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Entry version 31 (02 Jun 2021)
Sequence version 1 (18 Sep 2013)
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Protein
Submitted name:

Ryanodine receptor

Gene
N/A
Organism
Pieris rapae (Small white butterfly) (Artogeia rapae)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorImported
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.1.4, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPieris rapae (Small white butterfly) (Artogeia rapae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri64459 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPieridaePierinaePieris

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4454 – 4474HelicalSequence analysisAdd BLAST21
Transmembranei4639 – 4660HelicalSequence analysisAdd BLAST22
Transmembranei4720 – 4739HelicalSequence analysisAdd BLAST20
Transmembranei4907 – 4929HelicalSequence analysisAdd BLAST23
Transmembranei4983 – 5006HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 149MIRInterPro annotationAdd BLAST55
Domaini156 – 201MIRInterPro annotationAdd BLAST46
Domaini211 – 265MIRInterPro annotationAdd BLAST55
Domaini271 – 329MIRInterPro annotationAdd BLAST59
Domaini337 – 395MIRInterPro annotationAdd BLAST59
Domaini578 – 804B30.2/SPRYInterPro annotationAdd BLAST227
Domaini1036 – 1219B30.2/SPRYInterPro annotationAdd BLAST184
Domaini1475 – 1690B30.2/SPRYInterPro annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1365 – 1477DisorderedSequence analysisAdd BLAST113
Regioni2288 – 2308DisorderedSequence analysisAdd BLAST21
Regioni2821 – 2842DisorderedSequence analysisAdd BLAST22
Regioni2930 – 2952DisorderedSequence analysisAdd BLAST23
Regioni3588 – 3611DisorderedSequence analysisAdd BLAST24
Regioni3856 – 3888DisorderedSequence analysisAdd BLAST33
Regioni4483 – 4574DisorderedSequence analysisAdd BLAST92
Regioni4673 – 4699DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 481Sequence analysisAdd BLAST21
Coiled coili2134 – 2161Sequence analysisAdd BLAST28
Coiled coili3793 – 3813Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1380 – 1413Polar residuesSequence analysisAdd BLAST34
Compositional biasi1420 – 1471Basic and acidic residuesSequence analysisAdd BLAST52
Compositional biasi2825 – 2842Polar residuesSequence analysisAdd BLAST18
Compositional biasi3859 – 3874Acidic residuesSequence analysisAdd BLAST16
Compositional biasi4489 – 4503Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi4537 – 4554Polar residuesSequence analysisAdd BLAST18
Compositional biasi4678 – 4692Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 1 hit
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

R9R5D5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN
60 70 80 90 100
IADKNIPPDL SQCVFVIEQA LSVRALQELV TAAGSETGKG TGSGHRTLLY
110 120 130 140 150
GNAILLRHLN SDMYLACLST SSSQDKLASD VGLQEHSQGE ACWWTLHPAS
160 170 180 190 200
KQRSEGEKVR VGDDLILVSV ATERYLHTTK ENEVSIVNAS FHVTHWSVQP
210 220 230 240 250
YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSTWNKDG GLNIVVYEGG
260 270 280 290 300
SVMSQARSLW RLELARTKWA GGFINWYHPM RIRHITTGRY LGVNDQNELY
310 320 330 340 350
LVSREEATTA SCAFCLRQEK NDQKVVLEDK DLEVIGAPII RYGDSTVIVQ
360 370 380 390 400
HSETGLWLSY KSYETKKKGL GKVEEKQAIL HEEGKMDDGL DFSRSQEEES
410 420 430 440 450
RTARVIRKCS SLFTKFINGL ETLQENRRHS MFFASVNLGE MVMCLEDLIN
460 470 480 490 500
YFAQPEEDME HEEKQNRFRA LRNRQDLFQE EGILNLILEA IDKINVITSQ
510 520 530 540 550
GFLAGFLAGY ESGQSWDMIS VYLYQLLAAI IKGNHTNCAQ FANSNRLNWL
560 570 580 590 600
FSRLGSQASG EGTGMLDVLH CVLIDSPEAL NMMRDEHIKV IISLLEKHGR
610 620 630 640 650
DPKVLDVLCS LCVGNGVAVR SSQNNICDYL LPGKNLLLQT ALVDHVSSVR
660 670 680 690 700
PNIFVGRVEG SAVYQKWYFE ATMDHIEKTT HMMPHLRIGW ANTSGYVPYP
710 720 730 740 750
GGGEKWGGNG VGDDLYSFGF DGAYLWSGGR KIQVNKTHAE EPFIRKGDVI
760 770 780 790 800
GCALNLTVPI INFMFNGVKV TGSFPNFNLE RNVLPCHELS SKLKLPFSHG
810 820 830 840 850
KRTTGRAKDT PGLPEGYSPL VESLLPQQIL NLEPCFYFGN LSKRALAGPP
860 870 880 890 900
LVQDDTAFVP TPVDTASITL SSYIEQIRDK LAENIHEMWA MNKIEAGWMY
910 920 930 940 950
GDQRDDLHKV HPCLVPFERL PAAEKRYDIQ LAVQTLKTIL ALGYYISLDK
960 970 980 990 1000
PPARIRNVRL PNEPFMQSNG YKPAPLDLSA VTLTPKMDEL VDQLAENTHN
1010 1020 1030 1040 1050
LWARERIQQG WTYGLNEDPD MNRSPHLVPY PKVDDAIKKA NRDTASETVR
1060 1070 1080 1090 1100
TLLVYGYNLD PPTGEQHEAL LAEASRQKQA EFRTYRAEKN YAVSSGKWYF
1110 1120 1130 1140 1150
EFEILTAGPM RVGWAHADMP PGMMLGQDEN SWAFDGYNEE KVYSGSLESF
1160 1170 1180 1190 1200
GKQWAVGDVV GVFLDLIDKT ISFSLNGELL MDALGGETTF ADVQGDNFVP
1210 1220 1230 1240 1250
ACTLGVGQKA RLSYGQDVNS LKYFTTCGLQ EGYEPFCVNM NRDVTHWYTK
1260 1270 1280 1290 1300
DQPMFENTDE MIDTRIDVTR IPAGSDTPPC LKISHNTFET MEKANWEFLR
1310 1320 1330 1340 1350
LSLPVICHAE FIDESEKARR WVEIKDRQQI LMKEAVEAQM PAHIDQIMRS
1360 1370 1380 1390 1400
GFTMNDIKGL HYDENQEDVK IKRQPSRPPR KGSITRNVTI QNYNSQSGQN
1410 1420 1430 1440 1450
GMNRSTSEAE MSKYELGVQN LPEDTKKDKR GRSPFKFFRS KRGESGDRGK
1460 1470 1480 1490 1500
SRKSKTPDPY TDTEVSPDRA RRPNPQIRIS QANQRYNMQN RNDGANIYDS
1510 1520 1530 1540 1550
QGALSTNLTV PTPTQDRKQM TTATLDKSAT ETIGNEIFDA DCLKLINGYF
1560 1570 1580 1590 1600
YGVRIFPGQD PTHVYIGWVT TQYHLHSKDF NQNKVTKSSV IITDDYDRVI
1610 1620 1630 1640 1650
ESVNRQSCYM VRADELYNEV MAEATAKGAS QGMFIGCSVD TSTGTVSFTC
1660 1670 1680 1690 1700
EGKDTSIKFK MEPETKLFPA IFVEATSKEI LQIELGRSST SLPLSAAVLP
1710 1720 1730 1740 1750
TSDKHVNPQF PPRLKVQCLK PHQWARVPNQ FLQVHALKLS DIRGWSMLCE
1760 1770 1780 1790 1800
DAVSMLALHI PEEDRCIDIL ELIEMDKLLS FHAHTLTLYA ALCYQSNYRA
1810 1820 1830 1840 1850
AHALCQHVDQ KQLLYAIRSQ YMSGPLRQGF YDLLIALHLE SHATTMEACK
1860 1870 1880 1890 1900
NEFVIPLGPE LKALYEDREM CHSLRSLQTE SVRPQMNMTN IAENISDISN
1910 1920 1930 1940 1950
LYFPYFPLEV VREFVMQALA EAVETNQVHS RDPTGGSNEN LFLPLIKLVD
1960 1970 1980 1990 2000
RLLLVGMMRD EDVEKLLIMI NPETWDPTFD KEGKDEHRKG LLHMKMAEGA
2010 2020 2030 2040 2050
KLQMCYLLQH LNDIQLRHRV ESIIAFAHDF VGELQTDQLR RYTEIKQSDL
2060 2070 2080 2090 2100
PSAVAAKKTR EFRCPPREQM NAILSFKHLE DEDPENCPCG EELIARMNDF
2110 2120 2130 2140 2150
HDALMSHVSL SALQEPDGDQ SNEPEVKPGA FGKLYNIINT VKELEDDAKA
2160 2170 2180 2190 2200
LEEEKKKTPE EKFRKVLIQT IVNWAEESRI ETPKLVREMF SLLVRQYDAV
2210 2220 2230 2240 2250
GELIRALEKT YVINAKTKLD VAEMWVGLSQ IRALLPVQMS QEEEELMRKR
2260 2270 2280 2290 2300
LWKLVNNHTF FQHPDLIRVL RVHENVMAVM MNTLGRRAQA QSDAPATSPP
2310 2320 2330 2340 2350
TPEDKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD FLLENSNILL
2360 2370 2380 2390 2400
ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE
2410 2420 2430 2440 2450
LIEKGYPDLG WDPVEGERYL DFLRFCVWVN DESVEENANL VIRLLIRRPE
2460 2470 2480 2490 2500
CLGPALRGEG EGLLKAIVDA NKMSERIADR RKLRDLEQEG DISFSHPLPE
2510 2520 2530 2540 2550
SEDDEDYIDT GAAILNFYCT LVDLLGRCAP DAGVIALGKN ESLRARAILR
2560 2570 2580 2590 2600
SLVPLEDLQG VLSLRFTLNN PAAGEERPKS DMPSGLIPGH KQSVGLFLER
2610 2620 2630 2640 2650
VYGIETQELF YRLLEEAFLP DLRAATMLDR NDGCESDMAL SMNRYIGNSI
2660 2670 2680 2690 2700
LPLLIKHANF YNEAENYASL LDATLHTVYR LSKNRMLTKG QREAVSDFLV
2710 2720 2730 2740 2750
ALTSAMQPSM LLKLLRKLKL TVDVSRLSEY TTVALRLLTL HYERCAKYYG
2760 2770 2780 2790 2800
STGGQGSYGS SSDEEKRLTM MLFSNIFDSL SKMDYEPELF GKALPCLIAI
2810 2820 2830 2840 2850
GCALPPDYSL SKNYDDEFYG KDSQASGADN PQYDPQPINT SSVALNNDLN
2860 2870 2880 2890 2900
TIVQKFSEHY HDAWASRKIE NGWVYGENWS DSQKTHPRLK PYNMLNDYEK
2910 2920 2930 2940 2950
ERYKEPVRES LKALLAIGWS VEHSEVDIPS NNRSSMRRQS KSGIDSATPF
2960 2970 2980 2990 3000
NYNPHPVDMT NLTLSREMQN MAERLADNAH DIWAKKKKEE LVTSGGGIHP
3010 3020 3030 3040 3050
QLVPYDLLTD KEKKKDRERS QELLKYLQYQ GYKLHRPSKA SQIDTEQTTT
3060 3070 3080 3090 3100
GVAIELRFAY SLLEKLIQYI DRATINMKLL KPSTTFSRRS SFKTSTRDIK
3110 3120 3130 3140 3150
FFSKVVLPLM EKYFSTHRNY FIAVATATNN VGAASLKEKE MVAALFCKLA
3160 3170 3180 3190 3200
SLLRSRLAAF GPDVRITVRC LQVLVKGIDA KPLVKNCPEF IRTSMLTFFN
3210 3220 3230 3240 3250
NLADDLGHTI FNLQEGKYAH LRGTHLKTST SLGYINGVML PILTAMFDHL
3260 3270 3280 3290 3300
ANCEYGADLL LDEIQVASYK MLGSSYTLGT DVTLTHDRKY LKTEIERHKP
3310 3320 3330 3340 3350
ALGSCLGAFS STFPVAFLEP HLNKHNQFSL LNRIADHSLE AQDIMAKMEQ
3360 3370 3380 3390 3400
SMPTLETILN EVDHFVESDK TYSEAPHIID VVLPLLCSYL PFWWAQGPDN
3410 3420 3430 3440 3450
VTPTGGNHVA MVTADHMNQL LKNVLKLIKK NIGNENAPWM TRIATYTQQI
3460 3470 3480 3490 3500
IINSSEELLR ESFLPLAERV RKRTDNMFHK EESLRGFIKS STDDTSQVES
3510 3520 3530 3540 3550
QIQEDWQLLV RDIYSFYPLL IKYVDLQRNH WLRNNVPEAE ELYNHVAEVF
3560 3570 3580 3590 3600
NIWSKSQYFL KEEQNFISAN EIDNMVLIMP TATRRVTTVV DGTQQGGGKK
3610 3620 3630 3640 3650
KKKHRDKKRD KDKEVQASLM VACLKRLLPV GLNLFAGREQ ELVQHCKDRF
3660 3670 3680 3690 3700
LKKMSEQDVA EFAKTQLTLP DKIDPADEMS WQHYLYSKLG SKSKTAITVE
3710 3720 3730 3740 3750
TSENKVKIID DTVERIVAMS KVLFGLHMID HPQQMSKNVY RSVVSIQRKR
3760 3770 3780 3790 3800
AVIACFRQTS LHSLPRHRAC NIFARTYYEL WVEEENIGQE VMIEDLTQTF
3810 3820 3830 3840 3850
EDAELKKSDI VEEEGKPDPL TQLVTTFCRG AMTERSGALQ EDPLYMSYAH
3860 3870 3880 3890 3900
IIAKSCGEEE EEGGEEEEGG GEPEGEDEGK SSIHEQEMEK QKLLFHQARL
3910 3920 3930 3940 3950
ANRGVAEMVL LHISASKGVP SDMVMKTLQL GISILRGGNI DIQMGMLNHL
3960 3970 3980 3990 4000
KDKKDVGFFT SIAGLMNSCS VLDLDAFERN TKAEGLGVGL EGAAGEKNMH
4010 4020 4030 4040 4050
DAEFTCALFR FIQLTCEGHN LEWQNYLRTQ AGNTTTVNVV ICTVDYLLRL
4060 4070 4080 4090 4100
QESIMDFYWH YSSKELIDPA GKANFFKAIG VASQVFNTLT EVIQGPCTQN
4110 4120 4130 4140 4150
QQALAHSRLW DAVGGFLFLF SHMQDKLSKH SSQVDLLKEL LNLQKDMITM
4160 4170 4180 4190 4200
MLSMLEGNVV NGTIGKQMVD TLVESASNVE LILKYFDMFL KLKDLTSSAS
4210 4220 4230 4240 4250
FKEIDANNDG WVLPKDFKEK MEQQKSYSPE EIEFLLACCE TNHDGKLDYI
4260 4270 4280 4290 4300
GFCDRFHEPA KEIGFNLAVL LTNLSEHMPN EPRLARFLET AGSVLNXFEP
4310 4320 4330 4340 4350
FLGRIEIMGG SKRIERVYFE IKESNIEQWE KPQIKESKRA FFYSIVTEGG
4360 4370 4380 4390 4400
DKEKLEAFVN FCEDAIFEMT HASGLMAASE ESASGPKNRE AAYTYLGDDD
4410 4420 4430 4440 4450
DERAGKDPFR RGYQSVKDAI AATFSFLSPS NIKAKIADMQ QMPPAELLVG
4460 4470 4480 4490 4500
FLKLFFYLFY YIGYGFVVVI RYIFGVLLGL MRGPHVEEPP PQEPTEEEKI
4510 4520 4530 4540 4550
GPSRHLPALP ATDDTGQMQV SAFGLDITKE DNGQLQVKPH ESPTTSTPSS
4560 4570 4580 4590 4600
GEEAEVSPDE SIEHTEEQQP PSLIDLLGGE QAKKQAQERV EAQAAQQAAM
4610 4620 4630 4640 4650
SAIEAESKKA VQVPAPSALS QVDLSQYTKR AVSFLARNFY NLKYVALVLA
4660 4670 4680 4690 4700
FCINFVLLFY KVSIPDSDKE GSGIGDIISG SGSGQGSGSG EGSGESEDDD
4710 4720 4730 4740 4750
SLEVVRIDED FFYMEHVIKM AAALHSIVSL AILIGYYHLK VPLAIFKRGK
4760 4770 4780 4790 4800
DIARRLEFDG LYIAEQPEDD DLKSHWDKLV ISAKSFPVNY WDKFIKKKVR
4810 4820 4830 4840 4850
AKYSETYDFD SISNMLGMEK TSFSAQEDEG NKGLWNYIVN IDWRYQVWKA
4860 4870 4880 4890 4900
GVTITDNSFL YSLWYFSFSV MGNFNNFFFA AHLLDVAVGF KTLRTILQSV
4910 4920 4930 4940 4950
THNGKQLVLT VMLLTIIVYI YTVIAFNFFR KFYVQEEDDE INRNCHDMLS
4960 4970 4980 4990 5000
CFVFNLYKGV RAGGGIGDEL EPPDGDDSEV YRIIFDISFF FFVIIILLAI
5010 5020 5030 5040 5050
LQGLIIDAFG ELRDQLESVK EDMESNCFIC GINKDYFDKV PHGFDTHVQR
5060 5070 5080 5090 5100
EHNLANYMFF LMHLINKPDT EYTGQETFVW NMYTQRCWDF FPVGDCFRKQ

YEDVMGE
Length:5,107
Mass (Da):578,230
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B2F88439E6D9697
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JX481776 mRNA Translation: AGI62938.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX481776 mRNA Translation: AGI62938.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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Protein family/group databases

TCDBi1.A.3.1.4, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 2 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 1 hit
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR9R5D5_PIERA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R9R5D5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: June 2, 2021
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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