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Entry version 30 (08 May 2019)
Sequence version 1 (18 Sep 2013)
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Protein

Apicidin F synthase

Gene

apf1

Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475). L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475). The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475). Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475). L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475). L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475). The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475). The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475). Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475). The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475). The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8). The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-19327

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apicidin F synthaseCurated (EC:6.3.2.-1 Publication)
Alternative name(s):
Apicidin F synthesis protein 11 Publication
Non-ribosomal peptide synthetase apf11 Publication
Short name:
NRPS apf11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apf11 Publication
ORF Names:FFUJ_00003
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1279085 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000016800 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Apicidin F, like the other known apicidins, is a cyclic tetrapeptides with anti-malarial properties via histone deacetylase inhibitory activity (PubMed:24195442).1 Publication

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to the loss of apicidin F production (PubMed:25058475).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004371561 – 5084Apicidin F synthaseAdd BLAST5084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei768O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2376O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3500O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4592O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by the apicidin F cluster-specific transcription factor apf2 that binds to the eight-base-pair motif 5'-TGACGTGA-3' called the 'Api-box' that is found in all promoters of the apicidin F cluster except in the promoter region of apf2 itself (PubMed:25058475).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
S0DLP2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini731 – 808Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini2341 – 2415Carrier 2PROSITE-ProRule annotationAdd BLAST75
Domaini3463 – 3539Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4554 – 4631Carrier 4PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 606Adenylation 1Sequence analysisAdd BLAST398
Regioni822 – 1124Condensation 1Sequence analysisAdd BLAST303
Regioni1309 – 1609Condensation 2Sequence analysisAdd BLAST301
Regioni1788 – 2192Adenylation 2Sequence analysisAdd BLAST405
Regioni2478 – 2755Condensation 3Sequence analysisAdd BLAST278
Regioni2935 – 3328Adenylation 3Sequence analysisAdd BLAST394
Regioni3581 – 3866Condensation 4Sequence analysisAdd BLAST286
Regioni4029 – 4426Adenylation 4Sequence analysisAdd BLAST398
Regioni4669 – 4948Condensation 5Sequence analysisAdd BLAST280

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47336 SSF47336, 4 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S0DLP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIKMIDKQV LACNLDAFAG RVTNSTDINE QAIEWLSPTP SAVTLEAAWC
60 70 80 90 100
VTLRLYTGLD HLSFGSLTQD GIVATKLCNL GPHDTLEDVC SHVQLYDYSD
110 120 130 140 150
DTVCHYNTAV IFKLDENEGK KLSELIPRGI DVALMVTGSN LGVLARASFM
160 170 180 190 200
DADEARNLCQ NFRHVLNCFQ EPNQAVRGIT LSDNDVNQIL SWNKSQLTRT
210 220 230 240 250
ESLIHDQFAR ILQRQPDKSA IESWDGNMTY RELDAASSSL AESLSRANIG
260 270 280 290 300
PGSWVLFCFN KSRWAIVSML AILKAGGACV PLDPRHPKSR VVQILQATGA
310 320 330 340 350
QHILVGDADN DIKNRLCNEF PSVKVIGVPH HEVCESQDID TISLSFDSPA
360 370 380 390 400
IGLFTSGSTG TPKGIVATHA TICTGASSYA HHIGADDKTR VLQFASYTFD
410 420 430 440 450
VCMVDVFTAL LHGGTLCIPS EEERMTGLQE YISRTQPNWA ALTPTVARVL
460 470 480 490 500
DPALSSKSIR KILLVGEMVR ESDIAEWLDS GVQVYNVYGP AENNLITTAA
510 520 530 540 550
KAIRGRASNV GTGINTHTWV ADVENERLVP IGAVGELICS GPHLTPGYLN
560 570 580 590 600
DPERTASSFF EDLSWIPNMM DNKPFSRRFY RSGDLVRYCA DGSLQCVGRL
610 620 630 640 650
DSQVKLGGQR VELSEIESYI KSHNAAVLVP KAGSMKNKLI AVLEGAGSSG
660 670 680 690 700
QSLGISSCDP GVAQQVEQVL RKNLPSYMCP SIWISVPHLP LSSSGKLDRK
710 720 730 740 750
VLMNKLETLS HEEYLGLILD HAQDEDDQDG HETDNCQRLL REACSQVLNI
760 770 780 790 800
PVERIAMSRA FAGHGGDSIT AMQVSSLIKR TQTLVVTVKD LLTCHSLAEA
810 820 830 840 850
ASSMREVVTS IQVPTAHPGK LYPLSPIQRL FMATAPTSVT WNHYNQSVLL
860 870 880 890 900
RIRERRSSDH VKESLGGVVR RHAMLRGRFQ RVSSSEWMQR ILPDDQGNLF
910 920 930 940 950
FEYFPDASDY KQREALMLKA RESLDIESGP LLRAQLFDGQ VEQGMLLFIV
960 970 980 990 1000
SHHLVVDLVS WRVILEELEV SLAQPYGNTT DANDISALLL PQESVPFPVW
1010 1020 1030 1040 1050
SELQHEAAKN MDPDRVIPQQ YAVPAPDFSY WGISSARNVY RDVIEKSISL
1060 1070 1080 1090 1100
GDMTTKNVLY ECHEALQTEP VDIFLSAILL SFKRAFPERP IPPIFNEGHG
1110 1120 1130 1140 1150
REPWTSDLDI SRTVGWFTTM FPIYVPNISA GDVVDTVRRV KDFRKGCAEN
1160 1170 1180 1190 1200
GFQYFSTKYL HEQGRKTFKD HIPAEIMFNY EGRYQSLEKE KSLLMAEAWE
1210 1220 1230 1240 1250
AGEALSDSAP ELQRFCLFEL SAAVLTDGEI HFTMAWNSRA RYQERISLWL
1260 1270 1280 1290 1300
TRLLPAVIDE IVTYLMLEKR QYTLSDLSQA RLSDYSDLET LMASVSTIPG
1310 1320 1330 1340 1350
IDSIEGVEEI YCGSPMQDSL ALSQSRISGG VYEIDLTWEV TDGRQGNYQV
1360 1370 1380 1390 1400
DVNRLVLAWN DVVARHAALR TVFLEAASSS NDVMLHQVVL RKYRPSTILM
1410 1420 1430 1440 1450
HTRDSSQALK QLSSCASYKK RGILIDKRPP HALAICSTDE GRTFVRFQVN
1460 1470 1480 1490 1500
HILFDGTSIA PLLRDLSRAY RNSHEVRREW TWNPFANFIR YIRDEKRRSD
1510 1520 1530 1540 1550
DLAYWKSYLA TARPCQFPTL KHEESIEAPG TEQQRGAVQV CMSDKPSSLR
1560 1570 1580 1590 1600
NFLADMGVTV PTLVQLVWAL VLRMYTSDSQ VAFGYLASGR DAPVVDIEQA
1610 1620 1630 1640 1650
VGPFISILVH FLDFDNEGQL PIADMLQRIQ DRSARSISHQ SRSLAEIQDA
1660 1670 1680 1690 1700
IGLTGSSLLF NTGISFMPKW TKDMQLRNGS GLIFDQIAAN DPTEFDISLI
1710 1720 1730 1740 1750
VETGDDGVDG MCIYVDYRTS TVGRMHAINI AASFDHILSQ IIQDPSVPLN
1760 1770 1780 1790 1800
DVSGISTRDF DQISNWNRLL SPPKDKCLHD LFIEKVIEDP TREAVFSWDG
1810 1820 1830 1840 1850
SMSYGELHDL SARLANYLVH LGVGPEQMIP ICFEKSVWTV VTILAVLKAG
1860 1870 1880 1890 1900
GCFVLLDPTH PASRLWNIVG EIEASILLCS PLTNRSKKLD ASPDMNARKA
1910 1920 1930 1940 1950
AIIEIHPSFV NNLKSVSRES QHTPLCPSLS PDNAAYVVFT SGSTGIPKGV
1960 1970 1980 1990 2000
VVTHRAVVTG LDELGRAAGM TAMGSGTRTL QFASYSFDAS IADIFCALQL
2010 2020 2030 2040 2050
GGCVCVMSDE GRSPADITDF IQRSRATYAG ITPSFASLLD PRLVPSLRVL
2060 2070 2080 2090 2100
CFSGEALPAS QIEAWSGYVK MVNMYGPTEA SIACIANSEV TRTTDASNIG
2110 2120 2130 2140 2150
RAFRGSTWIV DENDHNQLRA IGSSGELLIE GPILAREYLK RPEQTAQAFI
2160 2170 2180 2190 2200
SNPPWLQNIR PNSRLYKTGD MVRYNTNGTI SYIGRKDNQI KINGQRVEVS
2210 2220 2230 2240 2250
EIEETLRASI EPEAGLITVE LLDRKALGEA DVLTAFVYIA GHDPSSTRDD
2260 2270 2280 2290 2300
KADNKKPFTI PDNPLLLEYF RSMLPRLESS SSKMPRYMVP QAYIPIDSLP
2310 2320 2330 2340 2350
LTTSGKVDRR ALRHAAAQLN RNQLFSFASS LDMVHEPSVD VVKDDPVSEL
2360 2370 2380 2390 2400
AHLWESVLNV RVSGTQSNFF RLGGNSMAAM NLRSQARKAG FQLSVADILA
2410 2420 2430 2440 2450
NPTLSDMAKG MAPLSLTAPE STSSSSPQSF STSTSTTIIE NDPDTSPFSL
2460 2470 2480 2490 2500
LRTRGIALNE GLWQQMFDNA DILWSEVEDI FPCTPMQEGL MVLSAHREGH
2510 2520 2530 2540 2550
GAYALHAPYK LPSDLDLAKL QFAWEQTTMV HAILRSRIVT HSQGALIVLQ
2560 2570 2580 2590 2600
KSPVVVQQST CSTLDDHLEE QRRLIFGYGV PLFRMTMVFD QIAQCHYFVM
2610 2620 2630 2640 2650
SIHHALFDGW SFSRMWDTAL AIYQGRQLSR DIPSFQSFVQ HLGAAPLSAS
2660 2670 2680 2690 2700
KEYWKSHLVE QDRDGFQFPA VPSTHKPIAT ASASFEFAFQ STIAMSAGVT
2710 2720 2730 2740 2750
PSTMVHAAWA ILLSQYTASS TVNFGVTLSG RDFPMPGLDQ VVGATIVTLP
2760 2770 2780 2790 2800
RQLNINLNQN VIEFLEYVQQ EAANVIPHQY LGIHEIRALG LEAQQACNFS
2810 2820 2830 2840 2850
TLILVNHNTV DLDSPLSVFG ITQVPVDSVD FHPYPLAVEF TVQPESLVVN
2860 2870 2880 2890 2900
VCYDPVCIGG SMVESVMQQY DHVLQSLSEG LMCSSGLSGT NLASIMTGIA
2910 2920 2930 2940 2950
PAHLQKMLDW NKDGHRYGAS RQTHLVLDHI GLNTRNNPRA RAVVADDSTL
2960 2970 2980 2990 3000
SYAELNRLAR VVSHRITQLD ISGEFIAVCF DKSAAAIVSM LAVLQTGFAF
3010 3020 3030 3040 3050
MPISASQPPA RLENLLTAAN VQVVLTSPAH TDLLSGLSSH RRIVPVDLKD
3060 3070 3080 3090 3100
IDQHEQMQLN RSGSAVDKSR AAYLLYTSGT TGQPKGVVVQ HGAWSKAIAS
3110 3120 3130 3140 3150
QIDFFGFTRD TKMLQFSNYT FDASIFEIFI TLCSGGCLFV PSEHSRVNDL
3160 3170 3180 3190 3200
EGFIRTNELN TITLTPTVAR VIRPGQLPCV RQCLFGGESL TQSDIFAWAQ
3210 3220 3230 3240 3250
QGRRVTNCYG PTEACVFSCG RDIRLDATDT KVTNIGRPVG INAWIISSMS
3260 3270 3280 3290 3300
GSISPIGAPG ELCLEGQMLA RGYLNDPERT QLSFSNHLPN NIPGKKNSRT
3310 3320 3330 3340 3350
YRTGDMVCHE ADGTLNFLGR RDGQIKLRGH RIDVGEIEHH IQHAMADDST
3360 3370 3380 3390 3400
YHSSTVQVYW KDTRNKSDAE LAALLRMDIQ HKECVMGVPC SLLSMPGRAD
3410 3420 3430 3440 3450
ESPTASQLKF KLRRILPEHM TPNTFIAVQH FPTTASGKLD RSFAQRCVEY
3460 3470 3480 3490 3500
FVPYTQKEVN KNETWSSSEA IVREWWCSIL GVNTDLICRH DNFFGLGGNS
3510 3520 3530 3540 3550
IYAIRLVGLA RSNGHHLQYE DVFSSPVLAD MASRLSRPED SRVQSETRQP
3560 3570 3580 3590 3600
PEPFQLISES DLKSVMDDIL PLYNINKDEV EDIYPCTPLQ ATLMAETARH
3610 3620 3630 3640 3650
RGVYILAESI QVPSSQMTLF QDAWLLMFKS YEILRTRIVL SHDQSHGEWQ
3660 3670 3680 3690 3700
VVMKYQPLTW TEFPDAKSFI EFVYNTHDYG KPLVHLAILG GNGGRIKDTD
3710 3720 3730 3740 3750
HSVKVGLCVH HAAYDGWSLS NIWRTITKKL TSSSSYSVGP YTPFNTYIRH
3760 3770 3780 3790 3800
LTEQDPEKAK SYWKERFSGL SSASLIPRPQ DPGHQSSATD TIQRNLDLPT
3810 3820 3830 3840 3850
LSDHLLGKTA IVAQAAWAIT ISHYTANSDT LCGTILSGRE YAAASVPGVE
3860 3870 3880 3890 3900
TIVGPTIATV PSRTTINYDS CVLDLITAVQ KDNLNAVRFS HMGLEQISRL
3910 3920 3930 3940 3950
NLDCRQACKF DNLFWVQPDL DETPANSIIR DIINVRGFSS SPMVLEIQLP
3960 3970 3980 3990 4000
AEGQKVVVNM SFDRVAVSNQ QAELIVDTYI TIMDNLLHAP LDTRLRSIAA
4010 4020 4030 4040 4050
LSPAHISQIS RVSSSPVEAV QACVHDLVRK QVELSPSHTA IDAWDGSMAY
4060 4070 4080 4090 4100
AALDALSTSL AEKLSGLGIG PESPVCILFE KSKWAIVAML GVVKTGGCFV
4110 4120 4130 4140 4150
PLNPQSPIKR LQHLVESVDA SIILVSPQYE ELSISLSLHH VKILVISQDT
4160 4170 4180 4190 4200
IPSPISALKP SRAFPSSVGP QNAAYILFTS GSTGLPKGVV IEHQALCSSL
4210 4220 4230 4240 4250
TVLSSRVGLN SNSRVFQFNA YWFDVMLLDV FGTLISGGTI CAPSESDCMD
4260 4270 4280 4290 4300
DLAGSINKFN ANTIAALSTS VSRLIEPSSI PCLNTLGLGG EPVLSSDRDR
4310 4320 4330 4340 4350
WAPHVRLFSM YGPTETCIVS LMTDMTSTTP ASLLGHPVGC RVWIVNPLKN
4360 4370 4380 4390 4400
DELAPLGGIG ELFIEGPGLA RYYLVDEDKT AAAFLSNQSW TIQDPSFQGS
4410 4420 4430 4440 4450
RRFYKTGDLV RINTDGTVSW IGRKDHSQVK IRGQRVELAE IEETIRQHIP
4460 4470 4480 4490 4500
SALTVAVDIL IDGERRILAA VFGTNLMLPG LSDTEVEVYM EKLIKGLLPK
4510 4520 4530 4540 4550
LNGSLPKHMV PTAFIPLPFL PFLSTGKLDR KALHRLALPL AVELTKRTST
4560 4570 4580 4590 4600
NRQALKTPKE RLLSALWSEV LSTSKGEPAG PADNFFNAGG DSMMAMKLVA
4610 4620 4630 4640 4650
MARHRGLTLS VVDIFKNPIL SDMADLLGPL RHEEEPSKED STHMLPIDTS
4660 4670 4680 4690 4700
SKLKDSLYEV LTVPPDRIEQ IYPCTAYQEM FLSGTEVWPG AHVTQFIFSI
4710 4720 4730 4740 4750
DKGTDMHRLE KAMGRCTAEF PTLRTRIVRH GESGQLLQVV LHKGHEAPWS
4760 4770 4780 4790 4800
IHLTDDLDSA LDQEKKDHWM HSGLSEPLHR LSLVMNNSGC THLIWSLNHA
4810 4820 4830 4840 4850
AYDAWSFGMM LRSLGQDRAN STRHSRTCLP FNGLIRHISK LRDASSESRR
4860 4870 4880 4890 4900
FWRSYIADIG SQVLLFRYPS IADPRQDRLA VHQVSFPKHG GRSSTSLITA
4910 4920 4930 4940 4950
AWIMLLARLS HRKDITIAYL VTGRTLPLGG IDTCPGPLIS KLPLRIQLLD
4960 4970 4980 4990 5000
EPRGLVDVAD LVRIETVRVM PHEHTGLDAI KDLASQDDDD IHPHAASLLG
5010 5020 5030 5040 5050
RFPLDLAIHP AGHTDVDAAR SIGITHIGQK VVVPPPGTFS AECSIISEDN
5060 5070 5080
YIAVSLAVIW DNRAMDEDDV NRVVEIWKDI IVRG
Length:5,084
Mass (Da):562,186
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBCE0E79CE257757
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HF679023 Genomic DNA Translation: CCT63360.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CCT63360; CCT63360; FFUJ_00003

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF679023 Genomic DNA Translation: CCT63360.1

3D structure databases

SMRiS0DLP2
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiCCT63360; CCT63360; FFUJ_00003

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19327

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 3 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 4 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPF1_GIBF5
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S0DLP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: September 18, 2013
Last modified: May 8, 2019
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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