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Protein

General transcription factor IIH subunit 4

Gene

CHC_T00007214001

Organism
Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
ORF Names:CHC_T00007214001Imported
OrganismiChondrus crispus (Carrageen Irish moss) (Polymorpha crispa)Imported
Taxonomic identifieri2769 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeRhodymeniophycidaeGigartinalesGigartinaceaeChondrus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144
OMAiYLEQYAH
PhylomeDBiR7QRW5

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

R7QRW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSDSAPGLS QSIFEDLADA AAKSKRLITR LYESPHAVQC VFRALPPIAR
60 70 80 90 100
LYVARIIYLP SNQEVSVDSF RQCLRRRQRA YDRHDSAILA LKALHVLVEV
110 120 130 140 150
ETLVDGPGRK ETRLQLNDKF AENLRRSVTY GVEPVFGGPC EDIEMVDVES
160 170 180 190 200
REVVTKKMDE FSAAKLDRIL NFLVESNGSN APGGTVVQAL AQVGILESKS
210 220 230 240 250
IGLCITSSGF QFLLKDSFAQ LWVLLRSIVN TQFRGEELDA WELIFKLSFA
260 270 280 290 300
CPGKEYRDPH LSKCQRELMA ELHELGIVRL GEDATFRPTT VGVRLLTSAS
310 320 330 340 350
RIQSGPASTA DASSMVKIAG EIEIFVETNF RVYAYTTSNF QTNLLALFTH
360 370 380 390 400
MRYKLPSMVV GHLTRDAVRR ALMSGITGDQ IIGYLNAHAH PRMKRGVIPS
410 420 430 440 450
NVSDEIRLWE AEQDRVQTTP GVLLSDFESQ EAFEKVMSYA YDLGASVWSD
460 470
RDRLKVIVAR EAYGSVRGFM NSNDLH
Length:476
Mass (Da):53,260
Last modified:July 24, 2013 - v1
Checksum:i7BAE3B0CC20B67B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG002185 Genomic DNA Translation: CDF40468.1
RefSeqiXP_005710762.1, XM_005710705.1

Genome annotation databases

EnsemblPlantsiCDF40468; CDF40468; CHC_T00007214001
GeneIDi17318484
GrameneiCDF40468; CDF40468; CHC_T00007214001
KEGGiccp:CHC_T00007214001

Similar proteinsi

Entry informationi

Entry nameiR7QRW5_CHOCR
AccessioniPrimary (citable) accession number: R7QRW5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: February 28, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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