UniProtKB - S4R334 (S4R334_HUMAN)
Protein
Submitted name:
Cellular tumor antigen p53
Gene
TP53
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- apoptotic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Cellular tumor antigen p53Imported |
Gene namesi | Name:TP53Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11998 TP53 |
Subcellular locationi
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000141510 Expressed in 170 organ(s), highest expression level in epithelium of mammary gland |
ExpressionAtlasi | S4R334 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 30 | P53_TADInterPro annotationAdd BLAST | 25 | |
Domaini | 35 – 59 | TAD2InterPro annotationAdd BLAST | 25 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 97 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 92 | Pro-richSequence analysisAdd BLAST | 29 |
Phylogenomic databases
eggNOGi | ENOG410IITK Eukaryota ENOG410ZSWV LUCA |
GeneTreei | ENSGT00950000183153 |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR012346 p53/RUNT-type_TF_DNA-bd_sf IPR040926 p53_TAD2 IPR013872 p53_transactivation_domain IPR002117 p53_tumour_suppressor |
PANTHERi | PTHR11447 PTHR11447, 1 hit |
Pfami | View protein in Pfam PF08563 P53_TAD, 1 hit PF18521 TAD2, 1 hit |
SUPFAMi | SSF49417 SSF49417, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
S4R334-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI
60 70 80 90 100
EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ
110 120 130 140
KTYQGSYGFR LGFLHSGTAK SVTCTMFCQL AKTCPVQLWV DST
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04637 | P53_HUMAN | Cellular tumor antigen p53 | TP53 P53 | 393 | Annotation score: | ||
A0A087WZU8 | A0A087WZU8_HUMAN | Cellular tumor antigen p53 | TP53 | 382 | Annotation score: | ||
E7EQX7 | E7EQX7_HUMAN | Cellular tumor antigen p53 | TP53 | 285 | Annotation score: | ||
J3KP33 | J3KP33_HUMAN | Cellular tumor antigen p53 | TP53 | 343 | Annotation score: | ||
A0A0U1RQC9 | A0A0U1RQC9_HUMAN | Cellular tumor antigen p53 | TP53 | 410 | Annotation score: | ||
A0A087X1Q1 | A0A087X1Q1_HUMAN | Cellular tumor antigen p53 | TP53 | 234 | Annotation score: | ||
A0A087WT22 | A0A087WT22_HUMAN | Cellular tumor antigen p53 | TP53 | 187 | Annotation score: | ||
A0A087WXZ1 | A0A087WXZ1_HUMAN | Cellular tumor antigen p53 | TP53 | 182 | Annotation score: | ||
E7ESS1 | E7ESS1_HUMAN | Cellular tumor antigen p53 | TP53 | 199 | Annotation score: | ||
E9PFT5 | E9PFT5_HUMAN | Cellular tumor antigen p53 | TP53 | 155 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 143 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000604348; ENSP00000473895; ENSG00000141510 |
UCSCi | uc060avc.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
jPOSTi | S4R334 |
PeptideAtlasi | S4R334 |
PRIDEi | S4R334 |
Genome annotation databases
Ensembli | ENST00000604348; ENSP00000473895; ENSG00000141510 |
UCSCi | uc060avc.1 human |
Organism-specific databases
HGNCi | HGNC:11998 TP53 |
OpenTargetsi | ENSG00000141510 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IITK Eukaryota ENOG410ZSWV LUCA |
GeneTreei | ENSGT00950000183153 |
Miscellaneous databases
ChiTaRSi | TP53 human |
Gene expression databases
Bgeei | ENSG00000141510 Expressed in 170 organ(s), highest expression level in epithelium of mammary gland |
ExpressionAtlasi | S4R334 baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR012346 p53/RUNT-type_TF_DNA-bd_sf IPR040926 p53_TAD2 IPR013872 p53_transactivation_domain IPR002117 p53_tumour_suppressor |
PANTHERi | PTHR11447 PTHR11447, 1 hit |
Pfami | View protein in Pfam PF08563 P53_TAD, 1 hit PF18521 TAD2, 1 hit |
SUPFAMi | SSF49417 SSF49417, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S4R334_HUMAN | |
Accessioni | S4R334Primary (citable) accession number: S4R334 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 18, 2013 |
Last sequence update: | September 18, 2013 | |
Last modified: | November 13, 2019 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |