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UniProtKB - R4GNB1 (R4GNB1_HUMAN)
Protein
Submitted name:
Beta-alanine-activating enzyme
Gene
AASDH
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- organic substance metabolic process Source: UniProt
Keywordsi
Biological process | Lipid metabolismARBA annotation |
Ligand | Nucleotide-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Beta-alanine-activating enzymeImported |
Gene namesi | Name:AASDHImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23993, AASDH |
VEuPathDBi | HostDB:ENSG00000157426 |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 436 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
PhosphopantetheinePROSITE-ProRule annotationProteomic databases
PeptideAtlasi | R4GNB1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157426, Expressed in kidney epithelium and 213 other tissues |
ExpressionAtlasi | R4GNB1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 400 – 477 | CarrierInterPro annotationAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00440000033811 |
HOGENOMi | CLU_010423_0_0_1 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR036736, ACP-like_sf IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR009081, PP-bd_ACP IPR025666, PQQ-like_dom IPR018391, PQQ_beta_propeller_repeat IPR002372, PQQ_repeat IPR011047, Quinoprotein_ADH-like_supfam IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF00550, PP-binding, 1 hit PF13360, PQQ_2, 1 hit PF13570, PQQ_3, 1 hit |
SMARTi | View protein in SMART SM00564, PQQ, 6 hits |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit PS50075, CARRIER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
R4GNB1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNDGKEKYE KEKIKSISSE HVNEEKAEEH MDLRLKHCLA YVLHTSGTTG
60 70 80 90 100
IPKIVRVPHK CIVPNIQHFR VLFDITQEDV LFLASPLTFD PSVVEIFLAL
110 120 130 140 150
SSGASLLIVP TSVKLLPSKL ASVLFSHHRV TVLQATPTLL RRFGSQLIKS
160 170 180 190 200
TVLSATTSLR VLALGGEAFP SLTVLRSWRG EGNKTQIFNV YGITEVSSWA
210 220 230 240 250
TIYRIPEKTL NSTLKCELPV QLGFPLLGTV VEVRDTNGFT IQEGSGQVFL
260 270 280 290 300
GGRNRVCFLD DEVTVPLGTM RATGDFVTVK DGEIFFLGRK DSQIKRHGKR
310 320 330 340 350
LNIELVQQVA EELQQVESCA VTWYNQEKLI LFMVSKDASV KEYIFKELQK
360 370 380 390 400
YLPSHAVPDE LVLIDSLPFT SHGKIDVSEL NKIYLNYINL KSENKLSGKE
410 420 430 440 450
DLWEKLQYLW KSTLNLPEDL LRVPDESLFL NSGGDSLKSI RLLSEIEKLV
460 470 480 490 500
GTSVPGLLEI ILSSSILEIY NHILQTVVPD EDVTFRKSCA TKRKLSDINQ
510 520 530 540 550
EEASGTSLHQ KAIMTFTCHN EINAFVVLSR GSQILSLNST RFLTKLGHCS
560 570 580 590 600
SACPSDSVSQ TNIQNLKGLN SPVLIGKSKD PSCVAKVSEE GKPAIGTQKM
610 620 630 640 650
ELHVRWRSDT GKCVDASPLV VIPTFDKSST TVYIGSHSHR MKAVDFYSGK
660 670 680 690 700
VKWEQILGDR IESSACVSKC GNFIVVGCYN GLVYVLKSNS GEKYWMFTTE
710 720 730 740 750
DAVKSSATMD PTTGLIYIGS HDQHAYALDI YRKKCVWKSK CGGTVFSSPC
760 770 780 790 800
LNLIPHHLYF ATLGGLLLAV NPATGNVIWK HSCGKPLFSS PQCCSQYICI
810 820 830 840 850
GCVDGNLLCF THFGEQVWQF STSGPIFSSP CTSPSEQKIF FGSHDCFIYC
860 870 880 890 900
CNMKGHLQWK FETTSRVYAT PFAFHNYNGS NEMLLAAAST DGKVWILESQ
910 920 930 940
SGQLQSVYEL PGEVFSSPVV LESMLIIGCR DNYVYCLDLL GGNQK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ4L235 | ACSF4_HUMAN | Beta-alanine-activating enzyme | AASDH ACSF4, U26, HSPC318 | 1,098 | Annotation score: | ||
D6RJA2 | D6RJA2_HUMAN | Beta-alanine-activating enzyme | AASDH | 120 | Annotation score: | ||
E9PH98 | E9PH98_HUMAN | Beta-alanine-activating enzyme | AASDH | 86 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068620 Genomic DNA No translation available. |
RefSeqi | NP_001273598.1, NM_001286669.1 XP_016863230.1, XM_017007741.1 XP_016863231.1, XM_017007742.1 |
Genome annotation databases
Ensembli | ENST00000602986; ENSP00000473564; ENSG00000157426 |
GeneIDi | 132949 |
UCSCi | uc032tka.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068620 Genomic DNA No translation available. |
RefSeqi | NP_001273598.1, NM_001286669.1 XP_016863230.1, XM_017007741.1 XP_016863231.1, XM_017007742.1 |
3D structure databases
SMRi | R4GNB1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | R4GNB1 |
Protocols and materials databases
Antibodypediai | 24007, 57 antibodies from 16 providers |
DNASUi | 132949 |
Genome annotation databases
Ensembli | ENST00000602986; ENSP00000473564; ENSG00000157426 |
GeneIDi | 132949 |
UCSCi | uc032tka.2, human |
Organism-specific databases
CTDi | 132949 |
HGNCi | HGNC:23993, AASDH |
OpenTargetsi | ENSG00000157426 |
VEuPathDBi | HostDB:ENSG00000157426 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00440000033811 |
HOGENOMi | CLU_010423_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 132949, 2 hits in 1046 CRISPR screens |
ChiTaRSi | AASDH, human |
GenomeRNAii | 132949 |
Gene expression databases
Bgeei | ENSG00000157426, Expressed in kidney epithelium and 213 other tissues |
ExpressionAtlasi | R4GNB1, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR036736, ACP-like_sf IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR009081, PP-bd_ACP IPR025666, PQQ-like_dom IPR018391, PQQ_beta_propeller_repeat IPR002372, PQQ_repeat IPR011047, Quinoprotein_ADH-like_supfam IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF00550, PP-binding, 1 hit PF13360, PQQ_2, 1 hit PF13570, PQQ_3, 1 hit |
SMARTi | View protein in SMART SM00564, PQQ, 6 hits |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | R4GNB1_HUMAN | |
Accessioni | R4GNB1Primary (citable) accession number: R4GNB1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | October 29, 2014 | |
Last modified: | January 19, 2022 | |
This is version 66 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |