Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - R4JK63 (R4JK63_9ALPC)

Entry version 53 (02 Dec 2020)
Sequence version 1 (24 Jul 2013)
Previous versions | rss
Add a publicationFeedback
Protein

3C-like proteinase

Gene
N/A
Organism
Porcine epidemic diarrhea virus
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.ARBA annotation
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.ARBA annotation
Nsp9 is a ssRNA-binding protein.ARBA annotation
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.ARBA annotation
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.ARBA annotation
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, ExonucleaseARBA annotation, HelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virusARBA annotation, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion, Viral RNA replicationARBA annotation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.19.12ARBA annotation, EC:3.6.4.12ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
ExoribonucleaseARBA annotation
Growth factor-like peptideARBA annotation
HelicaseARBA annotation
M-PROARBA annotation
NendoUARBA annotation
Non-structural protein 1ARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
ORF1ab polyproteinARBA annotation
PL1-PRO/PL2-PROARBA annotation
PLP1/PLP2ARBA annotation
Papain-like proteinases 1/2ARBA annotation
Peptide HD2ARBA annotation
Putative 2'-O-methyl transferaseARBA annotation
RNA-directed RNA polymeraseARBA annotation
Replicase polyprotein 1abARBA annotation
Uridylate-specific endoribonucleaseARBA annotation
nsp12ARBA annotation
nsp15ARBA annotation
nsp16ARBA annotation
nsp5ARBA annotation
p12ARBA annotation
p195ARBA annotation
p23ARBA annotation
p34ARBA annotation
p5ARBA annotation
p87ARBA annotation
p9ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorcine epidemic diarrhea virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28295 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Alphacoronavirus › Pedacovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000096014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1964 – 1982HelicalSequence analysisAdd BLAST19
Transmembranei2025 – 2044HelicalSequence analysisAdd BLAST20
Transmembranei2104 – 2125HelicalSequence analysisAdd BLAST22
Transmembranei2132 – 2153HelicalSequence analysisAdd BLAST22
Transmembranei2165 – 2185HelicalSequence analysisAdd BLAST21
Transmembranei2528 – 2546HelicalSequence analysisAdd BLAST19
Transmembranei2787 – 2804HelicalSequence analysisAdd BLAST18
Transmembranei2859 – 2887HelicalSequence analysisAdd BLAST29
Transmembranei3337 – 3354HelicalSequence analysisAdd BLAST18
Transmembranei3361 – 3381HelicalSequence analysisAdd BLAST21
Transmembranei3401 – 3419HelicalSequence analysisAdd BLAST19
Transmembranei3431 – 3449HelicalSequence analysisAdd BLAST19
Transmembranei3469 – 3493HelicalSequence analysisAdd BLAST25
Transmembranei3500 – 3520HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		R4JK63

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1057 – 1296Peptidase C16InterPro annotationAdd BLAST240
Domaini1286 – 1465MacroInterPro annotationAdd BLAST180
Domaini1691 – 1951Peptidase C16InterPro annotationAdd BLAST261
Domaini2998 – 3299Peptidase C30InterPro annotationAdd BLAST302
Domaini5028 – 5111CV ZBDInterPro annotationAdd BLAST84
Domaini5275 – 5636(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST362

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1011 – 1042DisorderedSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd18808, SF1_C_Upf1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 2 hits
3.40.50.11580, 1 hit
3.90.70.90, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043609, CoV_NSP15_C
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR027352, CV_ZBD
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR009466, NSP14_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR009461, NSP16_CoV-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR011050, Pectin_lyase_fold/virulence
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR001205, RNA-dir_pol_C
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13087, AAA_12, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 2 hits
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 2 hits
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF51126, SSF51126, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits
PS51657, PSRV_HELICASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

R4JK63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNQVTLAF ANDAEISAFG FCTASEAVSY YSEAAASGFM QCRFVSFDLA 
        60         70         80         90        100
DTVEGLLPED YVMVVVGTTK LSAYVDTFGS RPRNICGWLL FSNCNYILEE 
       110        120        130        140        150
LELTFGRRGG NIVPVDQYMC GADGKPVLQE SEWEYTDFFA DSEDGQLNIA 
       160        170        180        190        200
GITYVKAWIV ERSDVSYASQ NLTSIKSITY CSTYEHTFPD GTAMKVARTP 
       210        220        230        240        250
KIKKTVVLSE PLATIYREIG SPFVDNGSDA RSIIKRPVFL HAFVKCKCGS 
       260        270        280        290        300
YHWTVGDWTS YVSTCCGFKC KPVLVASCSA TPGSVVVTRA GAGTGVKYYN 
       310        320        330        340        350
NMFLRHVADI DGLAFWRILK VQSKDDLACS GKFIEHHEEG FTDPCYFLND 
       360        370        380        390        400
SSIATKLKFD ILSGKFSDEV KQAIFAGHVV VGSALVDIVD DALGQPWFIR 
       410        420        430        440        450
KLGDLASAAW EQLKAVVRGL NLLSDXVVFF GKRLSCATLS IVNGVFEFIT 
       460        470        480        490        500
EVPEKLAAAV TVFVNFLNEL FESACDCLKV GGKTFNKVGS YVLFDNALVK 
       510        520        530        540        550
LVKAKVRGPR QAGVCEVRYT SLVIGSTTKV VSKRVENANV NLVVVDEDVT 
       560        570        580        590        600
LNTTGRTVVV DGLAFFESDG FYRHLADADV VIEHPVYKSA CELKPFFECD 
       610        620        630        640        650
PIPDFPMPVA ASVAELCVQT DLLLKNYNTP YKTYSCVVRG DKCCITCTLH 
       660        670        680        690        700
ITAPSYMEDA ANFVDLCTKN IGTAGFHEFY ITAHEQQDLQ GFVTTCCTMS 
       710        720        730        740        750
GFECFMPTIP QCPAVLEEID GGSIWRSFIT GLNTMWDFCK HLKVSFGLDG 
       760        770        780        790        800
IVVTVARKFK RLGALLAEMY NTYLSTVVEN LVLAGVSFKY YATSVPKIVF 
       810        820        830        840        850
GCCFHSVKSV LASAFQIPVQ AGIEKFKVFL NCVHPVVPRV IETSFVELEE 
       860        870        880        890        900
TTFKPPALNG SIAIVDGFAF YYDGTLYYPT DGNSVVPICF KKKGGGDVKF 
       910        920        930        940        950
SDEVSVRTID PVYKVSLEFE FESETIMAVL NKAVGNRIKV TGGWDDVVEY 
       960        970        980        990       1000
INVAIEVLKD HIDVPKYYIY DEEGGTDPNL PVMVSQWPLN DDTISQDLLD 
      1010       1020       1030       1040       1050
VEVVTDAPID FEGDEVDSSD PDKVADVANS EPEDDGPNVA PETNVESEVE 
      1060       1070       1080       1090       1100
EVAATLSFIK DTPSTVTKDP FAFDFASYGG LKVLRQSHNN CWVTSTLVQL 
      1110       1120       1130       1140       1150
QLLGIVDDPA MELFSAGRVG PMVRKCYESQ KAILGSLGDV SACLESLTKD 
      1160       1170       1180       1190       1200
LHTLKITCSV VCGCGTGERI YEGCAFRMTP TLEPFPYGAC AQCAQVLMHT 
      1210       1220       1230       1240       1250
FKSIVGTGIF CRDTTALSLD SLVVKPLCAA AFIGKDSGHY VTNFYDAAMA 
      1260       1270       1280       1290       1300
IDGCGRHQIK YDTLNTICVK DVNWTAPFVP DVEPVLDPVV KPFYSYKNVD 
      1310       1320       1330       1340       1350
FYQGDFSDLV KLPCDFVVNA ANENLSHGGG IAKAIDVYTK GMLQKCSNDY 
      1360       1370       1380       1390       1400
IKAHGPIKVG RGVMLDALGL KVFNVVGPRK GKHAPELLVK AYKSVFANSG 
      1410       1420       1430       1440       1450
VALTPLISVG IFSVPLEESL SAFLACVGDR HCKCFCYSDK EREATINYMD 
      1460       1470       1480       1490       1500
GLVDAIFKDA LVDTTPVQED VQQVSKKPVL PNFEPFRIEG AHAFYECNPE 
      1510       1520       1530       1540       1550
GLMSLGADKL VLFTNSNLDF CSVGKCLNNV TGGALLEAIN VFKKSNKTVP 
      1560       1570       1580       1590       1600
AGNCVTFECA YMISITMVVL PSDGDANYDK NYARAVVKVS KLKGKLLLAV 
      1610       1620       1630       1640       1650
GDATLYSKLS HLSVVGFVST PDDVERFYAN KSVVIKVTED TRSVKAVKVE 
      1660       1670       1680       1690       1700
STVTYGQQIG PCLVNDTVVT DNKPVVADVV AKVVPSANWD SHYGFDKAGE 
      1710       1720       1730       1740       1750
FHMLDHTGFA FPSEVVNGRR VLKTTDNNCW VNVTCLQLQF ARFRFKSAGL 
      1760       1770       1780       1790       1800
QAMWESYCTG DVAMFVHWLY WLTGVDKGQP SDSENALNML SKYIVSAGSV 
      1810       1820       1830       1840       1850
TIERVTHDGC CCSKRVVTAP VVNASVLKLG VEDGLCPHGF NYIDKVVVVK 
      1860       1870       1880       1890       1900
GTTIVVNVGK PVLAPSHLFL KGVSYTTFLD NGNGVVGHYT VFDHDTGMVH 
      1910       1920       1930       1940       1950
DGDAFVPGDL NVSPVTNVVV SEQTAVVIKD PVKKVELDAT KLLDTMNYAS 
      1960       1970       1980       1990       2000
ERFFSFGDFM SRNLITVFLY ILSILGLCFR AFRKRDVKVL AGVPQRTGII 
      2010       2020       2030       2040       2050
LRKSVRYNAK ALSVFFKLKL YWFKVLGKFS LGIYALYALL FMTIRFTPIG 
      2060       2070       2080       2090       2100
GPVCDDVVAG YANSSFDKNE YCNSVICKVC LYGYQELSDF SHTQVVWQHL 
      2110       2120       2130       2140       2150
RDPLIGNVMP FFYLAFLAIF GGVYVKAITL YFIFQYLNIL GVFLGLQQSI 
      2160       2170       2180       2190       2200
WFLQLVPFDV FGDEIVVFFI VTRVLMFLKH VFLGCDKASC VACSKSARLK 
      2210       2220       2230       2240       2250
RVPVQTIFQG TSKSFYVYAN GGSKFCKKHN FFCLNCDSYG PGCTFINDVI 
      2260       2270       2280       2290       2300
ATEVGNVVKL NVQPTGPATI LIDKVEFSNG FYYLYSGDTF WKYNFDITDS 
      2310       2320       2330       2340       2350
KYTCKESLKN CSIITDFIVF NNNGSNVNQV KNACVYFSQM LCKPVKLVDS 
      2360       2370       2380       2390       2400
ALLASLSVDF GASLHSAFVS VLSNSFGKDL SSCNDMQDCK STLGFDDVPL 
      2410       2420       2430       2440       2450
DTFNAAVAEA HRYDVLLTDM SFNNFTTSYA KPEEKLPVHD IATCMRVGAK 
      2460       2470       2480       2490       2500
IVNHNVLVKD SIPVVWLVRD FIALSEETRK YIIRTTKVKG ITFMLTFNDC 
      2510       2520       2530       2540       2550
RMHTTIPTVC IANKKGAGLP SFLKVKKFFW FLCLFIVAVF FSLSFLDFST 
      2560       2570       2580       2590       2600
QVSSDSDYDF KYIESGQLKT FDNPLSCVHN VFNNFDQWHD AKFGFTPVNN 
      2610       2620       2630       2640       2650
PSCPIVVGVS DEARTVPGIP AGVYLAGKTL VFAINTIFGT SGLCFDASGV 
      2660       2670       2680       2690       2700
ADKGACIFNS ACTTLSGLGG TAVYCYKNGL VEGAKLYSEL APHSYYKMVD 
      2710       2720       2730       2740       2750
GNAVSLPEII SRGFGIRTIR TKAMTYCRVG QCVQSAEGVC FGADRFFVYN 
      2760       2770       2780       2790       2800
AESGSDFVCG TGLFTLLMNV ISVFSKTVPV TVLSGQILFN CIIAFAAVAV 
      2810       2820       2830       2840       2850
CFLFTKFKRM FGDMSVGVFT VGACTLLNNV SYIVTQNTLG MLGYATLYFL 
      2860       2870       2880       2890       2900
CTKGVRYMWI WHLGFLISYI LIAPWWVLMV YAFSAIFEFM PNLFKLKVST 
      2910       2920       2930       2940       2950
QLFEGDKFVG SFENAAAGTF VLDMHAYERL ANSISTEKLR QYASTYNKYK 
      2960       2970       2980       2990       3000
YYSGSASEAD YRLACFAHLA KAMMDYASNH NDTLYTPPTV SYNSTLQAGL 
      3010       3020       3030       3040       3050
RKMAQPSGVV EKCIVRVCYG NMALNGLWLG DTVMCPRHVI ASSTTSTIDY 
      3060       3070       3080       3090       3100
DYALSVLRLH NFSISSGNVF LGVVGVTMRG ALLQIKVNQN NVHTPKYTYR 
      3110       3120       3130       3140       3150
TVRPGESFNI LACYDGAAAG VYGVNMRSNY TIRGSFINGA CGSPGYNINN 
      3160       3170       3180       3190       3200
GTVEFCYLHQ LELGSGCHVG SDLDGVMYGG YEDQPTLQVE GASSLFTENV 
      3210       3220       3230       3240       3250
LAFLYAALIN GSTWWLSSSR IAVDRFNEWA VHNGMTTVVN TDCFSILAAK 
      3260       3270       3280       3290       3300
TGVDVQRLLA SIQSLHKNFG GKQILGYTSL TDEFTTGEVI RQMYGVNLQS 
      3310       3320       3330       3340       3350
GYVSRACRNV LLVGSFLTFF WSELVSYTKF FWVNPGYVTP MFACLSLLSS 
      3360       3370       3380       3390       3400
LLMFTLKHKT LFFQVFLIPA LIVTSCINLA FDVEVYNYLA EHFDYHVSLM 
      3410       3420       3430       3440       3450
GFNAQGLVNI FVCFVVTILH GTYTWRFFNT PVSSVTYVVA LLTAAYNYFY 
      3460       3470       3480       3490       3500
ASDILSCAMT LFASVTGNWF VGAVCYKAAV YMALRFPTFV AIFGDIKSVM 
      3510       3520       3530       3540       3550
FCYLVLGYFT CCFYGILYWF NRFFKVSVGV YDYTVSAAEF KYMVANGLRA 
      3560       3570       3580       3590       3600
PTGTLDSLLL SAKLIGIGGE RNIKISSVQS KLTDIKCSNV VLLGCLSSMN 
      3610       3620       3630       3640       3650
VSANSTEWAY CVDLHNKINL CNDPEKAQEM LLALLAFFLS KNSAFGLDDL 
      3660       3670       3680       3690       3700
LESYFNDNSM LQSVASTYVG LPSYVIYENA RQQYEDAVNN GSPPQLVKQL 
      3710       3720       3730       3740       3750
RHAMNVAKSE FDREASTQRK LDRMAEQAAA QMYKEARAVN RKSKVVSAMH 
      3760       3770       3780       3790       3800
SLLFGMLRRL DMSSVDTILN LAKDGVVPLS VIPAVSATKL NIVTSDIDSY 
      3810       3820       3830       3840       3850
NRIQREGCVH YAGTIWNIID IKDNDGKVVH VKEVTAQNAE SLSWPLVLGC 
      3860       3870       3880       3890       3900
ERIVKLQNNE IIPGKLKQRS IKAEGDGIVG EGKALYNNEG GRTFMYAFIS 
      3910       3920       3930       3940       3950
DKPDLRVVKW EFDGGCNTIE LEPPRKFLVD SPNGAQIKYL YFVRNLNTLR 
      3960       3970       3980       3990       4000
RGAVLGYIGA TVRLQAGKQT EQAINSSLLT LCAFAVDPAK TYIDAVKSGH 
      4010       4020       4030       4040       4050
KPVGNCVKML ANGSGNGQAV TNGVEASTNQ DSYGGASVCL YCRAHVEHPS 
      4060       4070       4080       4090       4100
MDGFCRLKGK YVQVPLGTVD PIRFVLENDV CKVCGCWLAN GCTCDRSIMQ 
      4110       4120       4130       4140       4150
STDYGLFKRV RGSSAARLEP CNGTDAQHVY RAFDIYNKDV ACLGKFLKVN 
      4160       4170       4180       4190       4200
CVRLKNLDKH DAFYVVKRCT KSVMEHEQSI YSRLEKCGAV AEHDFFTWKD 
      4210       4220       4230       4240       4250
GRAIYGNVCR KDLTEYTMMD LCYALRNFDE NNCDVLKSIL IKVGACEESY 
      4260       4270       4280       4290       4300
FNNKVWFDPV ENEDIHRVYA LLGTIVSRAM LKCVKFCDAM VEQGIVGVVT 
      4310       4320       4330       4340       4350
LDNQDLNGDF YDFGDFTCSI KGMGIPICTS YYSYMMPVMG MTNCLASECF 
      4360       4370       4380       4390       4400
VKSDIFGEDF KSYDLLEYDF TEHKTALFNK YFKYWGLQYH PNCVDCSDEQ 
      4410       4420       4430       4440       4450
CIVHCANFNT LFSTTIPITA FGPLCRKCWI DGVPLVTTAG YHFKQLGIVW 
      4460       4470       4480       4490       4500
NNDLNLHSSR LSINELLQFC SDPALLIASS PALVDQRTVC FSVAALGTGM 
      4510       4520       4530       4540       4550
TNQTVKPGHF NKEFYDFLLE QGFFSEGSEL TLNHFFFAQK GDAAVKDFDY 
      4560       4570       4580       4590       4600
YRYNRPTVLD ICQARVVYQI VQRYFDIYEG GCITAKEVVV TNLNKSAGYP 
      4610       4620       4630       4640       4650
LNKFGKAGLY YESLSYEEQD ELYAYTKRNI LPTMTQLNLK YAISGKDRAR 
      4660       4670       4680       4690       4700
TVGGVSLLST MTTRQYHQKH LKSIVNTRGA SVVIGTTKFY GGWDNMLKNL 
      4710       4720       4730       4740       4750
IDGVENPCLM GWDYPKCDRA LPNMIRMISA MILGSKHTTC CSSTDRFFRL 
      4760       4770       4780       4790       4800
CNELAQVLTE VVYSNGGFYL KPGGTTSGDA TTAYANSVFN IFQAVSANVN 
      4810       4820       4830       4840       4850
KLLSVDSNVC HNLEVKQLQR KLYDCCYRST TVDDQFVVEY YGYLRKHFSM 
      4860       4870       4880       4890       4900
MILSDDGVVC YNNDYASLGY VADLNAFKAV LYYQNNVFMS ASKCWIEPDI 
      4910       4920       4930       4940       4950
NKGPHEFCSQ HTMQIVDKDG TYYLPYPDPS RILSAGVFVD DVVKTDAVVL 
      4960       4970       4980       4990       5000
LERYVSLAID AYPLSKHENP EYKKVFYVLL DWVKHLYKTL NAGVLESFSV 
      5010       5020       5030       5040       5050
TLLEDSTAKF WDESFYANMY EKSAVLQSAG LCVVCGSQTV LRCGDCLRRP 
      5060       5070       5080       5090       5100
MLCTKCAYDH VIGTTHKFIL AITPYVCCAS DCGVNDVTKL YLGGLSYWCH 
      5110       5120       5130       5140       5150
DHKPRLAFPL CSAGNVFGLY KNSATGSPDV EDFNRIATSD WTDVSDYRLA 
      5160       5170       5180       5190       5200
NDVKDSLRLF AAETIKAKEE SVKSSYACAT LHEVVGPKEL LLKWEVGRPK 
      5210       5220       5230       5240       5250
PPLNRNSVFT CYHITKNTKF QIGEFVFEKA EYDNDAVTYK TTATTKLVPG 
      5260       5270       5280       5290       5300
MVFVLTSHNV QPLRAPTIAN QERYSTIHKL HPAFNIPEAY SSLVPYYQLI 
      5310       5320       5330       5340       5350
GKQKITTIQG PPGSGKSHCV IGLGLYYPGA RIVFTACSHA AVDSLCVKAS 
      5360       5370       5380       5390       5400
TAYSNDKCSR IIPQRARVEC YDGFKSNNTS AQYLFSTVNA LPECNADIVV 
      5410       5420       5430       5440       5450
VDEVSMCTNY DLSVINQRIS YRHVVYVGDP QQLPAPRVMI SRGTLEPKDY 
      5460       5470       5480       5490       5500
NVVTQRMCAL KPDVFLHKCY RCPAEIVRTV SEMVYENQFI PVHPDSKQCF 
      5510       5520       5530       5540       5550
KIFCKGNVQV DNGSSINRRQ LDVVRMFLAK NPRWSKAVFI SPYNSQNYVA 
      5560       5570       5580       5590       5600
SRVLGLQIQT VDSSQGSEYD YVIYTQTSDT AHACNVNRFN VAITRAKKGI 
      5610       5620       5630       5640       5650
LCIMCDRSLF DVLKFFELKL SDLQANEGCG LFKDCSRGDD LLPPSHANTF 
      5660       5670       5680       5690       5700
MSLADNFKTD QDLAVQIGVN GPIKYEHAIS FMGFRFDINI PNHHTLFCTR 
      5710       5720       5730       5740       5750
DFAMRNVRGW LGFDVEGAHV VGSNVGTNVP LQLGFSNGVD FVVRPEGCVV 
      5760       5770       5780       5790       5800
TESGDYIKPV RARAPPGEQF AHLLPLLKRG QPWDVVRKRI VQMCSDYLAN 
      5810       5820       5830       5840       5850
LSDILIFVLW AGGLELTTMR YFVKIGPSKS CDCGKVATCY NSALHTYCCF 
      5860       5870       5880       5890       5900
KHALGCDYLY NPYCIDIQQW GYKGSLSLNH HEHCNVHRNE HVASGDAIMT 
      5910       5920       5930       5940       5950
RCLAIHDCFV KNVDWSITYP FIGDEAVINK IGRIVQSHTM RSVLKLYNPK 
      5960       5970       5980       5990       6000
AIYDIGNPKG IRCAVTDAKW FCFDKNPTNS NVKTLEYDYI THGQFDGLCL 
      6010       6020       6030       6040       6050
FWNCNVDMYP EFSVVCRFDT RCRSPLNLEG CNGGSLYVNN HAFHTPAFDK 
      6060       6070       6080       6090       6100
RAFAKLKPMP FFFYDDTECD KLQDSINYVP LRASNCITKC NVGGAVCSKH 
      6110       6120       6130       6140       6150
CAMYHSYVNA YNTFTSAGFT IWVPTSFDTY NLWQTFSNNL QGLENIAFNV 
      6160       6170       6180       6190       6200
VKKGSFVGVE GELPVAVVND KVLVRDGTVD TLVFTNKTSL PTNVAFELYA 
      6210       6220       6230       6240       6250
KRKVGLTPPI TILRNLGVVC TSKCVIWDYE AERPLTTFTK DVCKYTDFEG 
      6260       6270       6280       6290       6300
DVCTLFDNSI VGSLERFSMT QNAVLMSLTA VKKLTGIKLT YGYLNGVPVN 
      6310       6320       6330       6340       6350
THEDKPFTWY IYTRKNGKFE DYSDGYFTQG RTTADFSPRS DMEKDFLSMD 
      6360       6370       6380       6390       6400
MGLFINKYGL EDYGFEHVVY GDVSKTTLGG LHLLISQVRL SCMGVLKIDE 
      6410       6420       6430       6440       6450
FVSSNDSTLK SCTVTYADNP SSKMVCTYMD LLLDDFVSIL KSLDLSVVSK 
      6460       6470       6480       6490       6500
VHEVMVDCKM WRWMLWCKDH KLQTFYPQLQ ASEWKCGYSM PSIYKIQRMC 
      6510       6520       6530       6540       6550
LEPCNLYNYG AGINLPDGIM FNVVKYTQLC QYLNSTTMCV PHHMRVLHLG 
      6560       6570       6580       6590       6600
AGSDKGVAPG TAVLRRWLPL DAIIVDNDSV DYVSDADYSV TGDCSTLYLS 
      6610       6620       6630       6640       6650
DKFDLVISDM YDGKIKSCDG ENVSKEGFFP YINGVITEKL ALGGTVAIKV 
      6660       6670       6680       6690       6700
TEFSWNKKLY ELIQKFEYWT MFCTSVNTSS SEAFLIGVHY LGDFASGAVI 
      6710       6720       6730       6740       6750
DGNTMHANYI FWRNSTIMTM SYNSVLDLSK FNCKHKATVV INLKDSSISD 
      6760       6770       6780 
VVLGLLKNGK LLVRNNDAIC GFSNHLVNVN K
Length:6,781
Mass (Da):753,504
Last modified:July 24, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC856E0FCDA96A6A4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KC140102 Genomic RNA Translation: AGK89913.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC140102 Genomic RNA Translation: AGK89913.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZUHX-ray2.39A/B2998-3296[»]
5ZQGX-ray1.60A/B2998-3296[»]
SMRiR4JK63
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 2 hits
3.40.50.11580, 1 hit
3.90.70.90, 2 hits
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043609, CoV_NSP15_C
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR027352, CV_ZBD
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR009466, NSP14_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR009461, NSP16_CoV-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR011050, Pectin_lyase_fold/virulence
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR001205, RNA-dir_pol_C
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF13087, AAA_12, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 2 hits
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 2 hits
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF51126, SSF51126, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits
PS51657, PSRV_HELICASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR4JK63_9ALPC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R4JK63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: December 2, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again