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Entry version 46 (31 Jul 2019)
Sequence version 3 (30 Nov 2016)
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Protein
Submitted name:

Ankyrin-2

Gene

Ank2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ank2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88025 Ank2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
S4R2R5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
S4R2R5

PeptideAtlas

More...
PeptideAtlasi
S4R2R5

PRoteomics IDEntifications database

More...
PRIDEi
S4R2R5

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S4R2R5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032826 Expressed in 231 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
S4R2R5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
S4R2R5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 759ANK_REP_REGIONInterPro annotationAdd BLAST751
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 74ANKPROSITE-ProRule annotationAdd BLAST33
Repeati75 – 107ANKPROSITE-ProRule annotationAdd BLAST33
Repeati108 – 140ANKPROSITE-ProRule annotationAdd BLAST33
Repeati211 – 243ANKPROSITE-ProRule annotationAdd BLAST33
Repeati244 – 276ANKPROSITE-ProRule annotationAdd BLAST33
Repeati277 – 309ANKPROSITE-ProRule annotationAdd BLAST33
Repeati310 – 342ANKPROSITE-ProRule annotationAdd BLAST33
Repeati343 – 375ANKPROSITE-ProRule annotationAdd BLAST33
Repeati376 – 408ANKPROSITE-ProRule annotationAdd BLAST33
Repeati409 – 441ANKPROSITE-ProRule annotationAdd BLAST33
Repeati442 – 474ANKPROSITE-ProRule annotationAdd BLAST33
Repeati475 – 507ANKPROSITE-ProRule annotationAdd BLAST33
Repeati508 – 540ANKPROSITE-ProRule annotationAdd BLAST33
Repeati541 – 573ANKPROSITE-ProRule annotationAdd BLAST33
Repeati574 – 606ANKPROSITE-ProRule annotationAdd BLAST33
Repeati607 – 639ANKPROSITE-ProRule annotationAdd BLAST33
Repeati640 – 672ANKPROSITE-ProRule annotationAdd BLAST33
Repeati673 – 705ANKPROSITE-ProRule annotationAdd BLAST33
Repeati706 – 738ANKPROSITE-ProRule annotationAdd BLAST33
Domaini914 – 1069ZU5InterPro annotationAdd BLAST156
Domaini1071 – 1217ZU5InterPro annotationAdd BLAST147
Domaini3463 – 3547DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1371 – 1397DisorderedSequence analysisAdd BLAST27
Regioni1535 – 1971DisorderedSequence analysisAdd BLAST437
Regioni2003 – 2037DisorderedSequence analysisAdd BLAST35
Regioni2119 – 2237DisorderedSequence analysisAdd BLAST119
Regioni2260 – 2382DisorderedSequence analysisAdd BLAST123
Regioni2408 – 2771DisorderedSequence analysisAdd BLAST364
Regioni2811 – 2837DisorderedSequence analysisAdd BLAST27
Regioni2873 – 2925DisorderedSequence analysisAdd BLAST53
Regioni2967 – 3004DisorderedSequence analysisAdd BLAST38
