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Entry version 39 (02 Jun 2021)
Sequence version 1 (16 Oct 2013)
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Protein
Submitted name:

Ku70/Ku80 beta-barrel domain-containing protein

Gene

TGME49_312510

Organism
Toxoplasma gondii (strain ATCC 50611 / Me49)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, HelicaseARBA annotation, Hydrolase
Biological processDNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ku70/Ku80 beta-barrel domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TGME49_312510Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50611 / Me49)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri508771 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001529 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGME49_312510

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S8EUF7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini434 – 576KuInterPro annotationAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 77DisorderedSequence analysisAdd BLAST33
Regioni347 – 379DisorderedSequence analysisAdd BLAST33
Regioni397 – 434DisorderedSequence analysisAdd BLAST38
Regioni550 – 578DisorderedSequence analysisAdd BLAST29
Regioni625 – 658DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili891 – 921Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi350 – 379Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi397 – 414Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi637 – 658Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_282380_0_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.240, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR036494, Ku_C_sf
IPR014893, Ku_PK_bind
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02735, Ku, 1 hit
PF08785, Ku_PK_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00559, Ku78, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF101420, SSF101420, 2 hits
SSF53300, SSF53300, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S8EUF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPGQSFKR VIVLLLDCGA TMQQTLRGDF SDALVAQTEA LSSSFASSGG
60 70 80 90 100
ASSPSPLSKK ADSTPSQVPL SPDSVPSISA ADRSADLSSF HAMKRAARAY
110 120 130 140 150
VQRLAATSAK VDVGVVCFGS CRTDNPLAPV EGDIQPGDTG DAEEGYKHVE
160 170 180 190 200
VSLRPESASW KLVQELEKVK NSANRSDAID GLVVAVDMVE KTYGPKLSQN
210 220 230 240 250
NVSFLVFSDC QSSPATPEDI PAVRDRLEVL GIRVHFIIVD GSVPTHPGIW
260 270 280 290 300
RPGDPSARLN QHFVSPLRPA LASLSLVAST LIPLRSFLAS PFMTAFYPPP
310 320 330 340 350
KRLSTKCRVN LEVSKAFLIP VYVFVRTRKE PVPTLRKRVF VGVSRPATRR
360 370 380 390 400
RTDSVPREDT PGDAFGAEKT RNDQGEHDED WRDLKVERFY FRANDPERTP
410 420 430 440 450
VKLGEPDTRQ RDGTSIFGRP DGSSEDERAP GAGGDAGVHI QRLYAYRYGK
460 470 480 490 500
QLVAVSGVEQ QAFKQQTTAG LVVLGVTRRD SIQRWWNLGP PEYVTCALNN
510 520 530 540 550
RPSLVALRSL VLALQRLDSV LLCSFVWRGG YPAKLVALLP HVGGGNREKR
560 570 580 590 600
KAWQATASLK ESDDVKREEE TNQKEAGDED KTYGLHLIYL PVAEDMLELR
610 620 630 640 650
LPSLPSVTPR QLRAVETLVE SLTLPGSPQV SVKSGEKGGR ASEKDEGDRE
660 670 680 690 700
AEKKPIDGEW EEVEAQRKAL QAPASSPAGW QTNAPLEIAV DPSTRVHSPS
710 720 730 740 750
PPCSSAAFPS FLPDSISSFA TKSESLSLHK IHNPTLQRYY QLLVYRHYNP
760 770 780 790 800
ASPPVALGEE GSETQAQTTW REAEESHQHR LHHMWARGSP VERLFTVRTP
810 820 830 840 850
GCLDSEQPDA SVEQTKEAGQ RETQVDAALK AAFPQATSLE AQTAGRRQRE
860 870 880 890 900
VQQKLLFGEV VRKQKELVVR DVKVSGEWTE PHFDTPGEEP RMTAEARREE
910 920 930 940 950
TEKLERAIEE EERQKKLEAL KALHVHSVNP VRDFQRLLEV KETDLTEKAI
960 970 980 990 1000
QEMTEMIFKF LRAAGPPQGA LERPTGAGRG GETSGLQNFR RQQHLGKALV
1010 1020 1030 1040 1050
CVEALREGCR RELEGEKFNE FLAEVKAEQC RADAAADDSF RTFWNLLKSR
1060 1070 1080 1090 1100
KIGLITHAED PRVDLEPAQS LRIYEDESVQ ELSTQTAMTA ARPLDPHDVD

DLLDLVE
Length:1,107
Mass (Da):122,366
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7E9141DD4E26981
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE138837 Genomic DNA Translation: EPT26002.1

NCBI Reference Sequences

More...
RefSeqi
XP_002364473.1, XM_002364432.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_312510-t26_1; TGME49_312510-t26_1; TGME49_312510

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7900417

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tgo:TGME49_312510

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE138837 Genomic DNA Translation: EPT26002.1
RefSeqiXP_002364473.1, XM_002364432.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiS8EUF7

Genome annotation databases

EnsemblProtistsiTGME49_312510-t26_1; TGME49_312510-t26_1; TGME49_312510
GeneIDi7900417
KEGGitgo:TGME49_312510

Organism-specific databases

VEuPathDBiToxoDB:TGME49_312510

Phylogenomic databases

HOGENOMiCLU_282380_0_0_1

Family and domain databases

Gene3Di1.25.40.240, 1 hit
InterProiView protein in InterPro
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR036494, Ku_C_sf
IPR014893, Ku_PK_bind
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF02735, Ku, 1 hit
PF08785, Ku_PK_bind, 1 hit
SMARTiView protein in SMART
SM00559, Ku78, 1 hit
SUPFAMiSSF100939, SSF100939, 1 hit
SSF101420, SSF101420, 2 hits
SSF53300, SSF53300, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS8EUF7_TOXGM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S8EUF7
Secondary accession number(s): V4ZSF2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: June 2, 2021
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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