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UniProtKB - R9PXW3 (R9PXW3_RAT)

Entry version 61 (10 Feb 2021)
Sequence version 1 (24 Jul 2013)
Previous versions | rss
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Protein
Submitted name:

Multiple epidermal growth factor-like domains protein 8

Gene

Megf8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multiple epidermal growth factor-like domains protein 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Megf8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...RGDi		621190, Megf8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2592 – 2614HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500448822828 – 2789Sequence analysisAdd BLAST2762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 57PROSITE-ProRule annotation
Disulfide bondi142 ↔ 152PROSITE-ProRule annotation
Disulfide bondi174 ↔ 184PROSITE-ProRule annotation
Disulfide bondi193 ↔ 202PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1191PROSITE-ProRule annotation
Disulfide bondi1194 ↔ 1208PROSITE-ProRule annotation
Disulfide bondi1233 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1245 ↔ 1259PROSITE-ProRule annotation
Disulfide bondi1435 ↔ 1444PROSITE-ProRule annotation
Disulfide bondi2217 ↔ 2226PROSITE-ProRule annotation
Disulfide bondi2229 ↔ 2243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000052687, Expressed in frontal cortex and 21 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		R9PXW3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 140CUBInterPro annotationAdd BLAST111
Domaini138 – 168EGF-likeInterPro annotationAdd BLAST31
Domaini170 – 203EGF-likeInterPro annotationAdd BLAST34
Domaini1074 – 1115EGF-likeInterPro annotationAdd BLAST42
Domaini1163 – 1210Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1211 – 1261Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1263 – 1405CUBInterPro annotationAdd BLAST143
Domaini1403 – 1445EGF-likeInterPro annotationAdd BLAST43
Domaini2122 – 2160EGF-likeInterPro annotationAdd BLAST39
Domaini2197 – 2245Laminin EGF-likeInterPro annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2466 – 2508DisorderedSequence analysisAdd BLAST43
Regioni2762 – 2789DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2616 – 2636Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2468 – 2486Pro-richSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationARBA annotation, Kelch repeatARBA annotation, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160262

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000612_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		WMYGGLS

Database of Orthologous Groups

More...OrthoDBi		49565at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 4 hits
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

