UniProtKB - R9QE65 (R9QE65_HUMAN)
Protein
Signal transducer and activator of transcription
Gene
STAT2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- signal transduction Source: InterPro
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcriptionUniRule annotation |
Gene namesi | Name:STAT2Imported ORF Names:hCG_24995Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170581.13 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinUniRule annotationARBA annotationProteomic databases
MaxQBi | R9QE65 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170581, Expressed in oviduct epithelium and 220 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 572 – 667 | SH2InterPro annotationAdd BLAST | 96 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 149 – 169 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OMAi | FTIKYTY |
OrthoDBi | 327469at2759 |
Family and domain databases
CDDi | cd10373, SH2_STAT2, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR022756, STAT2_C IPR035854, STAT2_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12188, STAT2_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
R9QE65-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG
60 70 80 90 100
SDDSKATMLF FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQPFSQD
110 120 130 140 150
PTQLAEMIFN LLLEEKRILI QAQRAQLEQG EPVLETPVES QQHEIESRIL
160 170 180 190 200
DLRAMMEKLV KSISQLKDQQ DVFCFRYKIQ AKGKTPSLDP HQTKEQKILQ
210 220 230 240 250
ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKA QQQKACIRAP
260 270 280 290 300
IDHGLEQLET WFTAGAKLLF HLRQLLKELK GLSCLVSYQD DPLTKGVDLR
310 320 330 340 350
NAQVTELLQR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL
360 370 380 390 400
QEGNESLTVE VSIDRNPPQL QGFRKFNILT SNQKTLTPEK GQSQGLIWDF
410 420 430 440 450
GYLTLVEQRS GGSGKGSNKG PLGVTEELHI ISFTVKYTYQ GLKQELKTDT
460 470 480 490 500
LPVVIISNMN QLSIAWASVL WFNLLSPNLQ NQQFFSNPPK APWSLLGPAL
510 520 530 540 550
SWQFSSYVGR GLNSDQLSML RNKLFGQNCR TEDPLLSWAD FTKRESPPGK
560 570 580 590 600
LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERRLL KKTMSGTFLL
610 620 630 640 650
RFSESSEGGI TCSWVEHQDD DKVLIYSVQP YTKEVLQSLP LTEIIRHYQL
660 670 680 690 700
LTEENIPENP LRFLYPRIPR DEAFGCYYQE KVNLQERRKY LKHRLIVVSN
710 720 730 740 750
RQVDELQQPL ELKPEPELES LELELGLVPE PELSLDLEPL LKAGLDLGPE
760 770 780 790 800
LESVLESTLE PVIEPTLCMV SQTVPEPDQG PVSQPVPEPD LPCDLRHLNT
810 820 830 840 850
EPMEIFRNCV KIEEIMPNGD PLLAGQNTVD EVYVSRPSHF YTDGPLMPSD
F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JX178204 Genomic DNA Translation: AFM91192.1 JX178205 Genomic DNA Translation: AFM91193.1 JX178206 Genomic DNA Translation: AFM91194.1 JX178208 Genomic DNA Translation: AFM91197.1 JX178209 Genomic DNA Translation: AFM91198.1 JX178210 Genomic DNA Translation: AFM91199.1 JX178211 Genomic DNA Translation: AFM91200.1 JX178213 Genomic DNA Translation: AFM91202.1 JX178214 Genomic DNA Translation: AFM91203.1 JX178215 Genomic DNA Translation: AFM91204.1 JX178216 Genomic DNA Translation: AFM91205.1 JX178217 Genomic DNA Translation: AFM91206.1 JX178218 Genomic DNA Translation: AFM91207.1 JX178219 Genomic DNA Translation: AFM91208.1 JX178220 Genomic DNA Translation: AFM91209.1 JX178223 Genomic DNA Translation: AFM91212.1 JX178224 Genomic DNA Translation: AFM91213.1 JX178225 Genomic DNA Translation: AFM91214.1 JX178227 Genomic DNA Translation: AFM91216.1 JX178232 Genomic DNA Translation: AFM91221.1 JX178234 Genomic DNA Translation: AFM91223.1 JX178236 Genomic DNA Translation: AFM91225.1 JX178237 Genomic DNA Translation: AFM91226.1 JX178238 Genomic DNA Translation: AFM91227.1 JX178239 Genomic DNA Translation: AFM91228.1 JX178240 Genomic DNA Translation: AFM91229.1 JX178241 Genomic DNA Translation: AFM91230.1 JX178242 Genomic DNA Translation: AFM91231.1 JX178243 Genomic DNA Translation: AFM91232.1 JX178245 Genomic DNA Translation: AFM91234.1 JX178246 Genomic DNA Translation: AFM91235.1 JX178247 Genomic DNA Translation: AFM91236.1 JX178249 Genomic DNA Translation: AFM91238.1 JX178250 Genomic DNA Translation: AFM91239.1 JX178251 Genomic DNA Translation: AFM91240.1 JX178252 Genomic DNA Translation: AFM91241.1 JX178254 Genomic DNA Translation: AFM91243.1 JX178255 Genomic DNA Translation: AFM91244.1 JX178256 Genomic DNA Translation: AFM91245.1 JX178257 Genomic DNA Translation: AFM91246.1 JX178258 Genomic DNA Translation: AFM91247.1 JX178260 Genomic DNA Translation: AFM91249.1 JX178262 Genomic DNA Translation: AFM91251.1 JX178263 Genomic DNA Translation: AFM91252.1 JX178264 Genomic DNA Translation: AFM91253.1 JX178266 Genomic DNA Translation: AFM91255.1 JX178269 Genomic DNA Translation: AFM91258.1 JX178273 Genomic DNA Translation: AFM91262.1 CH471054 Genomic DNA Translation: EAW96934.1 CH471054 Genomic DNA Translation: EAW96935.1 CH471054 Genomic DNA Translation: EAW96937.1 |
RefSeqi | NP_005410.1, NM_005419.3 |
Genome annotation databases
GeneIDi | 6773 |
KEGGi | hsa:6773 |
UCSCi | uc001slc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JX178204 Genomic DNA Translation: AFM91192.1 JX178205 Genomic DNA Translation: AFM91193.1 JX178206 Genomic DNA Translation: AFM91194.1 JX178208 Genomic DNA Translation: AFM91197.1 JX178209 Genomic DNA Translation: AFM91198.1 JX178210 Genomic DNA Translation: AFM91199.1 JX178211 Genomic DNA Translation: AFM91200.1 JX178213 Genomic DNA Translation: AFM91202.1 JX178214 Genomic DNA Translation: AFM91203.1 JX178215 Genomic DNA Translation: AFM91204.1 JX178216 Genomic DNA Translation: AFM91205.1 JX178217 Genomic DNA Translation: AFM91206.1 JX178218 Genomic DNA Translation: AFM91207.1 JX178219 Genomic DNA Translation: AFM91208.1 JX178220 Genomic DNA Translation: AFM91209.1 JX178223 Genomic DNA Translation: AFM91212.1 JX178224 Genomic DNA Translation: AFM91213.1 JX178225 Genomic DNA Translation: AFM91214.1 JX178227 Genomic DNA Translation: AFM91216.1 JX178232 Genomic DNA Translation: AFM91221.1 JX178234 Genomic DNA Translation: AFM91223.1 JX178236 Genomic DNA Translation: AFM91225.1 JX178237 Genomic DNA Translation: AFM91226.1 JX178238 Genomic DNA Translation: AFM91227.1 JX178239 Genomic DNA Translation: AFM91228.1 JX178240 Genomic DNA Translation: AFM91229.1 JX178241 Genomic DNA Translation: AFM91230.1 JX178242 Genomic DNA Translation: AFM91231.1 JX178243 Genomic DNA Translation: AFM91232.1 JX178245 Genomic DNA Translation: AFM91234.1 JX178246 Genomic DNA Translation: AFM91235.1 JX178247 Genomic DNA Translation: AFM91236.1 JX178249 Genomic DNA Translation: AFM91238.1 JX178250 Genomic DNA Translation: AFM91239.1 JX178251 Genomic DNA Translation: AFM91240.1 JX178252 Genomic DNA Translation: AFM91241.1 JX178254 Genomic DNA Translation: AFM91243.1 JX178255 Genomic DNA Translation: AFM91244.1 JX178256 Genomic DNA Translation: AFM91245.1 JX178257 Genomic DNA Translation: AFM91246.1 JX178258 Genomic DNA Translation: AFM91247.1 JX178260 Genomic DNA Translation: AFM91249.1 JX178262 Genomic DNA Translation: AFM91251.1 JX178263 Genomic DNA Translation: AFM91252.1 JX178264 Genomic DNA Translation: AFM91253.1 JX178266 Genomic DNA Translation: AFM91255.1 JX178269 Genomic DNA Translation: AFM91258.1 JX178273 Genomic DNA Translation: AFM91262.1 CH471054 Genomic DNA Translation: EAW96934.1 CH471054 Genomic DNA Translation: EAW96935.1 CH471054 Genomic DNA Translation: EAW96937.1 |
RefSeqi | NP_005410.1, NM_005419.3 |
3D structure databases
SMRi | R9QE65 |
ModBasei | Search... |
Proteomic databases
MaxQBi | R9QE65 |
Protocols and materials databases
Antibodypediai | 3552, 988 antibodies |
Genome annotation databases
GeneIDi | 6773 |
KEGGi | hsa:6773 |
UCSCi | uc001slc.4, human |
Organism-specific databases
CTDi | 6773 |
EuPathDBi | HostDB:ENSG00000170581.13 |
Phylogenomic databases
OMAi | FTIKYTY |
OrthoDBi | 327469at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6773, 4 hits in 866 CRISPR screens |
ChiTaRSi | STAT2, human |
GenomeRNAii | 6773 |
Gene expression databases
Bgeei | ENSG00000170581, Expressed in oviduct epithelium and 220 other tissues |
Family and domain databases
CDDi | cd10373, SH2_STAT2, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR022756, STAT2_C IPR035854, STAT2_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12188, STAT2_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R9QE65_HUMAN | |
Accessioni | R9QE65Primary (citable) accession number: R9QE65 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 18, 2013 |
Last sequence update: | September 18, 2013 | |
Last modified: | December 2, 2020 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |