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Protein

Nuclear factor 1

Gene

NFIA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processDNA replicationUniRule annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1UniRule annotation
Gene namesi
Name:NFIAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162599.15
HGNCiHGNC:7784 NFIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162599

PTM / Processingi

Proteomic databases

MaxQBiS4R3K4
PeptideAtlasiS4R3K4
PRIDEiS4R3K4

Expressioni

Gene expression databases

BgeeiENSG00000162599 Expressed in 211 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiS4R3K4 baseline and differential

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliS4R3K4
SMRiS4R3K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 147CTF/NF-IInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the CTF/NF-I family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3663 Eukaryota
ENOG410Y16G LUCA
GeneTreeiENSGT00390000009905

Family and domain databases

InterProiView protein in InterPro
IPR000647 CTF/NFI
IPR020604 CTF/NFI_DNA-bd-dom
IPR003619 MAD_homology1_Dwarfin-type
PANTHERiPTHR11492 PTHR11492, 1 hit
PfamiView protein in Pfam
PF00859 CTF_NFI, 1 hit
PF03165 MH1, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
PROSITEiView protein in PROSITE
PS51080 CTF_NFI_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

S4R3K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKEEERAVK DELLSEKPEV KQKWASRLLA KLRKDIRPEY REDFVLTVTG
60 70 80 90 100
KKPPCCVLSN PDQKGKMRRI DCLRQADKVW RLDLVMVILF KGIPLESTDG
110 120 130 140 150
ERLVKSPQCS NPGLCVQPHH IGVSVKELDL YLAYFVHAAD SSQSESPSQP
160 170 180
SDADIKDQPE NGHLGFQDSF VTSGVFSVTE LVRVSQ
Length:186
Mass (Da):20,966
Last modified:September 18, 2013 - v1
Checksum:iF283230A6131C20D
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12857NFIA_HUMAN
Nuclear factor 1 A-type
NFIA KIAA1439
509Annotation score:
B1AKN8B1AKN8_HUMAN
Nuclear factor 1
NFIA
532Annotation score:
B1AKN5B1AKN5_HUMAN
Nuclear factor 1
NFIA
487Annotation score:
B1AKN7B1AKN7_HUMAN
Nuclear factor 1
NFIA
466Annotation score:
B1AKN6B1AKN6_HUMAN
Nuclear factor 1
NFIA
380Annotation score:
S4R3W2S4R3W2_HUMAN
Nuclear factor 1 A-type
NFIA
184Annotation score:
S4R308S4R308_HUMAN
Nuclear factor 1 A-type
NFIA
95Annotation score:
S4R3K5S4R3K5_HUMAN
Nuclear factor 1 A-type
NFIA
157Annotation score:
S4R3W6S4R3W6_HUMAN
Nuclear factor 1 A-type
NFIA
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei186Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092784 Genomic DNA No translation available.
AC096534 Genomic DNA No translation available.
AC096947 Genomic DNA No translation available.
AC099792 Genomic DNA No translation available.
AL096888 Genomic DNA No translation available.
AL355795 Genomic DNA No translation available.
AL445198 Genomic DNA No translation available.
AL445432 Genomic DNA No translation available.
KF495972 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000476646; ENSP00000474461; ENSG00000162599
UCSCiuc057hbk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092784 Genomic DNA No translation available.
AC096534 Genomic DNA No translation available.
AC096947 Genomic DNA No translation available.
AC099792 Genomic DNA No translation available.
AL096888 Genomic DNA No translation available.
AL355795 Genomic DNA No translation available.
AL445198 Genomic DNA No translation available.
AL445432 Genomic DNA No translation available.
KF495972 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliS4R3K4
SMRiS4R3K4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiS4R3K4
PeptideAtlasiS4R3K4
PRIDEiS4R3K4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000476646; ENSP00000474461; ENSG00000162599
UCSCiuc057hbk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000162599.15
HGNCiHGNC:7784 NFIA
OpenTargetsiENSG00000162599
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3663 Eukaryota
ENOG410Y16G LUCA
GeneTreeiENSGT00390000009905

Miscellaneous databases

ChiTaRSiNFIA human

Gene expression databases

BgeeiENSG00000162599 Expressed in 211 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiS4R3K4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000647 CTF/NFI
IPR020604 CTF/NFI_DNA-bd-dom
IPR003619 MAD_homology1_Dwarfin-type
PANTHERiPTHR11492 PTHR11492, 1 hit
PfamiView protein in Pfam
PF00859 CTF_NFI, 1 hit
PF03165 MH1, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
PROSITEiView protein in PROSITE
PS51080 CTF_NFI_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS4R3K4_HUMAN
AccessioniPrimary (citable) accession number: S4R3K4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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