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Entry version 47 (10 Feb 2021)
Sequence version 1 (18 Sep 2013)
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Protein

3C-like proteinase

Gene
N/A
Organism
Bat coronavirus Cp/Yunnan2011
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-bindingARBA annotation, Thiol proteaseARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation)
Alternative name(s):
Growth factor-like peptideARBA annotation
Leader proteinARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
Papain-like proteinaseARBA annotation
p65 homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBat coronavirus Cp/Yunnan2011Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1283333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusSarbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000127630 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2204 – 2232HelicalSequence analysisAdd BLAST29
Transmembranei2315 – 2337HelicalSequence analysisAdd BLAST23
Transmembranei2343 – 2371HelicalSequence analysisAdd BLAST29
Transmembranei2750 – 2769HelicalSequence analysisAdd BLAST20
Transmembranei3021 – 3043HelicalSequence analysisAdd BLAST23
Transmembranei3055 – 3079HelicalSequence analysisAdd BLAST25
Transmembranei3116 – 3135HelicalSequence analysisAdd BLAST20
Transmembranei3560 – 3583HelicalSequence analysisAdd BLAST24
Transmembranei3589 – 3607HelicalSequence analysisAdd BLAST19
Transmembranei3614 – 3635HelicalSequence analysisAdd BLAST22
Transmembranei3661 – 3679HelicalSequence analysisAdd BLAST19
Transmembranei3686 – 3702HelicalSequence analysisAdd BLAST17
Transmembranei3722 – 3744HelicalSequence analysisAdd BLAST23
Transmembranei3756 – 3775HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1004 – 1170MacroInterPro annotationAdd BLAST167
Domaini1612 – 1876Peptidase C16InterPro annotationAdd BLAST265
Domaini3242 – 3547Peptidase C30InterPro annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni973 – 1003DisorderedSequence analysisAdd BLAST31
Regioni1177 – 1196DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi973 – 998AcidicSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

R9QTH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLVLGINE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKSGT
60 70 80 90 100
CGIVELEKGV LPQLEQPYVF IKRSDAQGTG HGHKVCELVA ELDGVQFGRS
110 120 130 140 150
GITLGVLVPY VGETPIAYRT VLLRKNGNKG AGGHSFGIDL KSYDLGDELG
160 170 180 190 200
TDPIEDYEQN WNTKHGSGAL RELTRELNGG VVTRYVDNNF CGPDGYPLEC
210 220 230 240 250
IKDLLARAGK SMCTLSEQLD FIESKRGVYC CREHEHEIAW FTERSEKSYE
260 270 280 290 300
HQTPFEIKSA KKFDTFKGEC PKFVFPLNSR VKVIQPRVEK KKTEGFMGRI
310 320 330 340 350
RSVYPVASPG DCNDMHLSTL MKCNHCDEVS WQTCDFLKAT CEQCGTENSV
360 370 380 390 400
REGPTTCGYL PTNAVLKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG
410 420 430 440 450
GRIKCFGGCV FAYVGCYNKR AYWVPRASAD IGANHTGITG DNVETLNEDL
460 470 480 490 500
LEILRRERVN INIVGDFQLN EEVAIILASF SASTSAFIDT VKGLDYKTFK
510 520 530 540 550
AIVESCGNYK VTKGKPVQGA WNIGQQKSIL TPLCGFPSRA ASVIRSIFSR
560 570 580 590 600
TLDAANHSIP DLQKAAVTIL DGISEHSLRL VDAMTYTSDL FTNSVIIMAY
610 620 630 640 650
VTGGLVQQVS QWLSNLVGSA AEKLRPVFAW VESRLSDGIE FLKDAWEILK
660 670 680 690 700
FLIRGVFDIV KGQIQVTSDN IKECVKSFID VINKALEMCI DYVTVAGTKL
710 720 730 740 750
RSLNLGEIFI AQSKGLYRQC IRGKEQLQLL MPLKAPKDVT FFEGDVHDTV
760 770 780 790 800
LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCINGLML LELKDKEQYC
810 820 830 840 850
ALSPGLLATN NVFRLKGGAP TKGVTFGEDT VVEVQGYKNV KITFELDERV
860 870 880 890 900
DKVLNEKCSV YTVESGTEVS EFACVVAEAV VKTLQPVSDL LTNMGIDLDE
910 920 930 940 950
WSVATFYLFD DSGEENLSSR MYCSFYPPDE EEEGDAECEE EEIADETCEH
960 970 980 990 1000
EYGTEDDYQG LPMEFGASTE TVQVEEEEEE DWLDDTTEQS EIEPEPEPTS
1010 1020 1030 1040 1050
EEPVNQFTGY LKLTDNVAIK CVDIVKEAQN ANPTVIVNAA NVHLKHGGGV
1060 1070 1080 1090 1100
AGALNKATNG AMQKESDDYI KLNGPLTVGG SCLLSGHNLA KKCLHVVGPN
1110 1120 1130 1140 1150
LNVGEDIQLL KAAYENFNSQ DTLLAPLLSA GIFGAKPLQS LQVCVQTVRT
1160 1170 1180 1190 1200
QVYIAVNDKA LYEQVVMDYL DSLKPRVEAP KQEEPPKTED PKIEEKSVVQ
1210 1220 1230 1240 1250
KPVDVKPKIK ACIDEVTTTL EETKFLTNKL LLFADINGKL YHDSQNMLRG
1260 1270 1280 1290 1300
EDISFLEKDA PYMVGDVITS GDITCVIIPS KKAGGTTEML SRALKKVPVD
1310 1320 1330 1340 1350
EYITTYPGQG CAGYTLEEAK TALKKCKSAF YVLPSESPNA KEEILGTVSW
1360 1370 1380 1390 1400
NLREMLAHAE ETRKLMPICM DVRAIMATIQ RKYKGIKIQE GIVDYGVRFF
1410 1420 1430 1440 1450
FYTSKEPVAS IITKLNSLNE PLVTMPIGYV THGFNLEEAA RCMRSLKAPA
1460 1470 1480 1490 1500
VVSVSSPDAV TTYNGYLTSS SKTSEEHFVE TVSLAGSYRD WSYSGQRTEL
1510 1520 1530 1540 1550
GVEFLKRGDK IVYHTLESPV EFHLDGEVLP LDKLKSLLSL REVKTIKVFT
1560 1570 1580 1590 1600
TVDNTNLHTQ LVDMSMTYGQ QFGPTYLDGA DVTKIKPHVN HEGKTFFVLP
1610 1620 1630 1640 1650
SDDTLRSEAF EYYHTLDESF LGRYMSALNH TKKWKFPQVG GLTSIKWADN
1660 1670 1680 1690 1700
NCYLSSVLLA LQQIEVKFNA PALQEAYYRA RAGDAANFCA LILAYSNKTV
1710 1720 1730 1740 1750
GELGDVRETM AHLLQHANLE SAKRVLNVVC KHCGQKTTTL TGVEAVMYMG
1760 1770 1780 1790 1800
TLSYDNLKTG VSVPCVCGRD ATQYLVQQES SFVMMSAPPA EYKLQQGTFL
1810 1820 1830 1840 1850
CANEYTGNYQ CGHYTHITAK ETLYRIDGAH LTKMSEYKGP VTDVFYKETS
1860 1870 1880 1890 1900
YTTTIKPVSY KLDGVTYTEI EPKLDGYYKK DNAYYTEQPI DLVPTQPLPN
1910 1920 1930 1940 1950
ASFDNFKLTC SNIKFADDLN QMTGFTKPAS RELSVTFFPD LNGDVVAIDY
1960 1970 1980 1990 2000
RHYSASFKKG AKLLHKPIVW HINQATTKTT FKPNTWCLRC LWSTKPVDTS
2010 2020 2030 2040 2050
NSFEVLAVED TQGMDNLACE SQQPTSEEVV ENPTIQKEVI ECDVKTTEVV
2060 2070 2080 2090 2100
GNVILKPSDE GVKVTQELGH EDLMAAYVEN TSITIKKPNE LSLALGLKTI
2110 2120 2130 2140 2150
ATHGIAAINS VPWSKILAYV GPFLGRTAIT TSNCAKRLVQ RVFNNYMPYV
2160 2170 2180 2190 2200
LTLLFQLCTF TKSTNSRIRA SLPTTIAKNS VKGVAKLCLD AGINYVKSPK
2210 2220 2230 2240 2250
FSKLFIIAMW LLLLSICLGS LIYVTAALGV LLSNFGAPSY CSGVRESYLN
2260 2270 2280 2290 2300
SSNVTTMDFC EGSFPCSVCL SGLDSLDSYP ALETIQVTIS SYKLDLTILG
2310 2320 2330 2340 2350
LVAEWFLAYM LFTKFFYLLG LSAIMQVFFG YFASHFISNS WLMWFIISIV
2360 2370 2380 2390 2400
QMAPVSAMVR MYIFFASFYY IWKSYVHIMD GCTSSTCMMC YKRNRATRVE
2410 2420 2430 2440 2450
CTTIVNGMKR SFYVYANGGR GFCKTHNWNC LNCDTFCTGS TFISDEVARD
2460 2470 2480 2490 2500
LSLQFKRPIN PTDQSLYIVD SVAVKNGALH LYFDKAGQKT YERHPLSHFV
2510 2520 2530 2540 2550
NLDNLRANNT KGSLPINVIV FDGKSKCDES AARSASVYYS QLMCQPILLL
2560 2570 2580 2590 2600
DQALVSDVGD STEVSVKMFD AYVDTFSATF SVPMEKLKAL VATAHSELAK
2610 2620 2630 2640 2650
GVALDGVLST FVSAARQGVV DTDVDTKDVI ECLKISHHSD LEVTGDSCNN
2660 2670 2680 2690 2700
FMLTYNKVEN MTPRDLGACI DCNARHINAQ VAKSHNVSLI WNVKDYMSLS
2710 2720 2730 2740 2750
EQLRKQIRSA AKKNNIPFRL TCATTRQVVN VITTKISLKG GKIISTWFKL
2760 2770 2780 2790 2800
MLKATLLCVL AALFCYVIMP VHILSAHDGY TNEIIGYKAI QDGVTRDIVP
2810 2820 2830 2840 2850
TDDCFANKHA GFDTWFSQRG GSYRNDKNCP VVAAIITREI GFIVPGLPGT
2860 2870 2880 2890 2900
VLRAINGDFL HFLPRVFSAV GNICYTPSKL IEYSDFATSA CVLAAECTIF
2910 2920 2930 2940 2950
KDAMGKPVPY CYDTNLLEGS ISYSELRPDT RYVLMDGSII QFPNTYLEGS
2960 2970 2980 2990 3000
VRVVTTFDAE YCRHGTCERS EAGICLSTSG RWVLNNEHYR ALPGVFCGVD
3010 3020 3030 3040 3050
AMNLIANIFT PLVQPVGALD VSASVVAGGI IAILVTCAAY YFMKFRRAFG
3060 3070 3080 3090 3100
EYNHVVAANA LLFLMSFTIL CLAPAYSFLP GVYSVFYLYL TFYFTNDVSF
3110 3120 3130 3140 3150
LAHLQWFAMF SPIVPFWITA IYVFCISLKH CHWFFNNYLR KRVMFNGVTF
3160 3170 3180 3190 3200
STFEEAALCT FLLNKEMYLK LRSETLLPLT QYNRYLALYN KYKYFSGALD
3210 3220 3230 3240 3250
TTSYREAACC HLAKALNDFS NSGSDVLYQP PQTSITSAVL QSGFRKMAFP
3260 3270 3280 3290 3300
SGKVEGCMVQ VTCGTTTLNG LWLDDTVYCP RHVICTAEDM LNPNYEDLLI
3310 3320 3330 3340 3350
RKSNHSFLVQ AGNVQLRVIG HSMQNCLLRL KVDTSNPKTP KYKFVRIQPG
3360 3370 3380 3390 3400
QTFSVLACYN GSPSGVYQCA MRPNHTIKGS FLNGSCGSVG FNIDYDCVSF
3410 3420 3430 3440 3450
CYMHHMELPT GVHAGTDLEG KFYGPFVDRQ TAQAAGTDTT ITLNVLAWLY
3460 3470 3480 3490 3500
AAVINGDRWF LNRFTTTLND FNLVAMKYNY EPLTQDHVDI LGPLSAQTGI
3510 3520 3530 3540 3550
AVLDMCAALK ELLQNGMNGR TILGSTILED EFTPFDVVRQ CSGVTFQGKF
3560 3570 3580 3590 3600
KKIVKGTHHW VLLTFLTSLL ILVQSTQWSL FFFVYENAFL PFTLGIMAIA
3610 3620 3630 3640 3650
ACAMLLVKHK HAFLCLFLLP SLATVAYFNM VYMPASWVMR IMTWLELADT
3660 3670 3680 3690 3700
SLSGYRLKDC VMYASALVLL VLMTARTVYD DAARRVWTLM NVITLVYKVY
3710 3720 3730 3740 3750
YGNALDQAIS MWALVISVTS NYSGVVTTIM FLARAVVFVC VEYYPLLFIT
3760 3770 3780 3790 3800
GNTLQCIMLV YCFLGYCCCC YFGLFCLLNR YFRLTLGVYD YLVSTQEFRY
3810 3820 3830 3840 3850
MNSQGLLPPK SSIDAFKLNI KLLGIGGKPC IKVATVQSKM SDVKCTSVVL
3860 3870 3880 3890 3900
LSVLQQLRVE SSSKLWAQCV QLHNDILLAK DTTEAFEKMV SLLSVLLSMQ
3910 3920 3930 3940 3950
GAVDINKLCE EMLDNRATLQ AIASEFSSLP SYAAYATAQE AYEQAVANGD
3960 3970 3980 3990 4000
SEVVLKKLKK CLNVAKSEFD RDAAMQRKLE KMADQAMTQM YKQARSEDKR
4010 4020 4030 4040 4050
AKVTSAMQTM LFTMLRKLDN DALNNIINNA RDGCVPLNII PLTTAAKLMV
4060 4070 4080 4090 4100
VVPDYGTYKN TCDGNTFTYA SALWEIQQVV DADSKIVQLS EINMDNSPNL
4110 4120 4130 4140 4150
AWPLIVTALR ANSAVKLQNN ELSPVALRQM SCAAGTTQTA CTDDNALAYY
4160 4170 4180 4190 4200
NNSKGGRFVL ALLSDHQDLK WARFPKSDGS GTIYTELEPP CRFVTDTPKG
4210 4220 4230 4240 4250
PKVKYLYFIK GLNNLNRGMV LGSLAATVRL QAGNATEVPA NSTVLSFCAF
4260 4270 4280 4290 4300
AVDPAKAYKD YLASGGQPIT NCVKMLCTHT GTGQAITVTP EANMDQESFG
4310 4320 4330 4340 4350
GASCCLYCRC HIDHPNPKGF CDLKGKYVQI PTTCANDPVG FTLRNTVCTV
4360 4370 4380
CGMWKGYGCS CDQLREPMMQ SADASTFLNG FAV
Length:4,383
Mass (Da):486,433
Last modified:September 18, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9782823D85081CD
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JX993988 Genomic RNA Translation: AGC74171.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX993988 Genomic RNA Translation: AGC74171.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR9QTH2_SARS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R9QTH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2013
Last sequence update: September 18, 2013
Last modified: February 10, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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