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Entry version 36 (18 Sep 2019)
Sequence version 1 (18 Sep 2013)
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Protein

Fusarin C synthetase

Gene

FUS1

Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fusarin C synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:22865073,PubMed:23932525). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (PubMed:23932525). The roles of the other FUS members are yet undetermined (PubMed:23932525). The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure (PubMed:23932525). The cytochrome P450 monooxygenase FUS8 participates in multiple oxidation processes at carbon C-20 and is able to use the FUS1 product as substrate, resulting in formation of 20-hydroxy-prefusarin (PubMed:23932525). This reaction seems to be essential before the 2-pyrrolidone ring closure can be catalyzed by FUS2, generating 20-hydroxy-fusarin (PubMed:23932525). FUS8 is able to further oxidizes carbon C-20 after ring closure, resulting in the formation of carboxy-fusarin C (PubMed:23932525). As the last step, FUS9 methylates the hydroxyl group at C-21 to generate fusarin C (PubMed:23932525). Fusarin C can then rearrange to epi-fusarin C, the (z)-isomers, and fusarin A and fusarin D (PubMed:23932525).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Methyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-19357

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fusarin C synthetaseBy similarity (EC:2.3.1.-1 Publication)
Short name:
FUSSBy similarity
Alternative name(s):
Fusarin C cluster PKS/NRPS FUS11 Publication
Fusarin biosynthesis megasynthetaseBy similarity
Fusarin biosynthesis protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUS11 Publication
Synonyms:fusA1 Publication
ORF Names:FFUJ_10058
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1279085 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000016800 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs the production of fusarin C (PubMed:22865073, PubMed:23932525).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004373551 – 3916Fusarin C synthetaseAdd BLAST3916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2409O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3530O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expressed under high amounts of nitrogen via regulation by GLN1 (PubMed:22865073, PubMed:23932525). Moreover, components of the fungal-specific velvet complex VEL1, VEL2 and LAE1 act also as positive regulators of expression (PubMed:20572938, PubMed:23932525). Finally, expression is induced under acidic conditions in a PACC-independent manner (PubMed:23932525).3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
S0EEY3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2372 – 2449Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini3493 – 3570Carrier 2PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 443Ketosynthase (KS) domainSequence analysisAdd BLAST432
Regioni548 – 866Malonyl-CoA:ACP transacylase (MAT) domainSequence analysisAdd BLAST319
Regioni935 – 1228Dehydrogenase (DH) domainSequence analysisAdd BLAST294
Regioni1347 – 1575C-methyltransferase (CMeT) domainSequence analysisAdd BLAST229
Regioni2092 – 2266Ketoreductase (KR) domain 1Sequence analysisAdd BLAST175
Regioni2522 – 2806CondensationSequence analysisAdd BLAST285
Regioni2975 – 3385AdenylationSequence analysisAdd BLAST411
Regioni3612 – 3833Thiolester reductase (R) domainSequence analysisAdd BLAST222

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

FUS1 is an unusual polyketide synthase (PKS) fused to a non-ribosomal peptide synthetase (NRPS) module to form a megasynthetase.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.10.129.110, 1 hit
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S0EEY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGNQYLPKE PIAIIGTSCR FPGGANTPSK LWDLLCEKRD VQSRIPNDRF
60 70 80 90 100
NVDAFYSTNG DKNGCTDVKN AYVLSEDIRV FDASFFKINP REAEAMDPQQ
110 120 130 140 150
RLLLEAVYEA TEAAGLPMED LKGSDTAVYV GCMTGDYHEM LMRDPQDMPK
160 170 180 190 200
YMATGTARSI LSNRISYLFD WKGPSMTIDT ACSSSLVAVY DAVTALRNGV
210 220 230 240 250
SKIACAGGAN LILGPEMMIS ESKLHMLSPT GRSRMWDASA NGYARGEGVA
260 270 280 290 300
AIMMKTLSQA LADGDHIQGV IREIGVNSDG RTNGITLPSP EAQKVLIRQT
310 320 330 340 350
YKKAGLDFFK DRCQFFEAHG TGTPAGDPLE ARAIHEAFFT DGDTVPEPMY
360 370 380 390 400
VGSVKTAIGH LEGCAGLAGL IKALEAVKRG IIPPNQLFEN LNPALKPYVS
410 420 430 440 450
NLRLPTESKP WPKLTPGSPR RASVNSFGFG GTNVHAIIEQ FDNVHTQTSS
460 470 480 490 500
SDGIISTPLV LSANSDLSLR KQIAHFAEAI EHNDKGKIDR VIFTLTQRRS
510 520 530 540 550
QLPLRTYFSG YDLQSLQQKL RDATAENAVL PFISQTVPPG RPPRILGVFT
560 570 580 590 600
GQGAQWPTMG REILKASPFA RAVIASLEES LASLAQPPAW TLTEQIMADK
610 620 630 640 650
ESSRLSEAAI SQPLCTAVQI MVVELLRKAG ITFNCVIGHS SGEITAAYTA
660 670 680 690 700
GFLSASDAIR VAYLRGVCAK LAGGENGETG SMIAVGLSYE EASAFCEENF
710 720 730 740 750
AGLVDVAASN APTSTTLSGD KASIDDAKAL LDAQGTFARI LKVDTAYHSH
760 770 780 790 800
HMNPCAQPYL DKLQAARVKS LPGDESVEWY SSVLGERITA SLHGEALCDE
810 820 830 840 850
YWVENMVNPV LFSVASELVA EASLPCHVAL EVGPHPALKG PFNQTYKRAT
860 870 880 890 900
GSPLPYQGTV ARNIHDVEGL SDSLGFLWSH LGKSAVDFTA YSQAFSPSIT
910 920 930 940 950
AMADGLPPYA WDHTQSFWRE SRKSLNYRQR TQPPHPLLGA RSVEDTADSM
960 970 980 990 1000
RWINYLRLDD VPWLEGHKVE GQVVYPAAGY LVMAMEAARA IDTTKGIQLI
1010 1020 1030 1040 1050
ELSDVYILSA IQLTEGSQAL ETVFTLQVER NEPTFSTASW TLSTPMSGRN
1060 1070 1080 1090 1100
DSWKCNAKGQ LRVEFGCSDD AARLPSRNKP IASLTSVNME RFYSALANIG
1110 1120 1130 1140 1150
LEYTGEFKQL KSIDRQLGLA TAHVSQVVPD FPAMIHPALL DGAFQSIFAA
1160 1170 1180 1190 1200
YCWPDDGSLQ APFVPTFFRS LRIANTGHLR HGEDLVVDSF LTNTNERELT
1210 1220 1230 1240 1250
ADMDVFQSSQ GQPVLQLQGL TCTSLLRPGP SNAKELYTKT EWEVDIASGI
1260 1270 1280 1290 1300
AQSDTQDQDT ASDLELVDLC ERLSYFYLRE LNNAVGREEV SGFDWHYRRI
1310 1320 1330 1340 1350
FEWIDHLFPL IQSGQHATIK TEWSSDSRDW LMQQSARFPG RIDLQLIQAV
1360 1370 1380 1390 1400
GENLPSVVRK QTTMLEHMVK DDMLNRIYKF GLGFERANVY LGRISKQIAH
1410 1420 1430 1440 1450
RYPRMNILEI GAGTGGATKG IMESLGTTFE TYTFTDISTG FFEAAAEAFD
1460 1470 1480 1490 1500
HWADKMIFKP LNIESDPTEQ GFPEGHYDFI IASNVLHATK SLTVTMRNTR
1510 1520 1530 1540 1550
KLLKPGGQLL LLEVTSDIVR VKLMMSGLSG WWLGGDDGRR YGPTIPVSQW
1560 1570 1580 1590 1600
DALLKQTGFS GVDKTVNDFV DAEKYMTSVM LSQAVDDRIE LLRQPRLTFS
1610 1620 1630 1640 1650
DWLSSQSITV VGGYFRDIGR DILEILHQMN HGASQPVIHH VGSFEELALS
1660 1670 1680 1690 1700
NIQARSALVL EDLDEPILKD LTDDKLRGVQ RLINESRQVL WVSKGCQRDE
1710 1720 1730 1740 1750
PFANMSIGMC RSLASEYPHI HLQHVDIEGR VSPMTASLLV EAFLRLVYRA
1760 1770 1780 1790 1800
SLKSDDLVWS IEAELVLRED KWFIPRVKSD EALNNQLNAS KMTIHSQKTL
1810 1820 1830 1840 1850
HGDTIEIQQR SNQFVIVDPV PCVPVSVSSP PVAITVTHSL LFPFQVGTKS
1860 1870 1880 1890 1900
SGYLCYGYTD SQPRTRVLAI SEVNRSKVSV SPFSVWDLSS SEIDAADLLR
1910 1920 1930 1940 1950
KTALAITADR LLSDFEAGAT VLIHESDELL GAALQWKAAE LDLNVIMTTS
1960 1970 1980 1990 2000
ESSRERSTGA MFIHALAPER LVNHIMPQHT KAVIDLSGKD YSIVGSPLRR
2010 2020 2030 2040 2050
CLPANCKFHQ LQDILGNASQ GVADPIIHGV RDASRSSLQL CGDGPVVKLS
2060 2070 2080 2090 2100
DLPSLRASIK DYATVVEFSA NTTIPAIVQP LEGSRLFRSD RTYLLIGCTG
2110 2120 2130 2140 2150
GLGKALCRWM VSCGVRHLAL TTRNVAAIDQ VWLEELRIQG AQVNLYQADV
2160 2170 2180 2190 2200
SDKAALLQAY DQIVKEMPPI CGTANAALLL SDRTFTELKV NDFTKVFGPK
2210 2220 2230 2240 2250
VKGTQNLHEL LLDQKLDFFI MFSSLASVVG NRGQANYAAS NLFMSAIAEQ
2260 2270 2280 2290 2300
RRAKGLAASV MHIGMVLGVG YVSSTGAYEA TLRSSNYMAI SETDLLNMFS
2310 2320 2330 2340 2350
QAILVGQPNS THAPELITGL NRFSLEPEAQ KYFWRDNMRF CHHTLEEEHQ
2360 2370 2380 2390 2400
ERASATKVSI SQRLSEAKGT AEILAVVEEE FCTKLERLLQ AEAGFVKTSQ
2410 2420 2430 2440 2450
SLLGLGVDSL VAAEIRSWFL KELEVDTPVL EILNTASITE LCSTVVSHLP
2460 2470 2480 2490 2500
TISGEIAPKT EVTKQAIKTL NVVETSTAVS SALPTENEPF TIRNSPNSTQ
2510 2520 2530 2540 2550
VTSEAGVDED TSIHSKFDRA GPLSFAQERL WFLQQFLRDH STYNVTMHYH
2560 2570 2580 2590 2600
ISGPLRLHDL EMAFQQLIHR HESLRTSFFI DPDTDLPTQA VLKDSSFKLE
2610 2620 2630 2640 2650
QKHNSTAKIE YKAMQEMSYD LENGKVTKAV ILPDSDGEFD LIFGFHHIAL
2660 2670 2680 2690 2700
DGYSAQIMVR DLAIAYAGQT LPSKQQDYLD FAIAQKTAKV PDTTLAYWRS
2710 2720 2730 2740 2750
EFRELPPTLS VFDFAETKTR TPLTDYTTRA LERTISIDQG RSIKAVAKCL
2760 2770 2780 2790 2800
DATPFHIHLA ALQVVLSDLA STKDLCIGIT DANKYDVTHI DTVGFFVNLL
2810 2820 2830 2840 2850
PLRLKISLSQ TLAEVVANAK SKANSALSHS DIPFDVLLDE VKLPRSTTHS
2860 2870 2880 2890 2900
PLFQVILNYK MGSTQKVPLA DCQAQLVAFK DASNPYDLTF DIETYHDGSA
2910 2920 2930 2940 2950
CISVKTQEYL YSESELSFIL DSYLQTLALF ASEPSRTIDQ ICRPTAEQID
2960 2970 2980 2990 3000
KALTLGRGER IPSPRLETLC HYFEEFVVKQ PDDTALVTDK GQALTWCQLK
3010 3020 3030 3040 3050
ALVNQIAMTF VEAGAKQDSR VGVYCEPSMY ILPTLLAIAE VGGVYVPLDA
3060 3070 3080 3090 3100
QNPIKRLQLM VDDCQPDVIL IDDSTATTAR ELETNAIVIN VNTIKADPSN
3110 3120 3130 3140 3150
TFHMDIRARG NGMGYIFYTS GTTGVPKAVA LTHTSLVHHF DGFIHYNNLS
3160 3170 3180 3190 3200
KCRMLQQAPL GFDMSLTQMT LAIMLGGTLI VASSETRKDP MQLAQLMLAE
3210 3220 3230 3240 3250
KVTHTFMTPT LALSVIHHGY EYLRQCVNWE HASLAGEAMT TRVTREFKRL
3260 3270 3280 3290 3300
GLRNLELLNG YGPTEITIIA TCGSNELGDT LRDTHNPSIG RALPNYSCYI
3310 3320 3330 3340 3350
LDENMQPVRP GLAGELVIGG AGVAIGYLNR QDLTEVKFLR DPFSPAEDIA
3360 3370 3380 3390 3400
RGWTRMYRTG DKARFLSDGR LCFLGRIAGD SQIKLRGFRI ELEDIASTIV
3410 3420 3430 3440 3450
RASDGKIPEA AVSLRGEGDS AYLVAFVILS QFNSPSDENG YLKQLLEELS
3460 3470 3480 3490 3500
LPRYMKPARI ISIDQLPMNA SGKLDQYALD ALPVPHEEDI VDKPLTETQE
3510 3520 3530 3540 3550
RLKLGWLKAL PFIDAAIGPD TDFFSAGGNS LRIVSLREYI TREFGVTVSV
3560 3570 3580 3590 3600
FDLFQASTLG EMAAKIDGST TQGPTTMPID WNEETRIDAD LSIVGAQEPL
3610 3620 3630 3640 3650
PSETANDLQV ALTGATGFLG VSILKTLLED KRVSKVHCLA VRSSSNTSDP
3660 3670 3680 3690 3700
VFSSSRVACY PGDLSLPRLG LSQEQFDQLA KTVERIIHNG ADVSFLKTYQ
3710 3720 3730 3740 3750
SLKRSNVSSS RELARMAITR RIPVHFVSTG GVVQLTGQDG LDEVSVADSV
3760 3770 3780 3790 3800
PPTDGSLGYV ASKWASEVIL EKYASQYNLP VWIHRPSNIT GPNAPKADLM
3810 3820 3830 3840 3850
QNIFHYSVKT ASLPDLASWS GCFDFVPVDV VAAGIAGSIY ETQDTVAYKH
3860 3870 3880 3890 3900
HCGREKISVE DLPSYLEAKH GKIETISVEE WLERSKAAGF DEVTAALVEK
3910
TLSRGGIVPW LRKEAN
Length:3,916
Mass (Da):431,028
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i983533C58D311E9D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AFP73394 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JX308619 Genomic DNA Translation: AFP73394.1 Sequence problems.
HF679031 Genomic DNA Translation: CCT73260.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
AFP73394; AFP73394; AFP73394
CCT73260; CCT73260; FFUJ_10058

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX308619 Genomic DNA Translation: AFP73394.1 Sequence problems.
HF679031 Genomic DNA Translation: CCT73260.1

3D structure databases

SMRiS0EEY3
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiAFP73394; AFP73394; AFP73394
CCT73260; CCT73260; FFUJ_10058

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19357

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.10.129.110, 1 hit
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
TIGRFAMsiTIGR01733 AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUS1_GIBF5
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S0EEY3
Secondary accession number(s): J7GLW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: September 18, 2013
Last modified: September 18, 2019
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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