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Entry version 61 (10 Feb 2021)
Sequence version 1 (24 Jul 2013)
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Protein
Submitted name:

Multiple epidermal growth factor-like domains protein 8

Gene

Megf8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multiple epidermal growth factor-like domains protein 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Megf8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
621190, Megf8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2592 – 2614HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500448822828 – 2789Sequence analysisAdd BLAST2762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 57PROSITE-ProRule annotation
Disulfide bondi142 ↔ 152PROSITE-ProRule annotation
Disulfide bondi174 ↔ 184PROSITE-ProRule annotation
Disulfide bondi193 ↔ 202PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1191PROSITE-ProRule annotation
Disulfide bondi1194 ↔ 1208PROSITE-ProRule annotation
Disulfide bondi1233 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1245 ↔ 1259PROSITE-ProRule annotation
Disulfide bondi1435 ↔ 1444PROSITE-ProRule annotation
Disulfide bondi2217 ↔ 2226PROSITE-ProRule annotation
Disulfide bondi2229 ↔ 2243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000052687, Expressed in frontal cortex and 21 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
R9PXW3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 140CUBInterPro annotationAdd BLAST111
Domaini138 – 168EGF-likeInterPro annotationAdd BLAST31
Domaini170 – 203EGF-likeInterPro annotationAdd BLAST34
Domaini1074 – 1115EGF-likeInterPro annotationAdd BLAST42
Domaini1163 – 1210Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1211 – 1261Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1263 – 1405CUBInterPro annotationAdd BLAST143
Domaini1403 – 1445EGF-likeInterPro annotationAdd BLAST43
Domaini2122 – 2160EGF-likeInterPro annotationAdd BLAST39
Domaini2197 – 2245Laminin EGF-likeInterPro annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2466 – 2508DisorderedSequence analysisAdd BLAST43
Regioni2762 – 2789DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2616 – 2636Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2468 – 2486Pro-richSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationARBA annotation, Kelch repeatARBA annotation, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160262

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000612_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMYGGLS

Database of Orthologous Groups

More...
OrthoDBi
49565at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 4 hits
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

R9PXW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGGALAAA LALAFAVLGP LSHKVLAGDC KGQRQVLREA PGFVTDGAGN
60 70 80 90 100
YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPQGPLLA
110 120 130 140 150
SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQNHG
160 170 180 190 200
QCKSPGVCVC EPGWGGPDCG LQECSAYCGS HGTCASTLGP CRCEPGFLGR
210 220 230 240 250
ACDLHLWENQ GAGWWHSVSA GDPAFSARVG AAGAFLSPPG LLAVFGGQDL
260 270 280 290 300
NKALGDLVLY NFSTNTWESW DLTPAPAARH SHVAVAWAGF LVLMGGELAN
310 320 330 340 350
GLLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDDIWLYVS
360 370 380 390 400
GGRTQHDLFS SGLFRFRLDH TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS
410 420 430 440 450
RTLLVHGGHR PSTARFSVRV NSTELFHVDR RVWTTLKGRD GLQGPRERAF
460 470 480 490 500
HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP
510 520 530 540 550
GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF
560 570 580 590 600
QAPALDYHLD YCSMYTDHSV CSRDPECSWC QGACQSAPPP GTPSGACPAA
610 620 630 640 650
SCLGLGRLLS DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR
660 670 680 690 700
GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV
710 720 730 740 750
SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWARAQR
760 770 780 790 800
LHVLARMARG PDTENMEEVG RWVAQQEKET RRLQRPGSSR LFPLPGRGNK
810 820 830 840 850
YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSLACSS
860 870 880 890 900
YSSCLGCLAD QGCGWCLNSA TCHLRQGRAH CEDDGNGESL LVLVPALCPL
910 920 930 940 950
CEEHRDCHAC TQDPFCEWHQ STNRKGDAAC SRRGRGRGAL KNPEECPPLC
960 970 980 990 1000
SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE
1010 1020 1030 1040 1050
PRCRSCHGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS
1060 1070 1080 1090 1100
LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC
1110 1120 1130 1140 1150
HCQRGYQGDG ITHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP
1160 1170 1180 1190 1200
APGPPAPRCS RDCGCNFHSH CRRRGPGYCD ECQDWTWGEH CERCRPGSFG
1210 1220 1230 1240 1250
NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQICSPGYY
1260 1270 1280 1290 1300
GDPRAGGSCF RECGGRALLT NVSSVALGSR RFGGLLPPGG GTARAGPGLS
1310 1320 1330 1340 1350
YCVWVVSATE ALQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF
1360 1370 1380 1390 1400
LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA
1410 1420 1430 1440 1450
SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP
1460 1470 1480 1490 1500
ENCNAHTGAG ICNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS
1510 1520 1530 1540 1550
ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT
1560 1570 1580 1590 1600
QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GITCDFWVLN
1610 1620 1630 1640 1650
LTTLQWRQEK APQSIELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL
1660 1670 1680 1690 1700
EYQLATGTWV SGAQSGTPPT GLYGHSAVYH EATDSLYVFG GFRFHVELAA
1710 1720 1730 1740 1750
PSPELYSLHC PDRTWSLLAP SQGAKPRPRL FHASALLGDT MVVLGGRSDP
1760 1770 1780 1790 1800
DEFSSDVLLY QVNCNTWLLP DLTRPAFVGS PMEESVAHAV AAVGSRLYIS
1810 1820 1830 1840 1850
GGFGGVALGR LLALTLPPDP CRLLPSPEAC NQSGACTWCH GACLSGDQAH
1860 1870 1880 1890 1900
RLGCGVPPCS PMPRSPEECR RLRTCSECLA RHPRTLQPGD GEASVPRCKW
1910 1920 1930 1940 1950
CTNCPEGACI GRNGSCTSEN DCRINQREVF WAGNCSEAAC GAADCEQCTR
1960 1970 1980 1990 2000
EGKCMWTRQF KRTGETRRIL SVQPTYDWTC FSHSLLNVSP MPVESSPPLP
2010 2020 2030 2040 2050
CPTPCHLLPN CTSCLASKGA DGGWQHCVWS SSLQQCLSPS YLPLRCMAGG
2060 2070 2080 2090 2100
CGRLLRGPES CSLGCAQATQ CALCLRRPHC GWCAWGGQDG GGHCMEGGLS
2110 2120 2130 2140 2150
GPRDGLTCGR PGASWAFLSC PPEDECANGH HDCNETQNCH DQPHGYECSC
2160 2170 2180 2190 2200
KTGYTMDNVT GVCRPVCAQG CVNGSCVEPD HCRCHFGFVG RNCSTECRCN
2210 2220 2230 2240 2250
RHSECAGVGA RDHCLLCRNH TKGSHCEQCL PLFVGSALGG GTCRPCHAFC
2260 2270 2280 2290 2300
RGNSHVCVSR KELEMARREP EKYSLDPEEI EAWVAEGPSE DEAVCVNCQN
2310 2320 2330 2340 2350
NSYGDRCESC LHGYFLLDGK CTKCQCNGHA DTCNEQDGTG CPCQNNTETG
2360 2370 2380 2390 2400
VCQGSSPSDR RDCYKYQCAK CRESFHGSPL GGQQCYRLIS VEQECCLDPT
2410 2420 2430 2440 2450
SQTNCFHEPK RRALGPGRTV LFGVQPKFTN VDIRLTLDVT FGAVDLYVST
2460 2470 2480 2490 2500
SYDTFVVRVA PDTGVHTVHI QPPPPPPPPP PPADGVPRVA SDLGGLGTGS
2510 2520 2530 2540 2550
GSGSPVEPRV REVWPRGLIT YVTVTEPSAV LVVRSVRDRL VITYPHEHHA
2560 2570 2580 2590 2600
LKSSRFYLLL LGVGDPNGPG ANGSADSQGL LFFRQDQAHI DLFVFFSVFF
2610 2620 2630 2640 2650
SCFFLFLSLC VLLWKAKQAL DQRQEQRRHL QEMTKMASRP FAKVTVCFPP
2660 2670 2680 2690 2700
DPAGPAPAWK PAGLPPPAFR RSEPFLAPLL LTGAGGPWGP MGGGCCPPAL
2710 2720 2730 2740 2750
PATTAGLRAG PITLEPTEDG MAGVATLLLQ LPGGPHAPNG ACLGSALVTL
2760 2770 2780
RHRLHEYCGG SGGAGGSGHG GGGGRKGLLS QDNLTSMSL
Length:2,789
Mass (Da):297,611
Last modified:July 24, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B054090B041C768
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QYP0MEGF8_RAT
Multiple epidermal growth factor-li...
Megf8 Egfl4
2,788Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC121639 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_446080.1, NM_053628.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000077313; ENSRNOP00000074834; ENSRNOG00000052687

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114029

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:114029

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121639 Genomic DNA No translation available.
RefSeqiNP_446080.1, NM_053628.2

3D structure databases

SMRiR9PXW3
ModBaseiSearch...

Genome annotation databases

EnsembliENSRNOT00000077313; ENSRNOP00000074834; ENSRNOG00000052687
GeneIDi114029
KEGGirno:114029

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1954
RGDi621190, Megf8

Phylogenomic databases

GeneTreeiENSGT00940000160262
HOGENOMiCLU_000612_0_0_1
OMAiWMYGGLS
OrthoDBi49565at2759

Gene expression databases

BgeeiENSRNOG00000052687, Expressed in frontal cortex and 21 other tissues

Family and domain databases

CDDicd00041, CUB, 1 hit
Gene3Di2.120.10.80, 4 hits
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR9PXW3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R9PXW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: February 10, 2021
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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