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Entry version 58 (29 Sep 2021)
Sequence version 3 (30 Nov 2016)
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Protein
Submitted name:

Ankyrin-2

Gene

Ank2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ank2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88025, Ank2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000032826

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
S4R2F3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
S4R2F3

PeptideAtlas

More...
PeptideAtlasi
S4R2F3

PRoteomics IDEntifications database

More...
PRIDEi
S4R2F3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
320594

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
S4R2F3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032826, Expressed in cerebellum and 256 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
S4R2F3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 95ANKPROSITE-ProRule annotationAdd BLAST33
Repeati96 – 128ANKPROSITE-ProRule annotationAdd BLAST33
Repeati129 – 161ANKPROSITE-ProRule annotationAdd BLAST33
Repeati232 – 264ANKPROSITE-ProRule annotationAdd BLAST33
Repeati265 – 297ANKPROSITE-ProRule annotationAdd BLAST33
Repeati298 – 330ANKPROSITE-ProRule annotationAdd BLAST33
Repeati331 – 363ANKPROSITE-ProRule annotationAdd BLAST33
Repeati364 – 396ANKPROSITE-ProRule annotationAdd BLAST33
Repeati397 – 429ANKPROSITE-ProRule annotationAdd BLAST33
Repeati430 – 462ANKPROSITE-ProRule annotationAdd BLAST33
Repeati463 – 495ANKPROSITE-ProRule annotationAdd BLAST33
Repeati496 – 528ANKPROSITE-ProRule annotationAdd BLAST33
Repeati529 – 561ANKPROSITE-ProRule annotationAdd BLAST33
Repeati562 – 594ANKPROSITE-ProRule annotationAdd BLAST33
Repeati595 – 627ANKPROSITE-ProRule annotationAdd BLAST33
Repeati628 – 660ANKPROSITE-ProRule annotationAdd BLAST33
Repeati661 – 693ANKPROSITE-ProRule annotationAdd BLAST33
Repeati694 – 726ANKPROSITE-ProRule annotationAdd BLAST33
Repeati727 – 759ANKPROSITE-ProRule annotationAdd BLAST33
Repeati760 – 792ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini968 – 1156ZU5InterPro annotationAdd BLAST189
Domaini1158 – 1304ZU5InterPro annotationAdd BLAST147
Domaini3550 – 3634DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni1458 – 1483DisorderedSequence analysisAdd BLAST26
Regioni1622 – 2058DisorderedSequence analysisAdd BLAST437
Regioni2090 – 2124DisorderedSequence analysisAdd BLAST35
Regioni2206 – 2324DisorderedSequence analysisAdd BLAST119
Regioni2347 – 2469DisorderedSequence analysisAdd BLAST123
Regioni2495 – 2858DisorderedSequence analysisAdd BLAST364
Regioni2960 – 3012DisorderedSequence analysisAdd BLAST53
Regioni3054 – 3091DisorderedSequence analysisAdd BLAST38
Regioni3116 – 3447DisorderedSequence analysisAdd BLAST332
Regioni3471 – 3492DisorderedSequence analysisAdd BLAST22
Regioni3671 – 3824DisorderedSequence analysisAdd BLAST154
Regioni3881 – 3903DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 31Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1468 – 1483Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1660 – 1690Polar residuesSequence analysisAdd BLAST31
Compositional biasi1710 – 1742Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi1764 – 1802Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi1805 – 1859Polar residuesSequence analysisAdd BLAST55
Compositional biasi1878 – 1896Polar residuesSequence analysisAdd BLAST19
Compositional biasi1999 – 2041Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi2042 – 2058Polar residuesSequence analysisAdd BLAST17
Compositional biasi2098 – 2116Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2206 – 2220Polar residuesSequence analysisAdd BLAST15
Compositional biasi2246 – 2272Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi2273 – 2293Polar residuesSequence analysisAdd BLAST21
Compositional biasi2294 – 2314Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi2347 – 2368Polar residuesSequence analysisAdd BLAST22
Compositional biasi2507 – 2545Polar residuesSequence analysisAdd BLAST39
Compositional biasi2552 – 2607Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi2642 – 2666Polar residuesSequence analysisAdd BLAST25
Compositional biasi2682 – 2705Polar residuesSequence analysisAdd BLAST24
Compositional biasi2716 – 2737Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2749 – 2780Polar residuesSequence analysisAdd BLAST32
Compositional biasi2784 – 2819Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi2822 – 2840Polar residuesSequence analysisAdd BLAST19
Compositional biasi2969 – 2983Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3056 – 3087Polar residuesSequence analysisAdd BLAST32
Compositional biasi3162 – 3180Acidic residuesSequence analysisAdd BLAST19
Compositional biasi3185 – 3225Polar residuesSequence analysisAdd BLAST41
Compositional biasi3312 – 3326Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3334 – 3364Polar residuesSequence analysisAdd BLAST31
Compositional biasi3386 – 3415Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3424 – 3439Polar residuesSequence analysisAdd BLAST16
Compositional biasi3471 – 3485Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3671 – 3690Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi3723 – 3744Polar residuesSequence analysisAdd BLAST22
Compositional biasi3777 – 3791Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

