NFIA

Functionⁱ

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.UniRule annotation

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-UniRule
DNA-binding transcription factor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA replication Source: UniProtKB-UniRule
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	ActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological process	DNA replicationUniRule annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear factor 1UniRule annotation
Gene namesⁱ	Name:NFIAImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162599.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7784 NFIA

Keywords - Cellular componentⁱ

NucleusUniRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162599

OpenTargetsⁱ

ENSG00000162599

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	S4R3K4
PeptideAtlas More...PeptideAtlasⁱ	S4R3K4
PRIDEⁱ	S4R3K4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162599 Expressed in 211 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasⁱ	S4R3K4 baseline and differential

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	S4R3K4
SMRⁱ	S4R3K4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 147	CTF/NF-IInterPro annotationAdd BLAST		147

Sequence similaritiesⁱ

Belongs to the CTF/NF-I family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3663 Eukaryota ENOG410Y16G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009905

Family and domain databases

InterProⁱ	View protein in InterPro IPR000647 CTF/NFI IPR020604 CTF/NFI_DNA-bd-dom IPR003619 MAD_homology1_Dwarfin-type
PANTHERⁱ	PTHR11492 PTHR11492, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00859 CTF_NFI, 1 hit PF03165 MH1, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51080 CTF_NFI_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show all Align All

S4R3K4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKEEERAVK DELLSEKPEV KQKWASRLLA KLRKDIRPEY REDFVLTVTG 
        60         70         80         90        100
KKPPCCVLSN PDQKGKMRRI DCLRQADKVW RLDLVMVILF KGIPLESTDG 
       110        120        130        140        150
ERLVKSPQCS NPGLCVQPHH IGVSVKELDL YLAYFVHAAD SSQSESPSQP 
       160        170        180 
SDADIKDQPE NGHLGFQDSF VTSGVFSVTE LVRVSQ

Length:186

Mass (Da):20,966

Last modified:September 18, 2013 - v1

Checksum:ⁱF283230A6131C20D

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q12857	NFIA_HUMAN	Nuclear factor 1 A-type Nuclear factor 1 A-type, NF1-A, Nuclear factor 1/A (CCAAT-box-binding transcription factor, CTF) (Nuclear factor I/A, NF-I/A, NFI-A) (TGGCA-binding protein)	NFIA KIAA1439	509	Annotation score:
B1AKN8	B1AKN8_HUMAN	Nuclear factor 1 Nuclear factor 1	NFIA	532	Annotation score:
B1AKN5	B1AKN5_HUMAN	Nuclear factor 1 Nuclear factor 1	NFIA	487	Annotation score:
B1AKN7	B1AKN7_HUMAN	Nuclear factor 1 Nuclear factor 1	NFIA	466	Annotation score:
B1AKN6	B1AKN6_HUMAN	Nuclear factor 1 Nuclear factor 1	NFIA	380	Annotation score:
S4R3W2	S4R3W2_HUMAN	Nuclear factor 1 A-type Nuclear factor 1 A-type	NFIA	184	Annotation score:
S4R308	S4R308_HUMAN	Nuclear factor 1 A-type Nuclear factor 1 A-type	NFIA	95	Annotation score:
S4R3K5	S4R3K5_HUMAN	Nuclear factor 1 A-type Nuclear factor 1 A-type	NFIA	157	Annotation score:
S4R3W6	S4R3W6_HUMAN	Nuclear factor 1 A-type Nuclear factor 1 A-type	NFIA	47	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	186	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC092784 Genomic DNA No translation available. AC096534 Genomic DNA No translation available. AC096947 Genomic DNA No translation available. AC099792 Genomic DNA No translation available. AL096888 Genomic DNA No translation available. AL355795 Genomic DNA No translation available. AL445198 Genomic DNA No translation available. AL445432 Genomic DNA No translation available. KF495972 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC092784 Genomic DNA No translation available.
AC096534 Genomic DNA No translation available.
AC096947 Genomic DNA No translation available.
AC099792 Genomic DNA No translation available.
AL096888 Genomic DNA No translation available.
AL355795 Genomic DNA No translation available.
AL445198 Genomic DNA No translation available.
AL445432 Genomic DNA No translation available.
KF495972 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000476646; ENSP00000474461; ENSG00000162599
UCSC genome browser More...UCSCⁱ	uc057hbk.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
S4R3K4	Nuclear factor 1 (Fragment)		MUSPF		486	UniRef100_S4R3K4
Nuclear factor 1 (Fragment)		PANTR		225
Uncharacterized protein (Fragment)		AILME		270
Nuclear factor 1 (Fragment)		PONAB		186
UPI000CCC8B3B		MYOLU		590

Protein	Similar proteins		Species	Score	Length	Source
S4R3K4	Nuclear factor 1		DANRE		507	UniRef90_Q1L9B0
Nuclear factor 1		Asian bonytongue		511
Nuclear factor 1		ICTPU		507
Nuclear factor 1 (Fragment)		MUSPF		486
Nuclear factor 1 (Fragment)		PANTR		225
+9

Protein	Similar proteins		Species	Score	Length	Source
S4R3K4	Nuclear factor 1 X-type		HUMAN		502	UniRef50_Q14938
Nuclear factor 1 A-type		RAT		509
Nuclear factor 1 X-type		MOUSE		488
Nuclear factor 1		CALJA		502
Nuclear factor 1		DELLE		502
+695

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC092784 Genomic DNA No translation available. AC096534 Genomic DNA No translation available. AC096947 Genomic DNA No translation available. AC099792 Genomic DNA No translation available. AL096888 Genomic DNA No translation available. AL355795 Genomic DNA No translation available. AL445198 Genomic DNA No translation available. AL445432 Genomic DNA No translation available. KF495972 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC092784 Genomic DNA No translation available.
AC096534 Genomic DNA No translation available.
AC096947 Genomic DNA No translation available.
AC099792 Genomic DNA No translation available.
AL096888 Genomic DNA No translation available.
AL355795 Genomic DNA No translation available.
AL445198 Genomic DNA No translation available.
AL445432 Genomic DNA No translation available.
KF495972 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	S4R3K4
SMRⁱ	S4R3K4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	S4R3K4
PeptideAtlasⁱ	S4R3K4
PRIDEⁱ	S4R3K4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000476646; ENSP00000474461; ENSG00000162599
UCSCⁱ	uc057hbk.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162599.15
HGNCⁱ	HGNC:7784 NFIA
OpenTargetsⁱ	ENSG00000162599
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3663 Eukaryota ENOG410Y16G LUCA
GeneTreeⁱ	ENSGT00390000009905

Miscellaneous databases

ChiTaRSⁱ	NFIA human

ChiTaRSⁱ

NFIA human

Gene expression databases

Bgeeⁱ	ENSG00000162599 Expressed in 211 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasⁱ	S4R3K4 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000647 CTF/NFI IPR020604 CTF/NFI_DNA-bd-dom IPR003619 MAD_homology1_Dwarfin-type
PANTHERⁱ	PTHR11492 PTHR11492, 1 hit
Pfamⁱ	View protein in Pfam PF00859 CTF_NFI, 1 hit PF03165 MH1, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51080 CTF_NFI_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S4R3K4_HUMAN
Accessionⁱ	S4R3K4Primary (citable) accession number: S4R3K4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 18, 2013
	Last sequence update:	September 18, 2013
	Last modified:	November 7, 2018
	This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - S4R3K4 (S4R3K4_HUMAN)

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Nuclear factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