Regioni3029 – 3360DisorderedSequence analysisAdd BLAST332
Regioni3384 – 3405DisorderedSequence analysisAdd BLAST22
Regioni3584 – 3729DisorderedSequence analysisAdd BLAST146
Regioni3794 – 3816DisorderedSequence analysisAdd BLAST23
Regioni3834 – 3859DisorderedSequence analysisAdd BLAST26
Regioni3871 – 3900DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1381 – 1397PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1573 – 1603PolarSequence analysisAdd BLAST31
Compositional biasi1623 – 1655PolyampholyteSequence analysisAdd BLAST33
Compositional biasi1677 – 1715PolyampholyteSequence analysisAdd BLAST39
Compositional biasi1718 – 1772PolarSequence analysisAdd BLAST55
Compositional biasi1791 – 1809PolarSequence analysisAdd BLAST19
Compositional biasi1912 – 1954PolyampholyteSequence analysisAdd BLAST43
Compositional biasi1955 – 1971PolarSequence analysisAdd BLAST17
Compositional biasi2011 – 2029PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2119 – 2133PolarSequence analysisAdd BLAST15
Compositional biasi2159 – 2185PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2186 – 2206PolarSequence analysisAdd BLAST21
Compositional biasi2207 – 2227PolyampholyteSequence analysisAdd BLAST21
Compositional biasi2260 – 2281PolarSequence analysisAdd BLAST22
Compositional biasi2420 – 2458PolarSequence analysisAdd BLAST39
Compositional biasi2465 – 2520PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2555 – 2579PolarSequence analysisAdd BLAST25
Compositional biasi2595 – 2618PolarSequence analysisAdd BLAST24
Compositional biasi2629 – 2650PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2662 – 2693PolarSequence analysisAdd BLAST32
Compositional biasi2697 – 2732PolyampholyteSequence analysisAdd BLAST36
Compositional biasi2735 – 2753PolarSequence analysisAdd BLAST19
Compositional biasi2814 – 2837PolarSequence analysisAdd BLAST24
Compositional biasi2882 – 2896PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2969 – 3000PolarSequence analysisAdd BLAST32
Compositional biasi3075 – 3093AcidicSequence analysisAdd BLAST19
Compositional biasi3098 – 3138PolarSequence analysisAdd BLAST41
Compositional biasi3225 – 3239PolyampholyteSequence analysisAdd BLAST15
Compositional biasi3247 – 3277PolarSequence analysisAdd BLAST31
Compositional biasi3299 – 3328PolyampholyteSequence analysisAdd BLAST30
Compositional biasi3337 – 3352PolarSequence analysisAdd BLAST16
Compositional biasi3384 – 3398PolyampholyteSequence analysisAdd BLAST15
Compositional biasi3584 – 3603PolyampholyteSequence analysisAdd BLAST20
Compositional biasi3636 – 3657PolarSequence analysisAdd BLAST22
Compositional biasi3690 – 3704PolarSequence analysisAdd BLAST15
Compositional biasi3834 – 3854PolarSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Database of Orthologous Groups

