UniProtKB - R4HIW0 (R4HIW0_9MUSC)
Protein
NADH-ubiquinone oxidoreductase chain 2
Gene
N/A
Organism
Stegana xishuangbanna
Status
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation
Catalytic activityi
- EC:7.1.1.2UniRule annotationARBA annotation
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
GO - Biological processi
- mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Keywordsi
Molecular function | TranslocaseUniRule annotationARBA annotation |
Biological process | Electron transport, Respiratory chainUniRule annotation, Transport |
Ligand | NADUniRule annotationARBA annotation, UbiquinoneUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase chain 2UniRule annotation (EC:7.1.1.2UniRule annotation) |
Encoded oni | MitochondrionImported |
Organismi | Stegana xishuangbannaImported |
Taxonomic identifieri | 1091605 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Stegana › Steganina |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 28 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 60 – 80 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 92 – 115 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 121 – 142 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 149 – 167 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 196 – 216 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 236 – 255 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 275 – 298 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 318 – 341 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 286 | Proton_antipo_MInterPro annotationAdd BLAST | 263 | |
Domaini | 287 – 338 | NADH_dehy_S2_CInterPro annotationAdd BLAST | 52 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR010933, NADH_DH_su2_C IPR003917, NADH_UbQ_OxRdtase_chain2 IPR001750, ND/Mrp_mem |
Pfami | View protein in Pfam PF06444, NADH_dehy_S2_C, 1 hit PF00361, Proton_antipo_M, 1 hit |
PRINTSi | PR01436, NADHDHGNASE2 |
i Sequence
Sequence statusi: Complete.
R4HIW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNNSSKILF VIIMMSGSLI TVTSNSWLGA WMGLEINLLS FIPLMSDNNN
60 70 80 90 100
LMSTEASLKY FLVQALASTV LLFAVILMMM KNNINYEINF SFYITMIILS
110 120 130 140 150
SLLLKSGAAP FHFWFPNIME GLSWMNCLML MTWQKIAPLM LISHVNIKLL
160 170 180 190 200
LFSSIIMSVI IGSLGGLNQS SLRKLMAFSS INHLGWMLMA LNSNETIWFI
210 220 230 240 250
YFLMYSFLSF ILTFMFNNFK IFHFNQMFSL FFNSKILKFI LFMNFLSLGG
260 270 280 290 300
LPPFLGFLPK WLVIQQLSME NQYFMLMILV MSTLITLFFY LRICYSAFML
310 320 330 340
NYYENNWLIN MQMKSMNYNL YLIMSFFSIF GLMLISILYF ML
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JF416725 Genomic DNA Translation: AEQ03941.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JF416725 Genomic DNA Translation: AEQ03941.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
InterProi | View protein in InterPro IPR010933, NADH_DH_su2_C IPR003917, NADH_UbQ_OxRdtase_chain2 IPR001750, ND/Mrp_mem |
Pfami | View protein in Pfam PF06444, NADH_dehy_S2_C, 1 hit PF00361, Proton_antipo_M, 1 hit |
PRINTSi | PR01436, NADHDHGNASE2 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R4HIW0_9MUSC | |
Accessioni | R4HIW0Primary (citable) accession number: R4HIW0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 24, 2013 |
Last sequence update: | July 24, 2013 | |
Last modified: | February 10, 2021 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |