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UniProtKB - S4R3K4 (S4R3K4_HUMAN)
Protein
Nuclear factor 1
Gene
NFIA
Organism
Homo sapiens (Human)
Status
Functioni
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
UniRule annotationGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | ActivatorUniRule annotation, DNA-bindingUniRule annotation |
Biological process | DNA replicationUniRule annotation, Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor 1UniRule annotation |
Gene namesi | Name:NFIA |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7784, NFIA |
VEuPathDBi | HostDB:ENSG00000162599 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000162599, Expressed in oviduct epithelium and 225 other tissues |
ExpressionAtlasi | S4R3K4, baseline and differential |
Interactioni
Subunit structurei
Binds DNA as a homodimer.
UniRule annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 147 | CTF/NF-IInterPro annotationAdd BLAST | 147 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 166 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the CTF/NF-I family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00950000182916 |
HOGENOMi | CLU_012576_0_0_1 |
OMAi | XSPHATP |
Family and domain databases
InterProi | View protein in InterPro IPR000647, CTF/NFI IPR020604, CTF/NFI_DNA-bd-dom IPR003619, MAD_homology1_Dwarfin-type |
PANTHERi | PTHR11492, PTHR11492, 1 hit |
Pfami | View protein in Pfam PF00859, CTF_NFI, 1 hit PF03165, MH1, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit |
PROSITEi | View protein in PROSITE PS51080, CTF_NFI_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
S4R3K4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKEEERAVK DELLSEKPEV KQKWASRLLA KLRKDIRPEY REDFVLTVTG
60 70 80 90 100
KKPPCCVLSN PDQKGKMRRI DCLRQADKVW RLDLVMVILF KGIPLESTDG
110 120 130 140 150
ERLVKSPQCS NPGLCVQPHH IGVSVKELDL YLAYFVHAAD SSQSESPSQP
160 170 180
SDADIKDQPE NGHLGFQDSF VTSGVFSVTE LVRVSQ
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12857 | NFIA_HUMAN | Nuclear factor 1 A-type | NFIA KIAA1439 | 509 | Annotation score: | ||
B1AKN8 | B1AKN8_HUMAN | Nuclear factor 1 | NFIA | 532 | Annotation score: | ||
B1AKN5 | B1AKN5_HUMAN | Nuclear factor 1 | NFIA | 487 | Annotation score: | ||
A0A590UK09 | A0A590UK09_HUMAN | Nuclear factor 1 | NFIA | 508 | Annotation score: | ||
B1AKN7 | B1AKN7_HUMAN | Nuclear factor 1 | NFIA | 466 | Annotation score: | ||
B1AKN6 | B1AKN6_HUMAN | Nuclear factor 1 | NFIA | 380 | Annotation score: | ||
A0A590UK73 | A0A590UK73_HUMAN | Nuclear factor 1 | NFIA | 326 | Annotation score: | ||
A0A590UJ82 | A0A590UJ82_HUMAN | CCAAT-box-binding transcription fac... | NFIA | 198 | Annotation score: | ||
S4R3W2 | S4R3W2_HUMAN | Nuclear factor 1 A-type | NFIA | 184 | Annotation score: | ||
A0A590UJU2 | A0A590UJU2_HUMAN | Nuclear factor 1 A-type | NFIA hCG_2032260 | 242 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 186 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092784 Genomic DNA No translation available. AC096534 Genomic DNA No translation available. AC096947 Genomic DNA No translation available. AC099792 Genomic DNA No translation available. AL096888 Genomic DNA No translation available. AL355795 Genomic DNA No translation available. AL445198 Genomic DNA No translation available. AL445432 Genomic DNA No translation available. KF495972 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000476646.5; ENSP00000474461.1; ENSG00000162599.17 |
UCSCi | uc057hbk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092784 Genomic DNA No translation available. AC096534 Genomic DNA No translation available. AC096947 Genomic DNA No translation available. AC099792 Genomic DNA No translation available. AL096888 Genomic DNA No translation available. AL355795 Genomic DNA No translation available. AL445198 Genomic DNA No translation available. AL445432 Genomic DNA No translation available. KF495972 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | S4R3K4 |
PeptideAtlasi | S4R3K4 |
Protocols and materials databases
Antibodypediai | 1812, 277 antibodies from 31 providers |
Genome annotation databases
Ensembli | ENST00000476646.5; ENSP00000474461.1; ENSG00000162599.17 |
UCSCi | uc057hbk.1, human |
Organism-specific databases
HGNCi | HGNC:7784, NFIA |
OpenTargetsi | ENSG00000162599 |
VEuPathDBi | HostDB:ENSG00000162599 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182916 |
HOGENOMi | CLU_012576_0_0_1 |
OMAi | XSPHATP |
Miscellaneous databases
ChiTaRSi | NFIA, human |
Gene expression databases
Bgeei | ENSG00000162599, Expressed in oviduct epithelium and 225 other tissues |
ExpressionAtlasi | S4R3K4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000647, CTF/NFI IPR020604, CTF/NFI_DNA-bd-dom IPR003619, MAD_homology1_Dwarfin-type |
PANTHERi | PTHR11492, PTHR11492, 1 hit |
Pfami | View protein in Pfam PF00859, CTF_NFI, 1 hit PF03165, MH1, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit |
PROSITEi | View protein in PROSITE PS51080, CTF_NFI_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S4R3K4_HUMAN | |
Accessioni | S4R3K4Primary (citable) accession number: S4R3K4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 18, 2013 |
Last sequence update: | September 18, 2013 | |
Last modified: | May 25, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |