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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Leptospira yanagawae serovar Saopaulo str. Sao Paulo = ATCC 700523
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk_2), Pyruvate kinase (pyk_1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei201ATPUniRule annotation1
Binding sitei292ATP; via carbonyl oxygenUniRule annotation1
Binding sitei323ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 352ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processGlycolysisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotationSAAS annotation (EC:2.7.2.3UniRule annotationSAAS annotation)
Gene namesi
Name:pgkUniRule annotationImported
ORF Names:LEP1GSC202_3418Imported
OrganismiLeptospira yanagawae serovar Saopaulo str. Sao Paulo = ATCC 700523Imported
Taxonomic identifieri1249483 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000013996 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

R8ZPK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLPLLEEQN LKGKRVFVRV DFNVPVENGI ATDKTRIEKT LPTLELLISK
60 70 80 90 100
GAKIILGSHL GRPKGGPEPK FSMKPVFDVL ATLVKTKVSF SESVIGAGVV
110 120 130 140 150
KLSNELGEGE ILLLENLRFH KEEEANDPSF CKELAKLADV YVNDAFGTAH
160 170 180 190 200
RAHASTEGVA HLLPAFAGLL MRKEIEVLSG LLARPERPFV AIVGGSKVSS
210 220 230 240 250
KFAILKNLLE KVDHLLIGGG MAYTFLKSRA VPVGKSLVEP EFESQAFQLI
260 270 280 290 300
DRAGVQGVDL QIPIDHIIAD NFDPNAKTKS VDKMGIIDGW MGMDIGPKTI
310 320 330 340 350
DNYVKAIKEA KTILWNGPMG VFEMDKFSKG TIEIAKAISK SKAKTVVGGG
360 370 380 390
DSIAAVNKAG VADKITHIST GGGASLEFLE GRTLPGVQCL LPKEEK
Length:396
Mass (Da):42,657
Last modified:July 24, 2013 - v1
Checksum:i88AD995C3CEABC17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AOGX02000024 Genomic DNA Translation: EOQ87939.1
RefSeqiWP_015677970.1, NZ_AOGX02000024.1

Genome annotation databases

EnsemblBacteriaiEOQ87939; EOQ87939; LEP1GSC202_3418

Similar proteinsi

Entry informationi

Entry nameiR8ZPK2_9LEPT
AccessioniPrimary (citable) accession number: R8ZPK2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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