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UniProtKB - R4KWC4 (R4KWC4_DANRE)

Entry version 45 (02 Dec 2020)
Sequence version 1 (24 Jul 2013)
Previous versions | rss
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Protein
Submitted name:

RING finger E3 ubiquitin-protein ligase transcript variant 5

Gene

rnf111

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-DRE-5696395, Formation of Incision Complex in GG-NER
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RING finger E3 ubiquitin-protein ligase transcript variant 5Imported (EC:6.3.2.-Imported)
Submitted name:
Ring finger protein 111Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rnf111Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070808-2, rnf111

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000078802, Expressed in mature ovarian follicle and 28 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini980 – 1021RING-typeInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 180DisorderedSequence analysisAdd BLAST180
Regioni256 – 291DisorderedSequence analysisAdd BLAST36
Regioni348 – 372DisorderedSequence analysisAdd BLAST25
Regioni399 – 473DisorderedSequence analysisAdd BLAST75
Regioni493 – 563DisorderedSequence analysisAdd BLAST71
Regioni644 – 748DisorderedSequence analysisAdd BLAST105
Regioni944 – 974DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 76PolyampholyteSequence analysisAdd BLAST23
Compositional biasi108 – 122PolyampholyteSequence analysisAdd BLAST15
Compositional biasi123 – 151PolarSequence analysisAdd BLAST29
Compositional biasi159 – 176PolarSequence analysisAdd BLAST18
Compositional biasi399 – 471PolarSequence analysisAdd BLAST73
Compositional biasi495 – 534PolarSequence analysisAdd BLAST40
Compositional biasi644 – 664PolarSequence analysisAdd BLAST21
Compositional biasi671 – 687PolarSequence analysisAdd BLAST17
Compositional biasi688 – 713Pro-richSequence analysisAdd BLAST26
Compositional biasi720 – 735Pro-richSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Arkadia family.ARBA annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157691

Database of Orthologous Groups

More...OrthoDBi		1098052at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029306, RNF111_N
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15303, RNF111_N, 1 hit
PF13639, zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

R4KWC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSEISADAR QKQEPLKGPL ANPEPMETAK SFPAEMEVIG KAGSDFTSPL 
        60         70         80         90        100
CAETRHRPSR DAGGRRDCER GLSGRKKRKS QQPGPSYCSL KEAPMSEATL 
       110        120        130        140        150
TPPRHRPMLL ETRSEDERNP ESSLSDCASS PSSSLRFGDS DTLSSDEDGM 
       160        170        180        190        200
PMTVRQQLKA HGAASTGSTG SSTGTAVGIR PLLARTRASR SHKWARLEPD 
       210        220        230        240        250
SNHVKRPCLG SRRPLHRKRF VKGGAGGVTQ RTPKQKERLL LQRKKREVIA 
       260        270        280        290        300
RKKYALLHST SSSSEEMTSD DSSPSSTEAE HELYVDVNSS SSQASTAAVA 
       310        320        330        340        350
SGVLDEDVVV IEATPAPAVP ASEEINVTST DSEVEIVTVG DAFRPRSVGG 
       360        370        380        390        400
HGRMHWGPSC SQSRAQEGRG RHRLSTVIQP LRQSAGEVVD LTVDEDDLSV 
       410        420        430        440        450
VPTTSDSTHP QPVSSSSSSS SRNACTSASP QEGPGPSSSC SAAAPDSTLA 
       460        470        480        490        500
AQSHGGVPRS GTTNTTATED ESRRSLLGEN GGVAMPRLPS CCPQHSPCSG 
       510        520        530        540        550
PSSGHLSMGH THSGCMQSGA TQQSGPPQPG SQHSHTHSHH FHHHHHTAPV 
       560        570        580        590        600
PSSLAYQESS CPLERPTAMP APCGGVSNQY HDQTLPVDLS SSAVRSSGSS 
       610        620        630        640        650
STGFHGTSAF DPCCPGSASR PPVYVSQAAP GPSQQTVADS FSPTIVAQPQ 
       660        670        680        690        700
PQPPQLSSCR HYMHPTYGSL SRPLHHQSSS SCPHSHSNAP PPQQPPPQGD 
       710        720        730        740        750
YVIPHPVLPF HTPLPTHAPG HTVPTAPPPS LPSHHLPGSS APLPQHLPPE 
       760        770        780        790        800
HQALQHHLPV LGPNSVQRLH HHDLLQRMEV QRRRMMQHPT RAHERPPPHP 
       810        820        830        840        850
HRMHPNYGHG HHIHVPQTMS SLPRQSDQRT TWELGIEAGV TVAPYPSGHL 
       860        870        880        890        900
HPHLPHYHPP PRLHHFPIQL MHTGSMPEVT YPHIRYISSR MTFGRTYEDL 
       910        920        930        940        950
LHLEERLGTV NRGASQGTIE RCTYPHKYKK KVVERDTEEQ LAPEAWASVG 
       960        970        980        990       1000
KKMHSTSNSR KLHGKQEEEE GAEEDTEEKC TICLSILEEG EDVRRLPCMH 
      1010       1020       1030 
LFHQLCVDQW LLTNKKCPIC RVDIEAQLSS ES
Length:1,032
Mass (Da):111,963
Last modified:July 24, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6D3F0D4BD723268
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
N0A274N0A274_DANRE
RING finger protein 111 transcript ...
rnf111
1,003Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4L6W8R4L6W8_DANRE
RING finger E3 ubiquitin-protein li...
rnf111
995Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QWE1F1QWE1_DANRE
Ring finger protein 111
rnf111
1,004Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL935053 Genomic DNA No translation available.
BX664728 Genomic DNA No translation available.
KC556912 mRNA Translation: AGL08235.1

NCBI Reference Sequences

More...RefSeqi		NP_001268922.1, NM_001281993.1
XP_005168981.1, XM_005168924.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000173789; ENSDARP00000142775; ENSDARG00000078802

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100151141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:100151141

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935053 Genomic DNA No translation available.
BX664728 Genomic DNA No translation available.
KC556912 mRNA Translation: AGL08235.1
RefSeqiNP_001268922.1, NM_001281993.1
XP_005168981.1, XM_005168924.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000173789; ENSDARP00000142775; ENSDARG00000078802
GeneIDi100151141
KEGGidre:100151141

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54778
ZFINiZDB-GENE-070808-2, rnf111

Phylogenomic databases

GeneTreeiENSGT00940000157691
OrthoDBi1098052at2759

Enzyme and pathway databases

ReactomeiR-DRE-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-DRE-5696395, Formation of Incision Complex in GG-NER
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSDARG00000078802, Expressed in mature ovarian follicle and 28 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR029306, RNF111_N
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF15303, RNF111_N, 1 hit
PF13639, zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR4KWC4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R4KWC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: December 2, 2020
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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