNYR
510 520 530 540 550
EPGLVGVSVN GNWYGLTSEF IQTYPTLLHL LGSLAQSTPG FSLEDVTLHF
560 570 580 590 600
DDKLPPKLPT LFVLDDAHDR QIPWCAFEFV IPLSPRGTVN IKSLLAKGKS
610 620 630 640 650
AAESPKGCNF REKGFHFTTV HRWGFVESRN PLSIQWHGVL DYTGSKQECA
660 670 680 690 700
LLGNVLKDAH LAGRQIAVSF HAEHKATVIP VIETFGPDGE LLKSKPQKPV
710 720 730 740 750
TATVQFGDDL PGLLYDFHKP FQKKKVPTVV YPFLQGQGQG SRDALNGGVL
760 770 780 790 800
GEEYYHRPRK TKITMRPEIP ILNTHDTFVD GSGPHPNVPH FVIPLTAGPQ
810 820 830 840 850
QHLAPLKALR QWLRKEYPGS QLPFKLDRMS DEDLLGIADH LVFRFPDGTE
860 870 880 890 900
ATLRSIFGPE VFSPNWATMN PDAYQKLMDV LTRPKKVYLA KNFRIVVTDV
910 920 930 940 950
DGQQIPFDIQ IEPGDTWAKT LDDFFKAHPN LKPANVKLVL YDDKDTALRQ
960 970 980 990 1000
FDINLDMYAS PYTEAVDQQH MKGLQITLET PAPIVSCYQA DPARPGQCLA
1010 1020 1030 1040 1050
VDMKRIFCGR VNPAKMVSRA WNEECTAAWI ARADLGEVED RYLMGPDDVR
1060 1070 1080 1090 1100
ARSIRDLLTS AKNALKQRNP EKAKHLNIPV ADVTESEELN RKMRERTELA
1110 1120 1130 1140 1150
MKSGKTLEDL DRLRHLKFEI RTLQRQGELQ WAKLVGATIT TTEKGKPAER
1160 1170 1180 1190 1200
HIRLDPKKFF LNDKLWKVFK ELAAQVPGLK FENVFNFSFE VMNKEAREQW
1210 1220 1230 1240 1250
KKEQTTVTKE AKKQMRSQKT VVDVIFVGPD GSALFRDIGV ELRQLSDEAL
1260 1270 1280 1290 1300
GRLSKGDKRG LINQLAKRYD IPRQYFIRRG GFPSAAVNGT KWVITAMLGL
1310 1320 1330 1340 1350
VGGAGKKGLA SLLKDPHAFV THLQSAGGFS PTDTVKLVFD NGSVLDVPLS
1360 1370 1380 1390 1400
QLPDQDLGSL AEIYFPWKKT AGQAQEEKKK AVESKVAEGS GIMRKLEVTV
1410 1420 1430 1440 1450
MQPSLWPEVF GAWLSDLHEM DLFDDGPILL QVRPEGAQKG QVIRCSVKTL
1460 1470 1480 1490 1500
GELYQALNKP EIIRSKCPGM ADLKKPFTFE LSIRTPAEQY YKLYNRSRSP
1510 1520 1530 1540 1550
EDQRRTAAVL LKLKDHIRNL PDDGQVIFEY RKIKRTLTPQ ELQQLKALIE
1560 1570 1580 1590 1600
GLQPNENTDD VLTKILRLLG ISDQDIAKSG RLRFGIKQAP TSSEQQMLRE
1610 1620 1630 1640 1650
GSITAVVEDF QGGRRKATVR ISIPEEEPLR LGASAQNYQV HMSLFSKNAQ
1660 1670 1680 1690 1700
HLNTPCGSKS GAEVAKATWG QLCRWCNLKL ADLPGLGHPT LYIRIISNEK
1710 1720 1730 1740 1750
TQTVRGGQPV TTNVDGHPVV YDIRMPGDPR SASGMPKSVF WNLVERPGSN
1760 1770 1780 1790 1800
ELGPVWHQSI PKADGGLRKD YSYFDPNPGA WDPTLFGPSS GTFPQNTRAG
1810 1820 1830 1840 1850
IDIVTNPEAM ETGDAYAPPI RFGFGFRNWN DRDAVKPQFN NMVSGIAPQE
1860 1870 1880 1890 1900
RDLYKVYIQI PKGDGNYYPC SGVDINLFMQ LTKEQIARAC GIHPSLLEAP
1910 1920 1930 1940 1950
FGVYLLKETP TYARAQPSFP LFFVDGEGQE HPSLGHWTDA PAKFFSPHLR
1960 1970 1980 1990 2000
GASPNSLIQL EFAPGVTCNL TQQELMSLHT WEALLKRCNI DAGKERPATI
2010 2020 2030 2040 2050
TTRIVPMFST PNVTVKVPNE LLQPLLRQHR GISPDQLFRQ KPLEEVVALL
2060 2070 2080 2090 2100
LSNAHLGLYH VGLKYIDGTD QPYSECPEHL RQLPPSQIPG LQHIYIVPAS
2110 2120 2130 2140 2150
EGEGDFPGVF RGGTLGDMMK GMNLSPQTTY GDFVRTVKKK INSPEGLTIP
2160 2170 2180 2190 2200
GVRQHVGGSG RPAQQIIDFD FAGPESPPGA AGKPGWEATW RPATVGAFPD
2210 2220 2230 2240 2250
NMPIGDIDRE MHHPFLVFTT GHPPKYDLNG LAAYGGQPFR EETTHLDASL
2260 2270 2280 2290 2300
RNLVEWMKDS LGISDPNGIL AEIVIDTIRC PFPLSAAQLI SATIGHLLHH
2310 2320 2330 2340 2350
CQVNDLEMSH SIYVTPTPVP GYTATPKRNG PQIVINGHNY GAPGTAPRDF
2360 2370 2380 2390 2400
GQLFNLPGRP GARPLNQDLE VSFSPLPGKP PVRGVLPGDV LPLLQSISDK
2410 2420 2430 2440 2450
HGQPGVAVVL NFLRQLHALA ELPPGATLNI DTKLIPSQSP QQLYAPDQVP
2460 2470 2480 2490 2500
QPGPWIAGPT GGGRFPGGGV VVNESGGRRG PGGSAAVKFM PSTLRLPLLR
2510 2520 2530 2540 2550
QPSVELPRNS MLRGSIGGVG GLPRTEFVVP ILPSQKSMPI EQVLKFFGIA
2560 2570 2580 2590 2600
PAAVQTLDVQ EKPEQGAILI ESGTVTFVPL KGPTFTVSMK KINATDKNTL
2610 2620 2630 2640 2650
ATLLKAAGRS IIDLVGASDG TQPLVLKIVV DHGAVSPTKV TTPVGTPSHA
2660 2670 2680 2690 2700
RSAMEGLTIW NLLPPLIDVH SVKTITIRVQ AAKAFQQAAK AAAAAEGTEG
2710 2720 2730 2740 2750
DSAGEPLSRP KNVEPAVRTK FKNKIPELPA AFKPRQRTVS EINGAPNPKL
2760 2770 2780 2790 2800
VIFVEQDGQK TIRFTFPSRV NDVVIGQSTV SVVLDALLPN PGTWHRTFWG
2810 2820 2830 2840 2850
ALSPDGTSCK PTMEFQYPHW LQTKMAELPV PNHSSCLLIR EVSLNIKQRP
2860 2870 2880 2890 2900
NFFIKPYIFH SPLVIFALQG KQRIPIFEEQ VDPAVTSQPL TALLEQLGIP
2910 2920 2930 2940 2950
KTQLDTILQC SSTNIDAPGE CPSDSSTTVD PETVIPDAVA TQSAFLVVTG
2960 2970 2980
KQKQAPGSFL QVLWRRQRRR NSIQKRITSH
Length:2,980
Mass (Da):328,900
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54AD8A0FA0C27AC8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138834 Genomic DNA Translation: EPT27438.1

NCBI Reference Sequences

More...
RefSeqi
XP_018636158.1, XM_018782468.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_306060-t26_1; TGME49_306060-t26_1; TGME49_306060

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7901329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_306060

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138834 Genomic DNA Translation: EPT27438.1
RefSeqiXP_018636158.1, XM_018782468.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8F1T4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiTGME49_306060-t26_1; TGME49_306060-t26_1; TGME49_306060
GeneIDi7901329
KEGGitgo:TGME49_306060

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8F1T4_TOXGM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8F1T4
Secondary accession number(s): A0A0N5EAK3, V5AZ22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: July 31, 2019
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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