S4R2F3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY
60 70 80 90 100
LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA
110 120 130 140 150
LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL
160 170 180 190 200
ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA
210 220 230 240 250
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT
260 270 280 290 300
LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL
310 320 330 340 350
TPLHCAARSG HDQVVELLLE RKAPLLARTK NGLSPLHMAA QGDHVECVKH
360 370 380 390 400
LLQYKAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT
410 420 430 440 450
PLHIACKKNR IKVMELLVKY GASIQAITES GLTPIHVAAF MGHLNIVLLL
460 470 480 490 500
LQNGASPDVT NIRGETALHM AARAGQVEVV RCLLRNGALV DARAREEQTP
510 520 530 540 550
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVDVASVLL
560 570 580 590 600
EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL
610 620 630 640 650
HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN
660 670 680 690 700
YGAETNTVTK QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH
710 720 730 740 750
LAAQEDKVNV ADILTKHGAD RDAYTKLGYT PLIVACHYGN VKMVNFLLKQ
760 770 780 790 800
GANVNAKTKN GYTPLHQAAQ QGHTHIINVL LQHGAKPNAT TANGNTALAI
810 820 830 840 850
AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT EVLDVSDEEG
860 870 880 890 900
DDTVTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR
910 920 930 940 950
SFSSDRSHTL SHASYLRDSA MIDDTVVIPS HQVSALAKEA ERNSYRLSWG
960 970 980 990 1000
TENLDNVALS SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA
1010 1020 1030 1040 1050
PTRVTCRLVK RHRLATMPPM VEGEGLASRL IEVGPSGAQF LGKLHLPTAP
1060 1070 1080 1090 1100
PPLNEGESLV SRILQLGPPG TKFLGPVIVE IPHFAALRGK ERELVVLRSE
1110 1120 1130 1140 1150
NGDSWKEHFC DYTEDELNEI LNGMDEVLDS PEDLEKKRIC RIITRDFPQY
1160 1170 1180 1190 1200
FAVVSRIKQD SNLIGPEGGV LSSTVVSQVQ AVFPEGALTK RIRVGLQAQP
1210 1220 1230 1240 1250
MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG
1260 1270 1280 1290 1300
FGGDAPTLRL LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW
1310 1320 1330 1340 1350
LIDCRQIQES VAFASQVYRE IICVPYMAKF VVFAKSHDPI EARLRCFCMT
1360 1370 1380 1390 1400
DDKVDKTLEQ QENFSEVARS RDVEVLEGKP IYVDCFGNLV PLTKSGQHHI
1410 1420 1430 1440 1450
FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL VHQAICNLNI
1460 1470 1480 1490 1500
TLPIYAKESE SDQEPEEEIG MTSEKNDETE STETSVLKSH LVNEVPVLAS
1510 1520 1530 1540 1550
PDLLSEVSEM KQDLIKMTAI LTTDVSDKAG SLKVKELAKA GEEEPGEPFE
1560 1570 1580 1590 1600
IVERVKEDLE KVNAILRSGT CMRDEGRARS SQSERELEEE WVIVSDEEIQ
1610 1620 1630 1640 1650
EAKQHAPVEI DEHPCIEVRV DRETKAKVEK DSTGLVNYLT DDLNSYTSPH
1660 1670 1680 1690 1700
EKKPHTAPEK SGETSQASAV GKSSESNKGK ATSAEEKQSA QKQLKPGLAI
1710 1720 1730 1740 1750
KKPVRRKLKE KQKQKEESSQ SSEEKTELKK GSSEESVDED RGLVPEPLPT
1760 1770 1780 1790 1800
AKATSPLIEE TPIGSIKDKV KALQKRVEDE QKGRSKLPVR VKGKEDVPKR
1810 1820 1830 1840 1850
TTPRTHPAVS PSSKSSTSSK AERHSSLSSS AKPERHTPVS PSSKNEKLSP
1860 1870 1880 1890 1900
VSPSAKTERH SPVFSGKPEK HSPGSPSTKN ERHSPVSSLK TERHTPGSPS
1910 1920 1930 1940 1950
GKTDKRPPVP SSGRTEKHPP VSPGKTEKHL PGSPSIRTPE KPAPGSATGK
1960 1970 1980 1990 2000
HEKHLPVSPG KTEKQPPISP TSKTERIEET MSVRELMKAF QSGQDPSKHK
2010 2020 2030 2040 2050
TGLFEHKSAK QKQPQDKSKS RVEKEKGHTV TQRETQRIES QTAKRGQRFQ
2060 2070 2080 2090 2100
VSAATESRRF RSTTITVGLR MEDPVRERFE RTPIIKTPEV VPSVAAEESH
2110 2120 2130 2140 2150
RGSEKIVDEQ GDMDFQISPD RKTSTDFSEV IKQELEDNDK YQQFRLTEDT
2160 2170 2180 2190 2200
EKAQVHLDQV ITSPFNTAFP LDYMKDEFLP ALSLQSGALG GSSESLKQEV
2210 2220 2230 2240 2250
IAGSPCSSLM EGTPQISSEE SYKHEGLAET PETSPESLSF SPKKSEEQIG
2260 2270 2280 2290 2300
EAKETTKVGT PTDIHSEKEL PITNDITDSS QKQGAGVTRG SEPSTEHSQK
2310 2320 2330 2340 2350
EVTQDPHKDV CSKQDGCPES QSVSLASEVF TEKGSCGESQ LPLVSSAFKT
2360 2370 2380 2390 2400
QSESETQESL TPSEVTKPFP PSDASVKTAE GTEPKPQGAI RSPQGLELPL
2410 2420 2430 2440 2450
PNRDSEVLSP MADESLAVSH KDSLEASPVL EDNSSHKTPD SLEPSPLKES
2460 2470 2480 2490 2500
PCRDSLESSP VEPKMKAGIL PSHFPLPAAI AKTDLVAEVA SMRSRLLRDP
2510 2520 2530 2540 2550
DGSAEDDSLE QTSLMESSGK SPLSPDTPSS EEVSYEVTPK PSDSSTPKPA
2560 2570 2580 2590 2600
VIHECAEEDD SENGEKKRFT PEEEMFKMVT KIKTFDELEQ EAKQKRDYKK
2610 2620 2630 2640 2650
EPRQDGSSSA SDPDADYSAE VNDEKQMAGT EGEGEVPVLV TSENRKVSSS
2660 2670 2680 2690 2700
SSESEPELTQ LSKGADSGLL TEPVIRVQPP SPLPSSIDSN SSPEEATQFQ
2710 2720 2730 2740 2750
PIVPKQYTFK MNEEIQEEPA TSEDKDCKSH LAEDSQTHSA DAADGSDGDL
2760 2770 2780 2790 2800
NRETTQPETC DGHGCETVSP SNSATPVSLG VQSPEHKDVD KPLAIDKDSL
2810 2820 2830 2840 2850
AHQDTCENDR EEREFDPSGV ESTQADLPNE SSSLSSRCAI PEGNESAKEI
2860 2870 2880 2890 2900
ASPSSPVKVE VTITDQALES MPEDCPIQDS STTMQTERFA MDVPVSELAE
2910 2920 2930 2940 2950
TDENSDPQII SPYENVPSSS FFSAEPSKIQ TDTCHSTVVH SPEVYSVIIR
2960 2970 2980 2990 3000
SSPEDVVVTN SSNRTVSGEE SHCESHDLET ESEQKSALWA AQSDAPPLAV
3010 3020 3030 3040 3050
APTASDAASV TGEQASKVII TKTDADADSW SEIREDDAAF EARVKEEEQK
3060 3070 3080 3090 3100
IFGLMVDRQS QGTTPDTTPA RTPTEEGTPT SEQNPFLFQE GKLFEMTRSG
3110 3120 3130 3140 3150
AIDMTKRPYA DESLHFFQIG QESNEEAISE DLKEGATGAE PPQTETTSES
3160 3170 3180 3190 3200
LELSEPKEAM DDEGELLPDD VSEEIEDLPA SDANIDSQVI ISASTETPTK
3210 3220 3230 3240 3250
EAVSTAVEEP PTTQRSDSLS TVKQTPRPAV PGPVGQLDFS PVTRSVYSGQ
3260 3270 3280 3290 3300
DDESPESSPE EQKSVIEIPT APVDNVPSAE SKPQIPIRTL PTLVPAPPSA
3310 3320 3330 3340 3350
EDESAFSDDF PSSLDEDSKE GGAKPKSKIP VKAPTQRTEW QPSPTDIPLQ
3360 3370 3380 3390 3400
KTAVPQGQET LSRAPDGRSK SESDASSLDA KTKCPVKARS YIETETESRE
3410 3420 3430 3440 3450
RAEGFESESE DGATKPKLFA SRLPVKSRST SSSGRPGTSP TRESREHFFD
3460 3470 3480 3490 3500
LYRNSIEFFE EISDEASKLV DRLTQSEREQ EPPSDDESSS ALEVSVIESL
3510 3520 3530 3540 3550
PPVDIEHSAP EDIFDTRPIW DESIETMIER IPDENGHDRA EDPQDEQERM