R9PXW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGGALAAA LALAFAVLGP LSHKVLAGDC KGQRQVLREA PGFVTDGAGN 
        60         70         80         90        100
YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPQGPLLA 
       110        120        130        140        150
SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQNHG 
       160        170        180        190        200
QCKSPGVCVC EPGWGGPDCG LQECSAYCGS HGTCASTLGP CRCEPGFLGR 
       210        220        230        240        250
ACDLHLWENQ GAGWWHSVSA GDPAFSARVG AAGAFLSPPG LLAVFGGQDL 
       260        270        280        290        300
NKALGDLVLY NFSTNTWESW DLTPAPAARH SHVAVAWAGF LVLMGGELAN 
       310        320        330        340        350
GLLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDDIWLYVS 
       360        370        380        390        400
GGRTQHDLFS SGLFRFRLDH TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS 
       410        420        430        440        450
RTLLVHGGHR PSTARFSVRV NSTELFHVDR RVWTTLKGRD GLQGPRERAF 
       460        470        480        490        500
HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP 
       510        520        530        540        550
GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF 
       560        570        580        590        600
QAPALDYHLD YCSMYTDHSV CSRDPECSWC QGACQSAPPP GTPSGACPAA 
       610        620        630        640        650
SCLGLGRLLS DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR 
       660        670        680        690        700
GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV 
       710        720        730        740        750
SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWARAQR 
       760        770        780        790        800
LHVLARMARG PDTENMEEVG RWVAQQEKET RRLQRPGSSR LFPLPGRGNK 
       810        820        830        840        850
YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSLACSS 
       860        870        880        890        900
YSSCLGCLAD QGCGWCLNSA TCHLRQGRAH CEDDGNGESL LVLVPALCPL 
       910        920        930        940        950
CEEHRDCHAC TQDPFCEWHQ STNRKGDAAC SRRGRGRGAL KNPEECPPLC 
       960        970        980        990       1000
SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE 
      1010       1020       1030       1040       1050
PRCRSCHGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS 
      1060       1070       1080       1090       1100
LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC 
      1110       1120       1130       1140       1150
HCQRGYQGDG ITHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP 
      1160       1170       1180       1190       1200
APGPPAPRCS RDCGCNFHSH CRRRGPGYCD ECQDWTWGEH CERCRPGSFG 
      1210       1220       1230       1240       1250
NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQICSPGYY 
      1260       1270       1280       1290       1300
GDPRAGGSCF RECGGRALLT NVSSVALGSR RFGGLLPPGG GTARAGPGLS 
      1310       1320       1330       1340       1350
YCVWVVSATE ALQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF 
      1360       1370       1380       1390       1400
LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA 
      1410       1420       1430       1440       1450
SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP 
      1460       1470       1480       1490       1500
ENCNAHTGAG ICNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 
      1510       1520       1530       1540       1550
ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT 
      1560       1570       1580       1590       1600
QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GITCDFWVLN 
      1610       1620       1630       1640       1650
LTTLQWRQEK APQSIELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL 
      1660       1670       1680       1690       1700
EYQLATGTWV SGAQSGTPPT GLYGHSAVYH EATDSLYVFG GFRFHVELAA 
      1710       1720       1730       1740       1750
PSPELYSLHC PDRTWSLLAP SQGAKPRPRL FHASALLGDT MVVLGGRSDP 
      1760       1770       1780       1790       1800
DEFSSDVLLY QVNCNTWLLP DLTRPAFVGS PMEESVAHAV AAVGSRLYIS 
      1810       1820       1830       1840       1850
GGFGGVALGR LLALTLPPDP CRLLPSPEAC NQSGACTWCH GACLSGDQAH 
      1860       1870       1880       1890       1900
RLGCGVPPCS PMPRSPEECR RLRTCSECLA RHPRTLQPGD GEASVPRCKW 
      1910       1920       1930       1940       1950
CTNCPEGACI GRNGSCTSEN DCRINQREVF WAGNCSEAAC GAADCEQCTR 
      1960       1970       1980       1990       2000
EGKCMWTRQF KRTGETRRIL SVQPTYDWTC FSHSLLNVSP MPVESSPPLP 
      2010       2020       2030       2040       2050
CPTPCHLLPN CTSCLASKGA DGGWQHCVWS SSLQQCLSPS YLPLRCMAGG 
      2060       2070       2080       2090       2100
CGRLLRGPES CSLGCAQATQ CALCLRRPHC GWCAWGGQDG GGHCMEGGLS 
      2110       2120       2130       2140       2150
GPRDGLTCGR PGASWAFLSC PPEDECANGH HDCNETQNCH DQPHGYECSC 
      2160       2170       2180       2190       2200
KTGYTMDNVT GVCRPVCAQG CVNGSCVEPD HCRCHFGFVG RNCSTECRCN 
      2210       2220       2230       2240       2250
RHSECAGVGA RDHCLLCRNH TKGSHCEQCL PLFVGSALGG GTCRPCHAFC 
      2260       2270       2280       2290       2300
RGNSHVCVSR KELEMARREP EKYSLDPEEI EAWVAEGPSE DEAVCVNCQN 
      2310       2320       2330       2340       2350
NSYGDRCESC LHGYFLLDGK CTKCQCNGHA DTCNEQDGTG CPCQNNTETG 
      2360       2370       2380       2390       2400
VCQGSSPSDR RDCYKYQCAK CRESFHGSPL GGQQCYRLIS VEQECCLDPT 
      2410       2420       2430       2440       2450
SQTNCFHEPK RRALGPGRTV LFGVQPKFTN VDIRLTLDVT FGAVDLYVST 
      2460       2470       2480       2490       2500
SYDTFVVRVA PDTGVHTVHI QPPPPPPPPP PPADGVPRVA SDLGGLGTGS 
      2510       2520       2530       2540       2550
GSGSPVEPRV REVWPRGLIT YVTVTEPSAV LVVRSVRDRL VITYPHEHHA 
      2560       2570       2580       2590       2600
LKSSRFYLLL LGVGDPNGPG ANGSADSQGL LFFRQDQAHI DLFVFFSVFF 
      2610       2620       2630       2640       2650
SCFFLFLSLC VLLWKAKQAL DQRQEQRRHL QEMTKMASRP FAKVTVCFPP 
      2660       2670       2680       2690       2700
DPAGPAPAWK PAGLPPPAFR RSEPFLAPLL LTGAGGPWGP MGGGCCPPAL 
      2710       2720       2730       2740       2750
PATTAGLRAG PITLEPTEDG MAGVATLLLQ LPGGPHAPNG ACLGSALVTL 
      2760       2770       2780 
RHRLHEYCGG SGGAGGSGHG GGGGRKGLLS QDNLTSMSL
Length:2,789
Mass (Da):297,611
Last modified:July 24, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B054090B041C768
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QYP0MEGF8_RAT
Multiple epidermal growth factor-li...
Megf8 Egfl4
2,788Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC121639 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_446080.1, NM_053628.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000077313; ENSRNOP00000074834; ENSRNOG00000052687

Database of genes from NCBI RefSeq genomes

More...GeneIDi		114029

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:114029

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121639 Genomic DNA No translation available.
RefSeqiNP_446080.1, NM_053628.2

3D structure databases

SMRiR9PXW3
ModBaseiSearch...

Genome annotation databases

EnsembliENSRNOT00000077313; ENSRNOP00000074834; ENSRNOG00000052687
GeneIDi114029
KEGGirno:114029

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1954
RGDi621190, Megf8

Phylogenomic databases

GeneTreeiENSGT00940000160262
HOGENOMiCLU_000612_0_0_1
OMAiWMYGGLS
OrthoDBi49565at2759

Gene expression databases

BgeeiENSRNOG00000052687, Expressed in frontal cortex and 21 other tissues

Family and domain databases

CDDicd00041, CUB, 1 hit
Gene3Di2.120.10.80, 4 hits
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR9PXW3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R9PXW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: February 10, 2021
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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