More...
OrthoDBi
1011028at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 6 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 19 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

S4R2R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
60 70 80 90 100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA
110 120 130 140 150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL
160 170 180 190 200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ
210 220 230 240 250
SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF TARNGITPLH
260 270 280 290 300
VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH DQVVELLLER
310 320 330 340 350
KAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQYKAPVDDV TLDYLTALHV
360 370 380 390 400
AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG
410 420 430 440 450
ASIQAITESG LTPIHVAAFM GHLNIVLLLL QNGASPDVTN IRGETALHMA
460 470 480 490 500
ARAGQVEVVR CLLRNGALVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA
510 520 530 540 550
HPDAATTNGY TPLHISAREG QVDVASVLLE AGAAHSLATK KGFTPLHVAA
560 570 580 590 600
KYGSLDVAKL LLQRRAAADS AGKNGYTPLH IAAKKNQMQI ASTLLNYGAE
610 620 630 640 650
TNTVTKQGVT PLHLASQEGH TDMVTLLLDK GANIHMSTKS GLTSLHLAAQ
660 670 680 690 700
EDKVNVADIL TKHGADRDAY TKLGYTPLIV ACHYGNVKMV NFLLKQGANV
710 720 730 740 750
NAKTKNGYTP LHQAAQQGHT HIINVLLQHG AKPNATTANG NTALAIAKRL
760 770 780 790 800
GYISVVDTLK VVTEEVTTTT TTITEKHKLN VPETMTEVLD VSDEEGDDTV
810 820 830 840 850
TGDGGEYLRP EDLKELGDDS LPSSQFLDGM NYLRYSLEGG RSDSLRSFSS
860 870 880 890 900
DRSHTLSHAS YLRDSAMIDD TVVIPSHQVS ALAKEAERNS YRLSWGTENL
910 920 930 940 950
DNVALSSSPI HSGFLVSFMV DARGGAMRGC RHNGLRIIIP PRKCTAPTRV
960 970 980 990 1000
TCRLVKRHRL ATMPPMVEGE GLASRLIEVG PSGAQFLGPV IVEIPHFAAL
1010 1020 1030 1040 1050
RGKERELVVL RSENGDSWKE HFCDYTEDEL NEILNGMDEV LDSPEDLEKK
1060 1070 1080 1090 1100
RICRIITRDF PQYFAVVSRI KQDSNLIGPE GGVLSSTVVS QVQAVFPEGA
1110 1120 1130 1140 1150
LTKRIRVGLQ AQPMHSELVK KILGNKATFS PIVTLEPRRR KFHKPITMTI
1160 1170 1180 1190 1200
PVPKASSDVM LNGFGGDAPT LRLLCSITGG TTPAQWEDIT GTTPLTFVNE
1210 1220 1230 1240 1250
CVSFTTNVSA RFWLIDCRQI QESVAFASQV YREIICVPYM AKFVVFAKSH
1260 1270 1280 1290 1300
DPIEARLRCF CMTDDKVDKT LEQQENFSEV ARSRDVEVLE GKPIYVDCFG
1310 1320 1330 1340 1350
NLVPLTKSGQ HHIFSFFAFK ENRLPLFVKV RDTTQEPCGR LSFMKEPKST
1360 1370 1380 1390 1400
RGLVHQAICN LNITLPIYAK ESESDQEPEE EIGMTSEKND ETESTETSVL
1410 1420 1430 1440 1450
KSHLVNEVPV LASPDLLSEV SEMKQDLIKM TAILTTDVSD KAGSLKVKEL
1460 1470 1480 1490 1500
AKAGEEEPGE PFEIVERVKE DLEKVNAILR SGTCMRDEGR ARSSQSEREL
1510 1520 1530 1540 1550
EEEWVIVSDE EIQEAKQHAP VEIDEHPCIE VRVDRETKAK VEKDSTGLVN
1560 1570 1580 1590 1600
YLTDDLNSYT SPHEKKPHTA PEKSGETSQA SAVGKSSESN KGKATSAEEK
1610 1620 1630 1640 1650
QSAQKQLKPG LAIKKPVRRK LKEKQKQKEE SSQSSEEKTE LKKGSSEESV
1660 1670 1680 1690 1700
DEDRGLVPEP LPTAKATSPL IEETPIGSIK DKVKALQKRV EDEQKGRSKL
1710 1720 1730 1740 1750
PVRVKGKEDV PKRTTPRTHP AVSPSSKSST SSKAERHSSL SSSAKPERHT
1760 1770 1780 1790 1800
PVSPSSKNEK LSPVSPSAKT ERHSPVFSGK PEKHSPGSPS TKNERHSPVS
1810 1820 1830 1840 1850
SLKTERHTPG SPSGKTDKRP PVPSSGRTEK HPPVSPGKTE KHLPGSPSIR
1860 1870 1880 1890 1900
