Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 31 (29 Sep 2021)
Sequence version 1 (16 Oct 2013)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Transient receptor potential melastatin 5

Gene

trpm5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelARBA annotation, ReceptorImported
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transient receptor potential melastatin 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpm5Imported
Synonyms:TRPM5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060503-736, trpm5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei712 – 735HelicalSequence analysisAdd BLAST24
Transmembranei860 – 881HelicalSequence analysisAdd BLAST22
Transmembranei941 – 966HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
S5UH55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 254LSDAT_eukInterPro annotationAdd BLAST224
Domaini727 – 980Ion_transInterPro annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1122 – 1165DisorderedSequence analysisAdd BLAST44

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSENPWR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR002153, TRPC_channel
IPR029577, TRPM5
IPR041491, TRPM_SLOG

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF5, PTHR13800:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01097, TRNSRECEPTRP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S5UH55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEKSSERFD KQMAGRLGDI DFTGVSRTRG KFVRVTSSTD PAEIYQILTK
60 70 80 90 100
QWGLAPPHLV VALMGGDEVA QLKPWLRDTL RKGLVKAAQS TGAWILTSGL
110 120 130 140 150
RFGITKNLGQ AVRDHSLAST SPKVRVVAIG IAPWNMIQNR DLLLSAKPDH
160 170 180 190 200
PATYPTEDLP YGAVYSLDCN HSHFILVDED PKRPGATGEM RVKMLKHISL
210 220 230 240 250
QRTGYGGTGS IEIPVLCLLV HGEPRILQKM YKNIQNSIPW LILAGSGGVA
260 270 280 290 300
DILVTLMDRG CWDADIVQEL LINTFPDGLH STEITSWTKL IQRILDHGHL
310 320 330 340 350
LTVHDPEQDS ELDTVILKAL VKACKSQSQE AQDFLDELKL AVAWNRVDIA
360 370 380 390 400
KSEIFSGDVQ WSAQDLEEVM MEALVNDKPD FVRLFVDNGV NIKQFLTYGR
410 420 430 440 450
LQELYCSVSE KNLLHTLLLK KNQERQAQLA RKRMSGNPNN ELGDRKFRFT
460 470 480 490 500
FHEVSKVLKD FLDDTCKGFY QKLPAERMGK GRLFHSQKNL PDMDRRCEHP
510 520 530 540 550
WRDLFLWAIL QNRQEMANYF WAMGPEAVAA ALVGCKIMKE MAHLATEAES
560 570 580 590 600
ARSMKNAKYE QFAMDLFSEC YSNSEDRAYS LLVRKTCCWS KATVLNIATL
610 620 630 640 650
AEAKCFFAHD GVQALLTKVW WGAMRTDTSI SRLVLTFFIP PLVWTSLIKF
660 670 680 690 700
NPEEQVSKDE GEPFAELDSL ETEQALLLTD GDPVAGEGSA ETAARSCSAT
710 720 730 740 750
FIRVVLRRWN RFWSAPVTVF MGNVIMYFAF LILFSYVLLL DFRPPPPYGP
760 770 780 790 800
SAAEIILYFW VFTLVLEEIR QSFFTDEDMS ILKKMKLYVE DNWNKCDMVA
810 820 830 840 850
ISLFVVGLSC RMAMSTYEAG RTVLALDFMV FTLRLIHIFA IHKQLGPKII
860 870 880 890 900
IVERMIKDVF FFLFFLSVWL IAYGVTTQAL LHPNDPRIDW VFRRALYRPY
910 920 930 940 950
LHIFGQIPLE EIDAAKMPDD NCTTDVQEII LGTLPPCPNI YANWLVILLL
960 970 980 990 1000
VIYLLVTNVL LLNLLIAMFS YTFQVVQENA DIFWKFQRYN LIVEYHSRPA
1010 1020 1030 1040 1050
LAPPFIIISH ITQALLSFIK KTENTQDLLE RELPSGLDQK LMTWETVQKE
1060 1070 1080 1090 1100
NYLAKLEHEH RESSGERLRY TSSKVQTLLR MVGGFKDQEK RMATVETEVR
1110 1120 1130 1140 1150
YCGEVLSWIA ECFHKSTLKC DRDAPKAPRS IAGSSRDQQP QGAKRQQPGG
1160
HPAYGTDKKL PFIDH
Length:1,165
Mass (Da):132,641
Last modified:October 16, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87816EABB94E5561
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KF305313 mRNA Translation: AGS55987.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF305313 mRNA Translation: AGS55987.1

3D structure databases

SMRiS5UH55
ModBaseiSearch...

Organism-specific databases

ZFINiZDB-GENE-060503-736, trpm5

Phylogenomic databases

OMAiRSENPWR

Family and domain databases

InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR002153, TRPC_channel
IPR029577, TRPM5
IPR041491, TRPM_SLOG
PANTHERiPTHR13800:SF5, PTHR13800:SF5, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit
PRINTSiPR01097, TRNSRECEPTRP

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS5UH55_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S5UH55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: September 29, 2021
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again