3560 3570 3580 3590 3600
EERLAYIADH LGFSWTELAR ELDFTEEQIH QIRIENPNSL QDQSHALLKY
3610 3620 3630 3640 3650
WLERDGKHAT DTILIECLTK INRMDIVHLL ETNTEPLQER MGRSYAEIEQ
3660 3670 3680 3690 3700
TITLDHSEGF SVLPDELCAA KEKKEQEASK ESESSDHPPM VSEEDISVGY
3710 3720 3730 3740 3750
STFQDCLPKT EGDSPAAALS PQMHQEPVQQ DFSGKTQDQQ EYYVTTPGAE
3760 3770 3780 3790 3800
VEDPQKATAV PDSLCKTPED ISTPPEGTKP CLQTPVTSER GSPIVQEPEE
3810 3820 3830 3840 3850
ASEPKEESSP RKTSLVIVES TDDQSQVFER LDGDAAFQKG DDMPDIPPET
3860 3870 3880 3890 3900
VTEEEYVDEN GHTVVKKVTR KIIRRYVSSD GTEKEEVTMQ GMPQEPVNIE
3910 3920
DGDNYSKVIK RVVLKSDTQQ SEDNNE
Length:3,926
Mass (Da):429,108
Last modified:November 30, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DF67FC08226826C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C8R3ANK2_MOUSE
Ankyrin-2
Ank2 AnkB
3,898Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2R5S4R2R5_MOUSE
Ankyrin-2
Ank2
3,900Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1U2S4R1U2_MOUSE
Ankyrin-2
Ank2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1M4S4R1M4_MOUSE
Ankyrin-2
Ank2
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2T7S4R2T7_MOUSE
Ankyrin-2
Ank2
1,219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2Q9S4R2Q9_MOUSE
Ankyrin-2
Ank2
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRM9A0A087WRM9_MOUSE
Ankyrin-2
Ank2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1I1S4R1I1_MOUSE
Ankyrin-2
Ank2
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1J9S4R1J9_MOUSE
Ankyrin-2
Ank2
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2D6S4R2D6_MOUSE
Ankyrin-2
Ank2
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000182064; ENSMUSP00000138620; ENSMUSG00000032826

UCSC genome browser

More...
UCSCi
uc008rgv.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiS4R2F3
ModBaseiSearch...

PTM databases

SwissPalmiS4R2F3

Proteomic databases

jPOSTiS4R2F3
MaxQBiS4R2F3
PeptideAtlasiS4R2F3
PRIDEiS4R2F3
ProteomicsDBi320594

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26481, 355 antibodies

Genome annotation databases

EnsembliENSMUST00000182064; ENSMUSP00000138620; ENSMUSG00000032826
UCSCiuc008rgv.1, mouse

Organism-specific databases

MGIiMGI:88025, Ank2
VEuPathDBiHostDB:ENSMUSG00000032826

Phylogenomic databases

GeneTreeiENSGT00940000155279

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ank2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032826, Expressed in cerebellum and 256 other tissues

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 3 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4R2F3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S4R2F3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: November 30, 2016
Last modified: September 29, 2021
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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