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Entry version 47 (29 Sep 2021)
Sequence version 1 (16 Oct 2013)
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Protein
Submitted name:

DnaK family protein

Gene

TGME49_226830

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DnaK family proteinImported (EC:3.6.1.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TGME49_226830Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGME49_226830

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8F106

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni573 – 595DisorderedSequence analysisAdd BLAST23
Regioni635 – 655DisorderedSequence analysisAdd BLAST21
Regioni873 – 938DisorderedSequence analysisAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili680 – 717Sequence analysisAdd BLAST38
Coiled coili769 – 789Sequence analysisAdd BLAST21
Coiled coili793 – 813Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi876 – 891Polar residuesSequence analysisAdd BLAST16
Compositional biasi892 – 938Basic and acidic residuesSequence analysisAdd BLAST47

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005965_5_0_1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
S8F106

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043129, ATPase_NBD
IPR018181, Heat_shock_70_CS
IPR029048, HSP70_C_sf
IPR013126, Hsp_70_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00012, HSP70, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100934, SSF100934, 1 hit
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01036, HSP70_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8F106-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPAFEGVS PCVGGHRRVS PSGSSVRSLS HSSRLGCFFF AFCFLSVSLF
60 70 80 90 100
SPLGAKAQVV GLDLGSEFVK VALVAAGRPI EILLNPASKR KTNNAVSFAD
110 120 130 140 150
EEKRELGDEG AAQAAKKPDR VFLHPNLLLG VNATDFGLVD VTADPDSAFL
160 170 180 190 200
PLALKEKLLP SGYPHDYYPY RLFMDRRRHS VAVLAKDGVY LPAELLTASM
210 220 230 240 250
LAFVKKLATQ AAGVDNEKTL GCVISVPCRY TQRQRQALRD AVEIAGMHAV
260 270 280 290 300
AFHHHSVTAA VQHALDLPTN TTATKLFYDV GSSTIDVGVV RFAPVQLPSK
310 320 330 340 350
KEVLQVQLLA CESMSGAGGH HVDLAIAEKM RGAFERRHGA GKSLLGVPRA
360 370 380 390 400
LKKLVKQAVM AKHVLSANKQ TQFRVEGLHN DVDFHEPFER MHLEALLEEK
410 420 430 440 450
GMLAKLKASL DATLSHAGLD LNDVDQVELL GGASRVPRVQ QELGALMGAK
460 470 480 490 500
DVGTHLNGDE AMATGAAFIA ANSTATFRVK QLLLQDITPY EYLVKIDAVA
510 520 530 540 550
EEDDPDAGVR RGDRVKKTKV LVGRHARFAQ GSRTVSLRTT QDFQVELFED
560 570 580 590 600
DASLLKLAVT GVAEAAKKLE EEAQKKAEAE SKTEKNGEVE SETPERRLPK
610 620 630 640 650
ANLVFKVDGA GVLSFDRAYL TQDYFVYVPL PSTTTKATTT KESEGEETST
660 670 680 690 700
TTPAPAAKFK RLTKQVSDAL AVEETQTLPL PLTSEERNAL RKQLQEMEAA
710 720 730 740 750
DLRVHKLAEA MNRLEASIYA ARGLLAEETV ERVSLPETRE ELRKQLEADE
760 770 780 790 800
EWIYDSAKAE GIEAVKKKLV ALESVVEPMK KRAEELEARP KAIEKMEKAL
810 820 830 840 850
VDLVSRLEQI ATKRPWVSEE KLASVRAFGQ DVDAWWREKL ASQQSKLDTE
860 870 880 890 900
DPVFTKAEVL AKVKELGAAV KALENIPRPT TTTTTSPGEG KEPGEQKQEE
910 920 930
KTEEKKQEEK NEEKKEEEKN EEKKEEKVEE EHKNREEL
Length:938
Mass (Da):103,193
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6631B8B22550997
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138836 Genomic DNA Translation: EPT27178.1

NCBI Reference Sequences

More...
RefSeqi
XP_018636045.1, XM_018780151.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_226830-t26_1; TGME49_226830-t26_1-p1-CDS1; TGME49_226830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7895422

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_226830

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138836 Genomic DNA Translation: EPT27178.1
RefSeqiXP_018636045.1, XM_018780151.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8F106

Genome annotation databases

EnsemblProtistsiTGME49_226830-t26_1; TGME49_226830-t26_1-p1-CDS1; TGME49_226830
GeneIDi7895422
KEGGitgo:TGME49_226830

Organism-specific databases

VEuPathDBiToxoDB:TGME49_226830

Phylogenomic databases

HOGENOMiCLU_005965_5_0_1
PhylomeDBiS8F106

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
InterProiView protein in InterPro
IPR043129, ATPase_NBD
IPR018181, Heat_shock_70_CS
IPR029048, HSP70_C_sf
IPR013126, Hsp_70_fam
PfamiView protein in Pfam
PF00012, HSP70, 3 hits
SUPFAMiSSF100934, SSF100934, 1 hit
SSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS01036, HSP70_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8F106_TOXGM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8F106
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: September 29, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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