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UniProtKB - S0DLP2 (APF1_GIBF5)

Entry version 31 (11 Dec 2019)
Sequence version 1 (18 Sep 2013)
Previous versions | rss
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Protein

Apicidin F synthase

Gene

apf1

Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475). L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475). The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475). Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475). L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475). L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475). The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475). The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475). Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475). The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475). The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8). The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER-19327

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apicidin F synthaseCurated (EC:6.3.2.-1 Publication)
Alternative name(s):
Apicidin F synthesis protein 11 Publication
Non-ribosomal peptide synthetase apf11 Publication
Short name:
NRPS apf11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apf11 Publication
ORF Names:FFUJ_00003
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1279085 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Fusarium › Fusarium fujikuroi species complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000016800 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Apicidin F, like the other known apicidins, is a cyclic tetrapeptides with anti-malarial properties via histone deacetylase inhibitory activity (PubMed:24195442).1 Publication

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to the loss of apicidin F production (PubMed:25058475).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004371561 – 5084Apicidin F synthaseAdd BLAST5084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei768O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2376O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3500O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4592O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by the apicidin F cluster-specific transcription factor apf2 that binds to the eight-base-pair motif 5'-TGACGTGA-3' called the 'Api-box' that is found in all promoters of the apicidin F cluster except in the promoter region of apf2 itself (PubMed:25058475).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		S0DLP2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini731 – 808Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini2341 – 2415Carrier 2PROSITE-ProRule annotationAdd BLAST75
Domaini3463 – 3539Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4554 – 4631Carrier 4PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 606Adenylation 1Sequence analysisAdd BLAST398
Regioni822 – 1124Condensation 1Sequence analysisAdd BLAST303
Regioni1309 – 1609Condensation 2Sequence analysisAdd BLAST301
Regioni1788 – 2192Adenylation 2Sequence analysisAdd BLAST405
Regioni2478 – 2755Condensation 3Sequence analysisAdd BLAST278
Regioni2935 – 3328Adenylation 3Sequence analysisAdd BLAST394
Regioni3581 – 3866Condensation 4Sequence analysisAdd BLAST286
Regioni4029 – 4426Adenylation 4Sequence analysisAdd BLAST398
Regioni4669 – 4948Condensation 5Sequence analysisAdd BLAST280

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336 SSF47336, 4 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

S0DLP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIKMIDKQV LACNLDAFAG RVTNSTDINE QAIEWLSPTP SAVTLEAAWC 
        60         70         80         90        100
VTLRLYTGLD HLSFGSLTQD GIVATKLCNL GPHDTLEDVC SHVQLYDYSD 
       110        120        130        140        150
DTVCHYNTAV IFKLDENEGK KLSELIPRGI DVALMVTGSN LGVLARASFM 
       160        170        180        190        200
DADEARNLCQ NFRHVLNCFQ EPNQAVRGIT LSDNDVNQIL SWNKSQLTRT 
       210        220        230        240        250
ESLIHDQFAR ILQRQPDKSA IESWDGNMTY RELDAASSSL AESLSRANIG 
       260        270        280        290        300
PGSWVLFCFN KSRWAIVSML AILKAGGACV PLDPRHPKSR VVQILQATGA 
       310        320        330        340        350
QHILVGDADN DIKNRLCNEF PSVKVIGVPH HEVCESQDID TISLSFDSPA 
       360        370        380        390        400
IGLFTSGSTG TPKGIVATHA TICTGASSYA HHIGADDKTR VLQFASYTFD 
       410        420        430        440        450
VCMVDVFTAL LHGGTLCIPS EEERMTGLQE YISRTQPNWA ALTPTVARVL 
       460        470        480        490        500
DPALSSKSIR KILLVGEMVR ESDIAEWLDS GVQVYNVYGP AENNLITTAA 
       510        520        530        540        550
KAIRGRASNV GTGINTHTWV ADVENERLVP IGAVGELICS GPHLTPGYLN 
       560        570        580        590        600
DPERTASSFF EDLSWIPNMM DNKPFSRRFY RSGDLVRYCA DGSLQCVGRL 
       610        620        630        640        650
DSQVKLGGQR VELSEIESYI KSHNAAVLVP KAGSMKNKLI AVLEGAGSSG 
       660        670        680        690        700
QSLGISSCDP GVAQQVEQVL RKNLPSYMCP SIWISVPHLP LSSSGKLDRK 
       710        720        730        740        750
VLMNKLETLS HEEYLGLILD HAQDEDDQDG HETDNCQRLL REACSQVLNI 
       760        770        780        790        800
PVERIAMSRA FAGHGGDSIT AMQVSSLIKR TQTLVVTVKD LLTCHSLAEA 
       810        820        830        840        850
ASSMREVVTS IQVPTAHPGK LYPLSPIQRL FMATAPTSVT WNHYNQSVLL 
       860        870        880        890        900
RIRERRSSDH VKESLGGVVR RHAMLRGRFQ RVSSSEWMQR ILPDDQGNLF 
       910        920        930        940        950
FEYFPDASDY KQREALMLKA RESLDIESGP LLRAQLFDGQ VEQGMLLFIV 
       960        970        980        990       1000
SHHLVVDLVS WRVILEELEV SLAQPYGNTT DANDISALLL PQESVPFPVW 
      1010       1020       1030       1040       1050
SELQHEAAKN MDPDRVIPQQ YAVPAPDFSY WGISSARNVY RDVIEKSISL 
      1060       1070       1080       1090       1100
GDMTTKNVLY ECHEALQTEP VDIFLSAILL SFKRAFPERP IPPIFNEGHG 
      1110       1120       1130       1140       1150
REPWTSDLDI SRTVGWFTTM FPIYVPNISA GDVVDTVRRV KDFRKGCAEN 
      1160       1170       1180       1190       1200
GFQYFSTKYL HEQGRKTFKD HIPAEIMFNY EGRYQSLEKE KSLLMAEAWE 
      1210       1220       1230       1240       1250
AGEALSDSAP ELQRFCLFEL SAAVLTDGEI HFTMAWNSRA RYQERISLWL 
      1260       1270       1280       1290       1300
TRLLPAVIDE IVTYLMLEKR QYTLSDLSQA RLSDYSDLET LMASVSTIPG 
      1310       1320       1330       1340       1350
IDSIEGVEEI YCGSPMQDSL ALSQSRISGG VYEIDLTWEV TDGRQGNYQV 
      1360       1370       1380       1390       1400
DVNRLVLAWN DVVARHAALR TVFLEAASSS NDVMLHQVVL RKYRPSTILM 
      1410       1420       1430       1440       1450
HTRDSSQALK QLSSCASYKK RGILIDKRPP HALAICSTDE GRTFVRFQVN 
      1460       1470       1480       1490       1500
HILFDGTSIA PLLRDLSRAY RNSHEVRREW TWNPFANFIR YIRDEKRRSD 
      1510       1520       1530       1540       1550
DLAYWKSYLA TARPCQFPTL KHEESIEAPG TEQQRGAVQV CMSDKPSSLR 
      1560       1570       1580       1590       1600
NFLADMGVTV PTLVQLVWAL VLRMYTSDSQ VAFGYLASGR DAPVVDIEQA 
      1610       1620       1630       1640       1650
VGPFISILVH FLDFDNEGQL PIADMLQRIQ DRSARSISHQ SRSLAEIQDA 
      1660       1670       1680       1690       1700
IGLTGSSLLF NTGISFMPKW TKDMQLRNGS GLIFDQIAAN DPTEFDISLI 
      1710       1720       1730       1740       1750
VETGDDGVDG MCIYVDYRTS TVGRMHAINI AASFDHILSQ IIQDPSVPLN 
      1760       1770       1780       1790       1800
DVSGISTRDF DQISNWNRLL SPPKDKCLHD LFIEKVIEDP TREAVFSWDG 
      1810       1820       1830       1840       1850
SMSYGELHDL SARLANYLVH LGVGPEQMIP ICFEKSVWTV VTILAVLKAG 
      1860       1870       1880       1890       1900
GCFVLLDPTH PASRLWNIVG EIEASILLCS PLTNRSKKLD ASPDMNARKA 
      1910       1920       1930       1940       1950
AIIEIHPSFV NNLKSVSRES QHTPLCPSLS PDNAAYVVFT SGSTGIPKGV 
      1960       1970       1980       1990       2000
VVTHRAVVTG LDELGRAAGM TAMGSGTRTL QFASYSFDAS IADIFCALQL 
      2010       2020       2030       2040       2050
GGCVCVMSDE GRSPADITDF IQRSRATYAG ITPSFASLLD PRLVPSLRVL 
      2060       2070       2080       2090       2100
CFSGEALPAS QIEAWSGYVK MVNMYGPTEA SIACIANSEV TRTTDASNIG 
      2110       2120       2130       2140       2150
RAFRGSTWIV DENDHNQLRA IGSSGELLIE GPILAREYLK RPEQTAQAFI 
      2160       2170       2180       2190       2200
SNPPWLQNIR PNSRLYKTGD MVRYNTNGTI SYIGRKDNQI KINGQRVEVS 
      2210       2220       2230       2240       2250
EIEETLRASI EPEAGLITVE LLDRKALGEA DVLTAFVYIA GHDPSSTRDD 
      2260       2270       2280       2290       2300
KADNKKPFTI PDNPLLLEYF RSMLPRLESS SSKMPRYMVP QAYIPIDSLP 
      2310       2320       2330       2340       2350
LTTSGKVDRR ALRHAAAQLN RNQLFSFASS LDMVHEPSVD VVKDDPVSEL 
      2360       2370       2380       2390       2400
AHLWESVLNV RVSGTQSNFF RLGGNSMAAM NLRSQARKAG FQLSVADILA 
      2410       2420       2430       2440       2450
NPTLSDMAKG MAPLSLTAPE STSSSSPQSF STSTSTTIIE NDPDTSPFSL 
      2460       2470       2480       2490       2500
LRTRGIALNE GLWQQMFDNA DILWSEVEDI FPCTPMQEGL MVLSAHREGH 
      2510       2520       2530       2540       2550
GAYALHAPYK LPSDLDLAKL QFAWEQTTMV HAILRSRIVT HSQGALIVLQ 
      2560       2570       2580       2590       2600
KSPVVVQQST CSTLDDHLEE QRRLIFGYGV PLFRMTMVFD QIAQCHYFVM 
      2610       2620       2630       2640       2650
SIHHALFDGW SFSRMWDTAL AIYQGRQLSR DIPSFQSFVQ HLGAAPLSAS 
      2660       2670       2680       2690       2700
KEYWKSHLVE QDRDGFQFPA VPSTHKPIAT ASASFEFAFQ STIAMSAGVT 
      2710       2720       2730       2740       2750
PSTMVHAAWA ILLSQYTASS TVNFGVTLSG RDFPMPGLDQ VVGATIVTLP 
      2760       2770       2780       2790       2800
RQLNINLNQN VIEFLEYVQQ EAANVIPHQY LGIHEIRALG LEAQQACNFS 
      2810       2820       2830       2840       2850
TLILVNHNTV DLDSPLSVFG ITQVPVDSVD FHPYPLAVEF TVQPESLVVN 
      2860       2870       2880       2890       2900
VCYDPVCIGG SMVESVMQQY DHVLQSLSEG LMCSSGLSGT NLASIMTGIA 
      2910       2920       2930       2940       2950
PAHLQKMLDW NKDGHRYGAS RQTHLVLDHI GLNTRNNPRA RAVVADDSTL 
      2960       2970       2980       2990       3000
SYAELNRLAR VVSHRITQLD ISGEFIAVCF DKSAAAIVSM LAVLQTGFAF 
      3010       3020       3030       3040       3050
MPISASQPPA RLENLLTAAN VQVVLTSPAH TDLLSGLSSH RRIVPVDLKD 
      3060       3070       3080       3090       3100
IDQHEQMQLN RSGSAVDKSR AAYLLYTSGT TGQPKGVVVQ HGAWSKAIAS 
      3110       3120       3130       3140       3150
QIDFFGFTRD TKMLQFSNYT FDASIFEIFI TLCSGGCLFV PSEHSRVNDL 
      3160       3170       3180       3190       3200
EGFIRTNELN TITLTPTVAR VIRPGQLPCV RQCLFGGESL TQSDIFAWAQ 
      3210       3220       3230       3240       3250
QGRRVTNCYG PTEACVFSCG RDIRLDATDT KVTNIGRPVG INAWIISSMS 
      3260       3270       3280       3290       3300
GSISPIGAPG ELCLEGQMLA RGYLNDPERT QLSFSNHLPN NIPGKKNSRT 
      3310       3320       3330       3340       3350
YRTGDMVCHE ADGTLNFLGR RDGQIKLRGH RIDVGEIEHH IQHAMADDST 
      3360       3370       3380       3390       3400
YHSSTVQVYW KDTRNKSDAE LAALLRMDIQ HKECVMGVPC SLLSMPGRAD 
      3410       3420       3430       3440       3450
ESPTASQLKF KLRRILPEHM TPNTFIAVQH FPTTASGKLD RSFAQRCVEY 
      3460       3470       3480       3490       3500
FVPYTQKEVN KNETWSSSEA IVREWWCSIL GVNTDLICRH DNFFGLGGNS 
      3510       3520       3530       3540       3550
IYAIRLVGLA RSNGHHLQYE DVFSSPVLAD MASRLSRPED SRVQSETRQP 
      3560       3570       3580       3590       3600
PEPFQLISES DLKSVMDDIL PLYNINKDEV EDIYPCTPLQ ATLMAETARH 
      3610       3620       3630       3640       3650
RGVYILAESI QVPSSQMTLF QDAWLLMFKS YEILRTRIVL SHDQSHGEWQ 
      3660       3670       3680       3690       3700
VVMKYQPLTW TEFPDAKSFI EFVYNTHDYG KPLVHLAILG GNGGRIKDTD 
      3710       3720       3730       3740       3750
HSVKVGLCVH HAAYDGWSLS NIWRTITKKL TSSSSYSVGP YTPFNTYIRH 
      3760       3770       3780       3790       3800
LTEQDPEKAK SYWKERFSGL SSASLIPRPQ DPGHQSSATD TIQRNLDLPT 
      3810       3820       3830       3840       3850
LSDHLLGKTA IVAQAAWAIT ISHYTANSDT LCGTILSGRE YAAASVPGVE 
      3860       3870       3880       3890       3900
TIVGPTIATV PSRTTINYDS CVLDLITAVQ KDNLNAVRFS HMGLEQISRL 
      3910       3920       3930       3940       3950
NLDCRQACKF DNLFWVQPDL DETPANSIIR DIINVRGFSS SPMVLEIQLP 
      3960       3970       3980       3990       4000
AEGQKVVVNM SFDRVAVSNQ QAELIVDTYI TIMDNLLHAP LDTRLRSIAA 
      4010       4020       4030       4040       4050
LSPAHISQIS RVSSSPVEAV QACVHDLVRK QVELSPSHTA IDAWDGSMAY 
      4060       4070       4080       4090       4100
AALDALSTSL AEKLSGLGIG PESPVCILFE KSKWAIVAML GVVKTGGCFV 
      4110       4120       4130       4140       4150
PLNPQSPIKR LQHLVESVDA SIILVSPQYE ELSISLSLHH VKILVISQDT 
      4160       4170       4180       4190       4200
IPSPISALKP SRAFPSSVGP QNAAYILFTS GSTGLPKGVV IEHQALCSSL 
      4210       4220       4230       4240       4250
TVLSSRVGLN SNSRVFQFNA YWFDVMLLDV FGTLISGGTI CAPSESDCMD 
      4260       4270       4280       4290       4300
DLAGSINKFN ANTIAALSTS VSRLIEPSSI PCLNTLGLGG EPVLSSDRDR 
      4310       4320       4330       4340       4350
WAPHVRLFSM YGPTETCIVS LMTDMTSTTP ASLLGHPVGC RVWIVNPLKN 
      4360       4370       4380       4390       4400
DELAPLGGIG ELFIEGPGLA RYYLVDEDKT AAAFLSNQSW TIQDPSFQGS 
      4410       4420       4430       4440       4450
RRFYKTGDLV RINTDGTVSW IGRKDHSQVK IRGQRVELAE IEETIRQHIP 
      4460       4470       4480       4490       4500
SALTVAVDIL IDGERRILAA VFGTNLMLPG LSDTEVEVYM EKLIKGLLPK 
      4510       4520       4530       4540       4550
LNGSLPKHMV PTAFIPLPFL PFLSTGKLDR KALHRLALPL AVELTKRTST 
      4560       4570       4580       4590       4600
NRQALKTPKE RLLSALWSEV LSTSKGEPAG PADNFFNAGG DSMMAMKLVA 
      4610       4620       4630       4640       4650
MARHRGLTLS VVDIFKNPIL SDMADLLGPL RHEEEPSKED STHMLPIDTS 
      4660       4670       4680       4690       4700
SKLKDSLYEV LTVPPDRIEQ IYPCTAYQEM FLSGTEVWPG AHVTQFIFSI 
      4710       4720       4730       4740       4750
DKGTDMHRLE KAMGRCTAEF PTLRTRIVRH GESGQLLQVV LHKGHEAPWS 
      4760       4770       4780       4790       4800
IHLTDDLDSA LDQEKKDHWM HSGLSEPLHR LSLVMNNSGC THLIWSLNHA 
      4810       4820       4830       4840       4850
AYDAWSFGMM LRSLGQDRAN STRHSRTCLP FNGLIRHISK LRDASSESRR 
      4860       4870       4880       4890       4900
FWRSYIADIG SQVLLFRYPS IADPRQDRLA VHQVSFPKHG GRSSTSLITA 
      4910       4920       4930       4940       4950
AWIMLLARLS HRKDITIAYL VTGRTLPLGG IDTCPGPLIS KLPLRIQLLD 
      4960       4970       4980       4990       5000
EPRGLVDVAD LVRIETVRVM PHEHTGLDAI KDLASQDDDD IHPHAASLLG 
      5010       5020       5030       5040       5050
RFPLDLAIHP AGHTDVDAAR SIGITHIGQK VVVPPPGTFS AECSIISEDN 
      5060       5070       5080 
YIAVSLAVIW DNRAMDEDDV NRVVEIWKDI IVRG
Length:5,084
Mass (Da):562,186
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBCE0E79CE257757
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
HF679023 Genomic DNA Translation: CCT63360.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		CCT63360; CCT63360; FFUJ_00003

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF679023 Genomic DNA Translation: CCT63360.1

3D structure databases

SMRiS0DLP2
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiCCT63360; CCT63360; FFUJ_00003

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19327

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 3 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 4 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPF1_GIBF5
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: S0DLP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: September 18, 2013
Last modified: December 11, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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