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Entry version 39 (31 Jul 2019)
Sequence version 1 (18 Sep 2013)
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Protein
Submitted name:

Protein piccolo

Gene

Pclo

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein piccoloImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PcloImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349390 Pclo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
S4R2E0

PRoteomics IDEntifications database

More...
PRIDEi
S4R2E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061601 Expressed in 179 organ(s), highest expression level in cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
S4R2E0 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1153 – 1247PDZInterPro annotationAdd BLAST95
Domaini1365 – 1464C2InterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni212 – 318DisorderedSequence analysisAdd BLAST107
Regioni344 – 384DisorderedSequence analysisAdd BLAST41
Regioni477 – 548DisorderedSequence analysisAdd BLAST72
Regioni911 – 947DisorderedSequence analysisAdd BLAST37
Regioni1001 – 1039DisorderedSequence analysisAdd BLAST39
Regioni1254 – 1280DisorderedSequence analysisAdd BLAST27
Regioni1299 – 1349DisorderedSequence analysisAdd BLAST51
Regioni1475 – 1574DisorderedSequence analysisAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 33Sequence analysisAdd BLAST21
Coiled coili86 – 117Sequence analysisAdd BLAST32
Coiled coili407 – 444Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi212 – 277PolyampholyteSequence analysisAdd BLAST66
Compositional biasi286 – 310PolyampholyteSequence analysisAdd BLAST25
Compositional biasi351 – 365PolarSequence analysisAdd BLAST15
Compositional biasi499 – 548PolarSequence analysisAdd BLAST50
Compositional biasi924 – 947PolarSequence analysisAdd BLAST24
Compositional biasi1256 – 1273PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1310 – 1328PolarSequence analysisAdd BLAST19
Compositional biasi1492 – 1509PolarSequence analysisAdd BLAST18
Compositional biasi1527 – 1564PolarSequence analysisAdd BLAST38

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060 Eukaryota
ENOG410ZNB1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00620000087961

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030629 Piccolo

The PANTHER Classification System

More...
PANTHERi
PTHR14113:SF6 PTHR14113:SF6, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

