The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - S4R334 (S4R334_HUMAN)
Protein
Cellular tumor antigen p53
Gene
TP53
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- apoptotic process Source: InterPro
- cell cycle Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProt
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | RepressorARBA annotation |
Biological process | Biological rhythmsARBA annotation, Cell cycleARBA annotation, NecrosisARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cellular tumor antigen p53ARBA annotationAlternative name(s): Tumor suppressor p53ARBA annotation |
Gene namesi | Name:TP53 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
VEuPathDBi | HostDB:ENSG00000141510 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix ARBA annotation
Nucleus
- PML body ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum ARBA annotation
Cytoskeleton
- centrosome ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
- PML body Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000141510, Expressed in epithelium of mammary gland and 188 other tissues |
ExpressionAtlasi | S4R334, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 29 | P53_TADInterPro annotationAdd BLAST | 24 | |
Domaini | 35 – 59 | TAD2InterPro annotationAdd BLAST | 25 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 97 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 92 | Pro residuesSequence analysisAdd BLAST | 29 |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR040926, p53_TAD2 IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF08563, P53_TAD, 1 hit PF18521, TAD2, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
S4R334-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI
60 70 80 90 100
EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ
110 120 130 140
KTYQGSYGFR LGFLHSGTAK SVTCTMFCQL AKTCPVQLWV DST
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04637 | P53_HUMAN | Cellular tumor antigen p53 | TP53 P53 | 393 | Annotation score: | ||
E7EQX7 | E7EQX7_HUMAN | Cellular tumor antigen p53 | TP53 | 285 | Annotation score: | ||
J3KP33 | J3KP33_HUMAN | Cellular tumor antigen p53 | TP53 | 343 | Annotation score: | ||
E7EMR6 | E7EMR6_HUMAN | Cellular tumor antigen p53 | TP53 | 165 | Annotation score: | ||
A0A0U1RQC9 | A0A0U1RQC9_HUMAN | Cellular tumor antigen p53 | TP53 | 410 | Annotation score: | ||
A0A087X1Q1 | A0A087X1Q1_HUMAN | Cellular tumor antigen p53 | TP53 | 234 | Annotation score: | ||
E9PFT5 | E9PFT5_HUMAN | Cellular tumor antigen p53 | TP53 | 155 | Annotation score: | ||
E9PCY9 | E9PCY9_HUMAN | Cellular tumor antigen p53 | TP53 | 127 | Annotation score: | ||
A0A087WT22 | A0A087WT22_HUMAN | Cellular tumor antigen p53 | TP53 | 187 | Annotation score: | ||
A0A087WXZ1 | A0A087WXZ1_HUMAN | Cellular tumor antigen p53 | TP53 | 182 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 143 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000604348.5; ENSP00000473895.1; ENSG00000141510.18 |
UCSCi | uc060avc.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | S4R334 |
PRIDEi | S4R334 |
Protocols and materials databases
Antibodypediai | 3525, 9276 antibodies from 63 providers |
Genome annotation databases
Ensembli | ENST00000604348.5; ENSP00000473895.1; ENSG00000141510.18 |
UCSCi | uc060avc.1, human |
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
OpenTargetsi | ENSG00000141510 |
VEuPathDBi | HostDB:ENSG00000141510 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
Miscellaneous databases
ChiTaRSi | TP53, human |
Gene expression databases
Bgeei | ENSG00000141510, Expressed in epithelium of mammary gland and 188 other tissues |
ExpressionAtlasi | S4R334, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR040926, p53_TAD2 IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF08563, P53_TAD, 1 hit PF18521, TAD2, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S4R334_HUMAN | |
Accessioni | S4R334Primary (citable) accession number: S4R334 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 18, 2013 |
Last sequence update: | September 18, 2013 | |
Last modified: | May 25, 2022 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |