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Entry version 44 (10 Apr 2019)
Sequence version 3 (15 Feb 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

PDZD8

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transportSAAS annotation, Transport
LigandLipid-bindingSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDZD8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
R4GJL4

PRoteomics IDEntifications database

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PRIDEi
R4GJL4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000029095 Expressed in 10 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000042332

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 302SMP-LTDInterPro annotationAdd BLAST191
Domaini374 – 457PDZInterPro annotationAdd BLAST84
Domaini844 – 895Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1036 – 1071Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis, TransmembraneSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3532 Eukaryota
ENOG410ZV0K LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017746

Identification of Orthologs from Complete Genome Data

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OMAi
YLNVALW

Database of Orthologous Groups

More...
OrthoDBi
1195477at2759

Family and domain databases

Conserved Domains Database

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CDDi
cd00029 C1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR039275 PDZD8
IPR002219 PE/DAG-bd
IPR031468 SMP_LBD

The PANTHER Classification System

More...
PANTHERi
PTHR21519 PTHR21519, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF17820 PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS51847 SMP, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

R4GJL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPVYTILLS ALAGCLLTLL LQLLLLYRKA PQPPGGIGAE DGLVYARVAA
60 70 80 90 100
GRSLKDYLHG TEPVGGQAAP EPAPATATAS ASAPAASAPS AGPEPGTKPA
110 120 130 140 150
QQPEPGPEPS SSEETCHFLN AIFLFLFREL RDTALVRNWV TKKIKVEFEE
160 170 180 190 200
LLQTKMTGKV LEGLSLRDVY LGNVLPVFKA VRLIRPVVCS EEGCPEELGF
210 220 230 240 250
EVDLEYNGGF HLAIDADLVF GKSAYLFVKL SRVMGKLKLV FTRLPFTHWY
260 270 280 290 300
FSFMDDPLIV FEVKSQFEGR PMPQLTSIIV NQFKKVIKRK HTLPNYKIRY
310 320 330 340 350
KPFFPFQVSS PDEYEDRDLY IQDLPLTEGR LKVTLIECTR LFIFGSYEKE
360 370 380 390 400
TNVHCTMELS SSVWEEKSRS SIKTAELVKG NLQSVGLTLR LVQSKEDDAG
410 420 430 440 450
HVVIETVTPN SPAAAADLQR GDRLLAIGSV KITSTVQVLK LIRQAGDKVL
460 470 480 490 500
VFYERPVGYN QHGSALQDGF GQLEDTAFLT QQEDDQVSVS ADVDSRDFDS
510 520 530 540 550
EFEDLACESP DQKEDMPTTP SPKRSVVILA AKPLGTISPI LNRKLHLGNY
560 570 580 590 600
QTTSKMQQKD GAKLATPRTS DSSDTSQLSG KQSQGSGTKP PVPPRPQIRP
610 620 630 640 650
TLPTNETQNL LETGGVSSEK TEKPPPSSGN GDKCTEKVVK NNDQTEDPTL
660 670 680 690 700
SKVATIPKQD ALKDGISENA RGHKDGGDDH RTWESPEIPY RVRQGRWPKA
710 720 730 740 750
RTSSCLFEVE GSHKYLNVAL WCRDPFKAGG FICLGYASIK LEEIALDCIA
760 770 780 790 800
TSSMEYVRTF KLSAPTPKAA VTRTALRNLT THKGFNEKFC YGDIALHFKY
810 820 830 840 850
FKEGEVDDSN FLLEKEKECH LEEEVNVLQK EDTYLGQIVL TENKHNFQDT
860 870 880 890 900
QFQNPTWCDY CKKKVWTKAA SQCMLCAYVC HKKCQEKCLA ETPFCVGAEK
910 920 930 940 950
RHDRTAGGCR AEGQETSQAA SVRVDSESKS VNRTAGLTRH IINTSTRLLN
960 970 980 990 1000
LRQVPKARLS EQGTEIVEPS PKHTPNTSDN ESSDTEISGP SSPSKRASGS
1010 1020 1030 1040 1050
GIKLVRKEGG LDDSVFIAVK EIGRDLYRSL PTEERFQKLE FMLDKLQNEI
1060 1070 1080 1090 1100
DQELENNNSL VKEEKEATEA RKKALISAAL AKSGERLQAL TLLMIHYRAG
1110 1120 1130 1140 1150
IEDIESLESM SSDRQSKRVT KDSEEASIAE EVDNEDIGLT EAPTLNIISD
1160
ESVDPPQSVD
Length:1,160
Mass (Da):128,472
Last modified:February 15, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0B416C3C6366C7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AADN05000306 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_426541.2, XM_426541.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000043918; ENSGALP00000042332; ENSGALG00000029095

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
428984

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:428984

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000306 Genomic DNA No translation available.
RefSeqiXP_426541.2, XM_426541.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000042332

Proteomic databases

PaxDbiR4GJL4
PRIDEiR4GJL4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000043918; ENSGALP00000042332; ENSGALG00000029095
GeneIDi428984
KEGGigga:428984

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
118987

Phylogenomic databases

eggNOGiKOG3532 Eukaryota
ENOG410ZV0K LUCA
GeneTreeiENSGT00390000017746
OMAiYLNVALW
OrthoDBi1195477at2759

Gene expression databases

BgeeiENSGALG00000029095 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR039275 PDZD8
IPR002219 PE/DAG-bd
IPR031468 SMP_LBD
PANTHERiPTHR21519 PTHR21519, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF17820 PDZ_6, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS51847 SMP, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR4GJL4_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R4GJL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: February 15, 2017
Last modified: April 10, 2019
This is version 44 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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