Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione-regulated potassium-efflux system protein KefC

Gene

kefC

Organism
Escherichia coli KTE38
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K+/H+ antiport.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiportUniRule annotationSAAS annotation, Ion transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-regulated potassium-efflux system protein KefCUniRule annotation
Alternative name(s):
K(+)/H(+) antiporterUniRule annotation
Gene namesi
Name:kefCUniRule annotation
ORF Names:WG7_00161Imported
OrganismiEscherichia coli KTE38Imported
Taxonomic identifieri1169355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000014196 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalUniRule annotationAdd BLAST19
Transmembranei31 – 49HelicalUniRule annotationAdd BLAST19
Transmembranei55 – 72HelicalUniRule annotationAdd BLAST18
Transmembranei84 – 111HelicalUniRule annotationAdd BLAST28
Transmembranei117 – 135HelicalUniRule annotationAdd BLAST19
Transmembranei147 – 169HelicalUniRule annotationAdd BLAST23
Transmembranei181 – 202HelicalUniRule annotationAdd BLAST22
Transmembranei214 – 233HelicalUniRule annotationAdd BLAST20
Transmembranei239 – 258HelicalUniRule annotationAdd BLAST20
Transmembranei270 – 290HelicalUniRule annotationAdd BLAST21
Transmembranei296 – 315HelicalUniRule annotationAdd BLAST20
Transmembranei327 – 348HelicalUniRule annotationAdd BLAST22
Transmembranei360 – 378HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotationSAAS annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homodimer. Interacts with the regulatory subunit KefF.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini401 – 523RCK N-terminalInterPro annotationAdd BLAST123

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili378 – 398Sequence analysisAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
HAMAPiMF_01413 K_H_efflux_KefC, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR004771 K/H_exchanger
IPR023941 K_H_efflux_KefC
IPR006036 K_uptake_TrkA
IPR038770 Na+/solute_symporter_sf
IPR036291 NAD(P)-bd_dom_sf
IPR003148 RCK_N
PANTHERiPTHR16254:SF28 PTHR16254:SF28, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF02254 TrkA_N, 1 hit
PRINTSiPR00335 KUPTAKETRKA
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00932 2a37, 1 hit
PROSITEiView protein in PROSITE
PS51201 RCK_N, 1 hit

Sequencei

Sequence statusi: Complete.

S0ZRL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSHTLIQAL IYLGSAALIV PIAVRLGLGS VLGYLIAGCI IGPWGLRLVT
60 70 80 90 100
DAESILHFAE IGVVLMLFII GLELDPQRLW KLRAAVFGGG ALQMVICGGL
110 120 130 140 150
LGLFCMLLGL RWQVAELIGM TLALSSTAIA MQAMNERNLM VTQMGRSAFA
160 170 180 190 200
VLLFQDIAAI PLVAMIPLLA ASSASTTMGA FALSALKVAG ALVLVVLLGR
210 220 230 240 250
YVTRPALRFV ARSGLREVFS AVALFLVFGF GLLLEEVGLS MAMGAFLAGV
260 270 280 290 300
LLASSEYRHA LESDIEPFKG LLLGLFFIGV GMSIDFGTLL ENPLRIVILL
310 320 330 340 350
LGFLIIKIAM LWLIARPLQV PNKQRRWFAV LLGQGSEFAF VVFGAAQMAN
360 370 380 390 400
VLEPEWAKSL PLAVALSMAA TPILLVILNR LEQSSTEEAR EADEIDEEQP
410 420 430 440 450
RVIIAGFGRF GQITGRLLLS SGVKMVVLDH DPDHIETLRK FGMKVFYGDA
460 470 480 490 500
TRMDLLESAG AAKAEVLINA IDDPQTNLQL TEMVKEHFPH LQIIARARDV
510 520 530 540 550
DHYIRLRQAG VEKPERETFE GALKTGRLAL ESLGLGPYEA RERADVFRRF
560 570 580 590 600
NIQMVEEMAM VENDTKARAA VYKRTSAMLS EIITEDREHL SLIQRHGWQG
610 620
TEEGKHTGNM ADEPETKPSS
Length:620
Mass (Da):67,716
Last modified:September 18, 2013 - v1
Checksum:i8E177F2A135D9762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ASUD01000005 Genomic DNA Translation: EOV15452.1
RefSeqiWP_016235816.1, NZ_KE136792.1

Genome annotation databases

EnsemblBacteriaiEOV15452; EOV15452; WG7_00161
PATRICifig|1169355.3.peg.171

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ASUD01000005 Genomic DNA Translation: EOV15452.1
RefSeqiWP_016235816.1, NZ_KE136792.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEOV15452; EOV15452; WG7_00161
PATRICifig|1169355.3.peg.171

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
HAMAPiMF_01413 K_H_efflux_KefC, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR004771 K/H_exchanger
IPR023941 K_H_efflux_KefC
IPR006036 K_uptake_TrkA
IPR038770 Na+/solute_symporter_sf
IPR036291 NAD(P)-bd_dom_sf
IPR003148 RCK_N
PANTHERiPTHR16254:SF28 PTHR16254:SF28, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF02254 TrkA_N, 1 hit
PRINTSiPR00335 KUPTAKETRKA
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00932 2a37, 1 hit
PROSITEiView protein in PROSITE
PS51201 RCK_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS0ZRL7_ECOLX
AccessioniPrimary (citable) accession number: S0ZRL7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again