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Protein

Pyruvate carboxylase

Gene

BN860_13168g

Organism
Zygosaccharomyces bailii (strain CLIB 213 / ATCC 58445 / CBS 680 / CCRC 21525 / NBRC 1098 / NCYC 1416 / NRRL Y-2227)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

Catalytic activityi

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

Cofactori

biotinUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136ATPUniRule annotation1
Binding sitei220ATPUniRule annotation1
Binding sitei255ATPUniRule annotation1
Active sitei312UniRule annotation1
Metal bindingi566Divalent metal cationUniRule annotation1
Binding sitei638SubstrateUniRule annotation1
Metal bindingi734Divalent metal cation; via carbamate groupUniRule annotation1
Metal bindingi764Divalent metal cationUniRule annotation1
Metal bindingi766Divalent metal cationUniRule annotation1
Binding sitei898SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, BiotinUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
Gene namesi
ORF Names:BN860_13168gImported
OrganismiZygosaccharomyces bailii (strain CLIB 213 / ATCC 58445 / CBS 680 / CCRC 21525 / NBRC 1098 / NCYC 1416 / NRRL Y-2227)Imported
Taxonomic identifieri1333698 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
Proteomesi
  • UP000019375 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 470Biotin carboxylationInterPro annotationAdd BLAST453
Domaini140 – 337ATP-graspInterPro annotationAdd BLAST198
Domaini557 – 824Pyruvate carboxyltransferaseInterPro annotationAdd BLAST268
Domaini1094 – 1169Lipoyl-bindingInterPro annotationAdd BLAST76

Phylogenomic databases

PhylomeDBiS6ENY9

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

S6ENY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKKFSGLR DNFSLLGERN KILVANRGEI PIRIFRSAHE LSMRSVAVYS
60 70 80 90 100
HEDRLSMHRL KADEAYVIGE EGKYTPVGAY LAIDEIISIA KKHGVDFIHP
110 120 130 140 150
GYGFLSENSE FADKVAKSGI TWIGPPADVI DAVGDKVSAR NLAAKADVAT
160 170 180 190 200
VPGTPGPIES AEEALEFTKK YGFPVIIKAA FGGGGRGMRV VREGDDVADA
210 220 230 240 250
FQRASSEART AFGNGTCFME RFLVKPKHIE VQILADNYGN VVHLFERDCS
260 270 280 290 300
VQRRHQKVVE LAPAKTLPIE VRNAILTDAV KLAKVAGYRN AGTAEFLVDN
310 320 330 340 350
QNRHYFIEIN PRIQVEHTIT EEITGIDIVA AQIQIAAGAS LEQLGLLQDR
360 370 380 390 400
ITTRGFAIQC RITTEDPSKN FQPDTGRIDV YRSSGGNGVR LDGGNTYAGA
410 420 430 440 450
VVSPHYDSML VKCSCSGSTY EIVRRKMIRA LVEFRIRGVK TNIPFLLTLL
460 470 480 490 500
THPTFISGEF WTTFIDDTPQ LFQMISSQNR AQKLLHYLAD LAVNGSSIKG
510 520 530 540 550
QIGVPKLKKH PDVPHLHNSS GEIIDVVSTP PPSGWRQVLL EHGPDEFAKR
560 570 580 590 600
VRKFNGCLIM DTTWRDAHQS LLATRVRTYD LAAIAPTTAH ALAGAFSLEC
610 620 630 640 650
WGGATFDVAM RFLHEDPWER LRILRKLVPN IPFQMLLRGA NGVAYSSLPD
660 670 680 690 700
NAIDHFVKQA KENGVDIFRV FDSLNDLEQL KVGVDAVKKA GGVVEATVCY
710 720 730 740 750
SGDMLQPGKK YDLDYYLEVT EKIVKMGTHF LGIKDMAGTM KPAAAKLLVG
760 770 780 790 800
SIRAKYPDLP IHIHTHDSAG TGVASMAACA VAGADVVDVA VNSMSGLTSQ
810 820 830 840 850
PCMNALLASL EGEIDTGVNA THARELDAYW AEMRLLYSCF EADLKGPDPE
860 870 880 890 900
VYEHEIPGGQ LTNLLFQAQQ LGLGEKWAET KRAYRQANYL LGDLVKVTPT
910 920 930 940 950
SKVVGDLAQF MVSNKLTPDD VKRLASSLDF PDSVMDFFEG LIGQPYGGFP
960 970 980 990 1000
EPLRTDVLRN KRRKLTCRPG LELAPFDLEA VREDLQDKFG DTDECDVASY
1010 1020 1030 1040 1050
NMYPKVYEDF QKIKEKYGDL SVLPTKNFLS PPEIGEEIEV TIEQGKTLII
1060 1070 1080 1090 1100
KHQAVGDLNK ETGLREVYFE LNGELRKIHV VDRSQKVEIK SKPKSDGHDP
1110 1120 1130 1140 1150
LQIGAPMAGV IVEVKVHKGS LVKKGQPVAV LSAMKMEMVI SAQTDGQVKE
1160 1170
VFVSDGENVD ASDLIVTLED VAPAKET
Length:1,177
Mass (Da):129,451
Last modified:October 16, 2013 - v1
Checksum:i496FC85D286E5D6A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S6ELQ0S6ELQ0_ZYGB2
BN860_13168g1_1
BN860_13168g
253Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG316455 Genomic DNA Translation: CDF88563.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG316455 Genomic DNA Translation: CDF88563.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

PhylomeDBiS6ENY9

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS6ENY9_ZYGB2
AccessioniPrimary (citable) accession number: S6ENY9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: April 25, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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