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Entry version 35 (31 Jul 2019)
Sequence version 1 (18 Sep 2013)
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Protein
Submitted name:

Protein PRRC2C

Gene

Prrc2c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein PRRC2CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prrc2cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913754 Prrc2c

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
S4R209

MaxQB - The MaxQuant DataBase

More...
MaxQBi
S4R209

PeptideAtlas

More...
PeptideAtlasi
S4R209

PRoteomics IDEntifications database

More...
PRIDEi
S4R209

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040225 Expressed in 249 organ(s), highest expression level in dorsal pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
S4R209 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 335DisorderedSequence analysisAdd BLAST335
Regioni358 – 458DisorderedSequence analysisAdd BLAST101
Regioni478 – 519DisorderedSequence analysisAdd BLAST42
Regioni582 – 654DisorderedSequence analysisAdd BLAST73
Regioni676 – 712DisorderedSequence analysisAdd BLAST37
Regioni741 – 824DisorderedSequence analysisAdd BLAST84
Regioni925 – 965DisorderedSequence analysisAdd BLAST41
Regioni985 – 1009DisorderedSequence analysisAdd BLAST25
Regioni1338 – 1375DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 45PolyampholyteSequence analysisAdd BLAST45
Compositional biasi71 – 137PolyampholyteSequence analysisAdd BLAST67
Compositional biasi139 – 157PolarSequence analysisAdd BLAST19
Compositional biasi165 – 187PolarSequence analysisAdd BLAST23
Compositional biasi189 – 208PolyampholyteSequence analysisAdd BLAST20
Compositional biasi234 – 254PolarSequence analysisAdd BLAST21
Compositional biasi286 – 305PolarSequence analysisAdd BLAST20
Compositional biasi311 – 334PolyampholyteSequence analysisAdd BLAST24
Compositional biasi373 – 396PolyampholyteSequence analysisAdd BLAST24
Compositional biasi403 – 436PolarSequence analysisAdd BLAST34
Compositional biasi485 – 519PolarSequence analysisAdd BLAST35
Compositional biasi588 – 609PolarSequence analysisAdd BLAST22
Compositional biasi610 – 624Pro-richSequence analysisAdd BLAST15
Compositional biasi625 – 654PolarSequence analysisAdd BLAST30
Compositional biasi690 – 712PolarSequence analysisAdd BLAST23
Compositional biasi745 – 759PolyampholyteSequence analysisAdd BLAST15
Compositional biasi772 – 804PolyampholyteSequence analysisAdd BLAST33
Compositional biasi932 – 965PolarSequence analysisAdd BLAST34
Compositional biasi1350 – 1375PolarSequence analysisAdd BLAST26

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4817 Eukaryota
ENOG4111VEG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183161

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033184 PRRC2

The PANTHER Classification System

More...
PANTHERi
PTHR14038 PTHR14038, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