TPEKPAPGSA TGKHEKHLPV SPGKTEKQPP ISPTSKTERI EETMSVRELM
1910 1920 1930 1940 1950
KAFQSGQDPS KHKTGLFEHK SAKQKQPQDK SKSRVEKEKG HTVTQRETQR
1960 1970 1980 1990 2000
IESQTAKRGQ RFQVSAATES RRFRSTTITV GLRMEDPVRE RFERTPIIKT
2010 2020 2030 2040 2050
PEVVPSVAAE ESHRGSEKIV DEQGDMDFQI SPDRKTSTDF SEVIKQELED
2060 2070 2080 2090 2100
NDKYQQFRLT EDTEKAQVHL DQVITSPFNT AFPLDYMKDE FLPALSLQSG
2110 2120 2130 2140 2150
ALGGSSESLK QEVIAGSPCS SLMEGTPQIS SEESYKHEGL AETPETSPES
2160 2170 2180 2190 2200
LSFSPKKSEE QIGEAKETTK VGTPTDIHSE KELPITNDIT DSSQKQGAGV
2210 2220 2230 2240 2250
TRGSEPSTEH SQKEVTQDPH KDVCSKQDGC PESQSVSLAS EVFTEKGSCG
2260 2270 2280 2290 2300
ESQLPLVSSA FKTQSESETQ ESLTPSEVTK PFPPSDASVK TAEGTEPKPQ
2310 2320 2330 2340 2350
GAIRSPQGLE LPLPNRDSEV LSPMADESLA VSHKDSLEAS PVLEDNSSHK
2360 2370 2380 2390 2400
TPDSLEPSPL KESPCRDSLE SSPVEPKMKA GILPSHFPLP AAIAKTDLVA
2410 2420 2430 2440 2450
EVASMRSRLL RDPDGSAEDD SLEQTSLMES SGKSPLSPDT PSSEEVSYEV
2460 2470 2480 2490 2500
TPKPSDSSTP KPAVIHECAE EDDSENGEKK RFTPEEEMFK MVTKIKTFDE
2510 2520 2530 2540 2550
LEQEAKQKRD YKKEPRQDGS SSASDPDADY SAEVNDEKQM AGTEGEGEVP
2560 2570 2580 2590 2600
VLVTSENRKV SSSSSESEPE LTQLSKGADS GLLTEPVIRV QPPSPLPSSI
2610 2620 2630 2640 2650
DSNSSPEEAT QFQPIVPKQY TFKMNEEIQE EPATSEDKDC KSHLAEDSQT
2660 2670 2680 2690 2700
HSADAADGSD GDLNRETTQP ETCDGHGCET VSPSNSATPV SLGVQSPEHK
2710 2720 2730 2740 2750
DVDKPLAIDK DSLAHQDTCE NDREEREFDP SGVESTQADL PNESSSLSSR
2760 2770 2780 2790 2800
CAIPEGNESA KEIASPSSPV KVEVTITDQA LESMPEDCPI QDSSTTMQTE
2810 2820 2830 2840 2850
RFAMDVPVSE LAETDENSDP QIISPYENVP SSSFFSAEPS KIQTDTCHST
2860 2870 2880 2890 2900
VVHSPEVYSV IIRSSPEDVV VTNSSNRTVS GEESHCESHD LETESEQKSA
2910 2920 2930 2940 2950
LWAAQSDAPP LAVAPTASDA ASVTGEQASK VIITKTDADA DSWSEIREDD
2960 2970 2980 2990 3000
AAFEARVKEE EQKIFGLMVD RQSQGTTPDT TPARTPTEEG TPTSEQNPFL
3010 3020 3030 3040 3050
FQEGKLFEMT RSGAIDMTKR PYADESLHFF QIGQESNEEA ISEDLKEGAT
3060 3070 3080 3090 3100
GAEPPQTETT SESLELSEPK EAMDDEGELL PDDVSEEIED LPASDANIDS
3110 3120 3130 3140 3150
QVIISASTET PTKEAVSTAV EEPPTTQRSD SLSTVKQTPR PAVPGPVGQL
3160 3170 3180 3190 3200
DFSPVTRSVY SGQDDESPES SPEEQKSVIE IPTAPVDNVP SAESKPQIPI
3210 3220 3230 3240 3250
RTLPTLVPAP PSAEDESAFS DDFPSSLDED SKEGGAKPKS KIPVKAPTQR
3260 3270 3280 3290 3300
TEWQPSPTDI PLQKTAVPQG QETLSRAPDG RSKSESDASS LDAKTKCPVK
3310 3320 3330 3340 3350
ARSYIETETE SRERAEGFES ESEDGATKPK LFASRLPVKS RSTSSSGRPG
3360 3370 3380 3390 3400
TSPTRESREH FFDLYRNSIE FFEEISDEAS KLVDRLTQSE REQEPPSDDE
3410 3420 3430 3440 3450
SSSALEVSVI ESLPPVDIEH SAPEDIFDTR PIWDESIETM IERIPDENGH
3460 3470 3480 3490 3500
DRAEDPQDEQ ERMEERLAYI ADHLGFSWTE LARELDFTEE QIHQIRIENP
3510 3520 3530 3540 3550
NSLQDQSHAL LKYWLERDGK HATDTILIEC LTKINRMDIV HLLETNTEPL
3560 3570 3580 3590 3600
QERMGRSYAE IEQTITLDHS EGFSVLPDEL CAAKEKKEQE ASKESESSDH
3610 3620 3630 3640 3650
PPMVSEEDIS VGYSTFQDCL PKTEGDSPAA ALSPQMHQEP VQQDFSGKTQ
3660 3670 3680 3690 3700
DQQEYYVTTP GAEVEDPQKA TAVPDSLCKT PEDISTPPEG TKPCLQTPVT
3710 3720 3730 3740 3750
SERGSPIVQE PEEASEPKEE SSPRKTSLVI VESTDDQSQV FERLDGDAAF
3760 3770 3780 3790 3800
QKGDDMPDIP PETVTEEEYV DENGHTVVKK VTRKIIRRYV SSDGTEKEEV
3810 3820 3830 3840 3850
TMQGMPQEPV NIEDGDNYSK VIKRVVLKSD TQQSEVTLSE PSVLSSTSQF
