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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Scylla paramamosain (Mud crab)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiScylla paramamosain (Mud crab)Imported
Taxonomic identifieri85552 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeScylla

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Transmembranei52 – 76HelicalSequence analysisAdd BLAST25
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei128 – 149HelicalSequence analysisAdd BLAST22
Transmembranei161 – 180HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 181COX1InterPro annotationAdd BLAST181

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

S4SGR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GMISHIVSQE SGKKESFGTL GMIYAMMAIG ILGFIVWAHH MFTVGMDVDT
60 70 80 90 100
RAYFTSATMI IAVPTGIKIF SWLSTLHGTQ INYSPSMLWA LGFIFLFTVG
110 120 130 140 150
GLTGVVLANS SIDIILHDTY YVVAHFHYVL SMGAVFGIFA GIAHWFPLFT
160 170 180
GLSLNPKWMK IHFFIMFTGV NITFFPQHFL G
Length:181
Mass (Da):20,115
Last modified:October 16, 2013 - v1
Checksum:iC5F545F11CC82336
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei181Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ823041 Genomic DNA Translation: AFO54624.1
JQ823043 Genomic DNA Translation: AFO54626.1
JQ823047 Genomic DNA Translation: AFO54630.1
JQ823049 Genomic DNA Translation: AFO54632.1
JQ823052 Genomic DNA Translation: AFO54635.1
JQ823053 Genomic DNA Translation: AFO54636.1
JQ823054 Genomic DNA Translation: AFO54637.1
JX416422 Genomic DNA Translation: AGH88842.1
JX416423 Genomic DNA Translation: AGH88843.1
KM275631 Genomic DNA Translation: AKF17609.1
KM275633 Genomic DNA Translation: AKF17611.1
KM275634 Genomic DNA Translation: AKF17612.1

Similar proteinsi

Entry informationi

Entry nameiS4SGR1_SCYPA
AccessioniPrimary (citable) accession number: S4SGR1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: June 20, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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