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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Escherichia coli KTE38
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 40C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi120 – 127ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation, Hydrolase, ProteaseImported
LigandATP-bindingUniRule annotationSAAS annotationImported, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotationSAAS annotation
Gene namesi
Name:clpXUniRule annotation
ORF Names:WG7_00545Imported
OrganismiEscherichia coli KTE38Imported
Taxonomic identifieri1169355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000014196 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotationSAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliS0ZAM8
SMRiS0ZAM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 51zf-C4_ClpXInterPro annotationAdd BLAST40
Domaini111 – 333AAAInterPro annotationAdd BLAST223
Domaini317 – 412ClpB_D2-smallInterPro annotationAdd BLAST96

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotationSAAS annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 40C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

OMAiDIMYDLP

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175 ClpX, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004487 Clp_protease_ATP-bd_su_ClpX
IPR027417 P-loop_NTPase
IPR010603 Znf_CppX_C4
IPR038366 Znf_CppX_C4_sf
PANTHERiPTHR11262 PTHR11262, 2 hits
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
PF06689 zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SM00994 zf-C4_ClpX, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00382 clpX, 1 hit

Sequencei

Sequence statusi: Complete.

S0ZAM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKRKDGSG KLLYCSFCGK SQHEVRKLIA GPSVYICDEC VDLCNDIIRE
60 70 80 90 100
EIKEVAPHRE RSALPTPHEI RNHLDDYVIG QEQAKKVLAV AVYNHYKRLR
110 120 130 140 150
NGDTSNGVEL GKSNILLIGP TGSGKTLLAE TLARLLDVPF TMADATTLTE
160 170 180 190 200
AGYVGEDVEN IIQKLLQKCD YDVQKAQRGI VYIDEIDKIS RKSDNPSITR
210 220 230 240 250
DVSGEGVQQA LLKLIEGTVA AVPPQGGRKH PQQEFLQVDT SKILFICGGA
260 270 280 290 300
FAGLDKVISH RVETGSGIGF GATVKAKSDK ASEGELLAQV EPEDLIKFGL
310 320 330 340 350
IPEFIGRLPV VATLNELSEE ALIQILKEPK NALTKQYQAL FNLEGVDLEF
360 370 380 390 400
RDEALDAIAK KAMARKTGAR GLRSIVEAAL LDTMYDLPSM EDVEKVVIDE
410 420
SVIDGQSKPL LIYGKPEAQQ ASGE
Length:424
Mass (Da):46,356
Last modified:September 18, 2013 - v1
Checksum:i9DEF1B0786E42B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ASUD01000016 Genomic DNA Translation: EOV13974.1
RefSeqiWP_000130305.1, NZ_KE136812.1

Genome annotation databases

EnsemblBacteriaiEOV13974; EOV13974; WG7_00545
PATRICifig|1169355.3.peg.577

Similar proteinsi

Entry informationi

Entry nameiS0ZAM8_ECOLX
AccessioniPrimary (citable) accession number: S0ZAM8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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