3860 3870 3880 3890 3900
QAEPVEGRRV SKVVKTTMVH GERMEKSLGD SSLATDLPSA KDDFEEDNNE
Length:3,900
Mass (Da):426,434
Last modified:November 30, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i343C6B9AB4562435
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C8R3ANK2_MOUSE
Ankyrin-2
Ank2 AnkB
3,898Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2F3S4R2F3_MOUSE
Ankyrin-2
Ank2
3,926Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1U2S4R1U2_MOUSE
Ankyrin-2
Ank2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1M4S4R1M4_MOUSE
Ankyrin-2
Ank2
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2T7S4R2T7_MOUSE
Ankyrin-2
Ank2
1,219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRM9A0A087WRM9_MOUSE
Ankyrin-2
Ank2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1I1S4R1I1_MOUSE
Ankyrin-2
Ank2
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1J9S4R1J9_MOUSE
Ankyrin-2
Ank2
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2D6S4R2D6_MOUSE
Ankyrin-2
Ank2
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1B7S4R1B7_MOUSE
Ankyrin-2
Ank2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC102480 Genomic DNA No translation available.
AC102591 Genomic DNA No translation available.
AC105163 Genomic DNA No translation available.
AC113952 Genomic DNA No translation available.
AC131744 Genomic DNA No translation available.
AC157817 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001314868.1, NM_001327939.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000182078; ENSMUSP00000138753; ENSMUSG00000032826

Database of genes from NCBI RefSeq genomes

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GeneIDi
109676

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102480 Genomic DNA No translation available.
AC102591 Genomic DNA No translation available.
AC105163 Genomic DNA No translation available.
AC113952 Genomic DNA No translation available.
AC131744 Genomic DNA No translation available.
AC157817 Genomic DNA No translation available.
RefSeqiNP_001314868.1, NM_001327939.1

3D structure databases

SMRiS4R2R5
ModBaseiSearch...

PTM databases

SwissPalmiS4R2R5

Proteomic databases

jPOSTiS4R2R5
MaxQBiS4R2R5
PeptideAtlasiS4R2R5
PRIDEiS4R2R5

Genome annotation databases

EnsembliENSMUST00000182078; ENSMUSP00000138753; ENSMUSG00000032826
GeneIDi109676

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
287
MGIiMGI:88025 Ank2

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155279
OrthoDBi1011028at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ank2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032826 Expressed in 231 organ(s), highest expression level in cerebellum
ExpressionAtlasiS4R2R5 baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 6 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 19 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4R2R5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S4R2R5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: November 30, 2016
Last modified: July 31, 2019
This is version 46 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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