S4R209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RIDNRPLEKP YIREEDKSKP GFLPKGEPTR RGRGGTFRRG GRDPGGRPSR
60 70 80 90 100
PATLRRPAYR DNQWNTRQAE PPKPEDGEPP RRHEQFMPIP ADKRPPKFER
110 120 130 140 150
KFDPARERPR RQRPTRPPRQ DKPPRFRRLR EREAASKTSE VLVPSNGTAN
160 170 180 190 200
NVVQEPVNPP ADISGNKTPD LSNQNSSDQA NEEWETASES SDFNERRERD
210 220 230 240 250
EKKNADKSSQ AVVKAGESVL PPKREIAKRS FSSQRPGVDR QNRRGNNGPP
260 270 280 290 300
KSGRNFSGPR NERRNGPPSK GGKRGPFDDQ ASGTAGADPV SGNSAHHQEG
310 320 330 340 350
VPNGAGQKNS KDAAGKKRED TKPGPKKPKE KVDALSQFDL NNYASVVIID
360 370 380 390 400
DHPEVTVIED PQSNLNDDGF TEVVSKKQQK RLQDEERRKK EEQVVQVWSK
410 420 430 440 450
KNIGEKGRSQ TSKLPPRFAK KQATGTQQIQ APPSAPVPVS SSAPGLTAPA
460 470 480 490 500
AAAPASTPAP VPILASATAL VPVSTPAPVL TSCPAPVPTS ASAPVPASTS
510 520 530 540 550
SPVTASSSSQ PSVPAPTPVL ASASTTVSVP ILTSASIPIL ASALAPATVS
560 570 580 590 600
SPTPVVSATA VPSISTPAVP ASAPTASVPL APASAASTVP PPASTVQTQT
610 620 630 640 650
QTQTHKPVQS PLPPSAPSSK QPPPSIRLPS AQTSNGTDFV AAGKSMPTSQ
660 670 680 690 700
SHGSLTAELW DSKVAAPAVL NDISKKLGPI SPPQPPSVSA WNKPLTSFGS
710 720 730 740 750
ATSSEGTRNG QESGVEIGID TIQFGAPASN GNENEVVPVL SEKATDKVPE
760 770 780 790 800
PKEQRQKQPR AGPIKAQKLP DLSLVENKEH KPGPIGKERS LKNRKVKDAQ
810 820 830 840 850
QVEPEGQEKP SPAVVRSTDP ETAKETKAVS EMSAEIGAMI SVSSAEYGSD
860 870 880 890 900
AKESVTDYTT PSSSLPNTVA TNNAKMEDTL VNNVPLPNTL PLPKRETIQQ
910 920 930 940 950
SSSLTSVPPT TFSLTFKMES ARKAWENSPN LREKGSPVTS TAPPIVSGVS
960 970 980 990 1000
SSASGPSTAN YSSFSSASMP QIPVASVTPT ASLSGAGTYT TSSLSTKSTT
1010 1020 1030 1040 1050
TSDPPNICKV KPQQLQTSSL PSASHFSQLS CMPSLIAQQQ QSPQVYVSQS
1060 1070 1080 1090 1100
AAAQIPAFYM DTSHLFNTQH ARLAPPSLAQ QQGFQPGLSQ PTSVQQIPIP
1110 1120 1130 1140 1150
IYAPLQGQHQ AQLSLGAGPA VSQAQELFSS SIQPYRSQPA FMQSSLSQPS
1160 1170 1180 1190 1200
VVLSGTAIHN FPAVQHQELA KAQSGLAFQQ TSNPQPIPIL YDHQLGQASG
1210 1220 1230 1240 1250
LGSSQLIDTH LLQARANLTQ ASNLYSGQVQ QPGQTNFYNT AQSPSALQQV
1260 1270 1280 1290 1300
NYGMVTVPLP ASQLSLTNFG STGQPLIALP QTLQPQLQHT TPQAQAQSLS
1310 1320 1330 1340 1350
RPAQVSQPFR GLIPAGTQHS MMATTGKMSE MELKAFGSGI DIKPGTPPIG
1360 1370 1380 1390 1400
GRSTTPTSSP FRATSTSPNS QSSKMNSVVY QKQFQSAPAT VRMAQPFPAQ
1410 1420 1430 1440 1450
FAPQILSQPN LVPPLVRAPH TNTFPAPVQR PPMALASQMP PPLTTGLMSH
1460 1470 1480 1490 1500
ARLPHVARGP CGSLSGVRGN QAQAALKAEQ DLKKRAVGRG LSHKTFGPRC
1510
KAESRGSSVH AAVLL
Length:1,515
Mass (Da):160,365
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CF2DA854836C5C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TLH4PRC2C_MOUSE
Protein PRRC2C
Prrc2c Bat2d, Bat2d1, Bat2l2, Kiaa1096
2,846Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R294S4R294_MOUSE
Protein PRRC2C
Prrc2c
2,724Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J9S4R2J9_MOUSE
Protein PRRC2C
Prrc2c
2,765Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQ79A0A0A0MQ79_MOUSE
Protein PRRC2C
Prrc2c
2,844Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R298S4R298_MOUSE
Protein PRRC2C
Prrc2c
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2E2S4R2E2_MOUSE
Protein PRRC2C
Prrc2c
564Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2L9S4R2L9_MOUSE
Protein PRRC2C
Prrc2c
1,276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC118643 Genomic DNA No translation available.
AC132867 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000182393; ENSMUSP00000138451; ENSMUSG00000040225

UCSC genome browser

More...
UCSCi
uc007dgp.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118643 Genomic DNA No translation available.
AC132867 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiS4R209
MaxQBiS4R209
PeptideAtlasiS4R209
PRIDEiS4R209

Genome annotation databases

EnsembliENSMUST00000182393; ENSMUSP00000138451; ENSMUSG00000040225
UCSCiuc007dgp.1 mouse

Organism-specific databases

MGIiMGI:1913754 Prrc2c

Phylogenomic databases

eggNOGiKOG4817 Eukaryota
ENOG4111VEG LUCA
GeneTreeiENSGT00950000183161

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Prrc2c mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040225 Expressed in 249 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiS4R209 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033184 PRRC2
PANTHERiPTHR14038 PTHR14038, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4R209_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S4R209
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: July 31, 2019
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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