S4R2E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XESTLLIVPD EDKQQQQLDL ERELLELEKI KQQRFAEELE WERQEIQRFR
60 70 80 90 100
EQEKIMVQKK LEELQSMKQH LLYQQEEERQ AQFMMRQETL AQQQLQLEQI
110 120 130 140 150
QQLQQQLHQQ LEEQKLRQIY QYNYEPSGTA SPQTTTEQAI LEGQYVATEG
160 170 180 190 200
SQFWATEDAT TTASTVVAIE IPQSQGWYTV QSDGVTQYIA PPGILSTVSE
210 220 230 240 250
IPLTDVVVKE EKQPKKRSSG AKVRGQYDEM GESMADDPRN LKKIVDSGVQ
260 270 280 290 300
TDDEETADRT YASRRRRTKK SVDTSVQTDD EDQDEWDMPS RSRRKARTGK
310 320 330 340 350
YGDSTAEGDK TKPPSKVSSV AVQTVAEISV QTEPLGTIRT PSIRARVDAK
360 370 380 390 400
AKGSQTTSGT QKKVKRTLPN PPPEEASTGT QSTYSTMGTA SRRRMCRTNT
410 420 430 440 450
MARAKILQDI DRELDLVERE SAKLRKKQAE LDEEEKEIDA KLRYLEMGIN
460 470 480 490 500
RRKEALLKER EKRERAYLQG VAEDRDYMSD SEVSSTRPSR VESQHGIERP
510 520 530 540 550
RTAPQTEFSQ FIPPQTQTEA QLVPPTSPYT QYQYSSPALP TQAPTPYTQQ
560 570 580 590 600
SHFQQQTLYH QQVSPYQTQP TFQAVATMSF TPQAQPTPTP QPSYQLPSQM
610 620 630 640 650
MVIQQKPRQT TLYLEPKITS TYEVIRNQPL MIAPVSTDNT YAVSHLGSKY
660 670 680 690 700
NSLDLRIGLE ERSSMASSPI SSISADSFYA DIDHHTSRNY VLIDDIGDIT
710 720 730 740 750
KGTAALSSAF SLHEKDLSKT DRLLRTTETR RSQEVTDFLA PLQTSSRLHS
760 770 780 790 800
YVKAEEDSME DPYELKLLKH QIKQEFRRGT ESLDHLAGLS HYYHADTSYR
810 820 830 840 850
HFPKSEKYSI SRLTLEKQAA KQLPAAILYQ KQSKHKKALI DPKMSKFSPI
860 870 880 890 900
QESRDLEPDY PTYLSSSTSS IGGISSRARL LQDDITFGLR KNITDQQKFM
910 920 930 940 950
GSSLGSGLGT LGNTIRSALQ DEADKPYSSG SRSRPSSRPS SVYGLDLSIK
960 970 980 990 1000
RDSSSSSLRL KAQEAEALDV SFGHSSSSAR TKPTSLPISQ SRGRIPIVAQ
1010 1020 1030 1040 1050
NSEEESPLSP VGQPMGMARA AAGPLPPISA DTRDQFGSSH SLPEVQQHMR
1060 1070 1080 1090 1100
EESRTRGYDR DIAFIMDDFQ HAMSDSEVAV AMYDVSLVPK AYHLRREETD
1110 1120 1130 1140 1150
WFDKPRESRL ENGHGLDRKL PERLVHSRPL SQHQEQILQM NGKTMHYIFP
1160 1170 1180 1190 1200
HARIKITRDS KDHTVSGNGL GIRIVGGKEI PGHSGEIGAY IAKILPGGSA
1210 1220 1230 1240 1250
EHSGKLIEGM QVLEWNGIPL TSKTYEEVQS IINQQSGEAE ICVRLDLNML
1260 1270 1280 1290 1300
SDSENPQHLE LHEPPKVVDK AKSPGVDPKQ LAAELQKVSL QQSPLVMSSV
1310 1320 1330 1340 1350
VEKGAHAHSG PTSAGSSSVP SPGQPGSPSV SKKKHGGSKP TDVSKTASHP
1360 1370 1380 1390 1400
ITGEIQLQIN YDLGNLIIHI LQARNLVPRD NNGYSDPFVK VYLLPGRGQV
1410 1420 1430 1440 1450
MVVQNASVEY KRRTKYVQKS LNPEWNQTVI YKSISMEQLM KKTLEVTVWD
1460 1470 1480 1490 1500
YDRFSSNDFL GEVLIDLSST SHLDNTPRWY PLKEQTESIE HGKSHSSQNS
1510 1520 1530 1540 1550
QQSPKPSVIK SRSHGIFPDP SKDMQVPTIE KSHSSPGSSK SSSEGHLRSH
1560 1570 1580 1590
GPSRSQSKTS VAQTHLEDAG AAIAAAEAAV QQLRIQPSKR RK
Length:1,592
Mass (Da):178,465
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10F8790E6241155B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QYX7PCLO_MOUSE
Protein piccolo
Pclo Acz
5,068Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC125043 Genomic DNA No translation available.
AC125533 Genomic DNA No translation available.
AC144480 Genomic DNA No translation available.
AC144625 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000182915; ENSMUSP00000138607; ENSMUSG00000061601

UCSC genome browser

More...
UCSCi
uc008wmj.3 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125043 Genomic DNA No translation available.
AC125533 Genomic DNA No translation available.
AC144480 Genomic DNA No translation available.
AC144625 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

MaxQBiS4R2E0
PRIDEiS4R2E0

Genome annotation databases

EnsembliENSMUST00000182915; ENSMUSP00000138607; ENSMUSG00000061601
UCSCiuc008wmj.3 mouse

Organism-specific databases

MGIiMGI:1349390 Pclo

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
ENOG410ZNB1 LUCA
GeneTreeiENSGT00620000087961

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pclo mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061601 Expressed in 179 organ(s), highest expression level in cingulate cortex
ExpressionAtlasiS4R2E0 baseline and differential

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030629 Piccolo
PANTHERiPTHR14113:SF6 PTHR14113:SF6, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4R2E0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S4R2E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: July 31, 2019
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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